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Literature summary extracted from

  • Sugimoto, S.I.; Shiho, I.
    Regulation of 6-phosphogluconate dehydrogenase in Brevibacterium flavum (1987), Agric. Biol. Chem., 51, 1257-1263.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.44 ADP
-
 [Brevibacterium] flavum
1.1.1.44 ATP
-
 [Brevibacterium] flavum
1.1.1.44 D-Fructose 1-phosphate
-
 [Brevibacterium] flavum
1.1.1.44 D-gluconate induced by Enterococcus faecalis
1.1.1.44 L-aspartate
-
 [Brevibacterium] flavum
1.1.1.44 L-histidine
-
 [Brevibacterium] flavum
1.1.1.44 L-tryptophan
-
 [Brevibacterium] flavum

General Stability

EC Number General Stability Organism
1.1.1.44 stabilized by KCl [Brevibacterium] flavum

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.44 acetyl-CoA
-
 [Brevibacterium] flavum
1.1.1.44 D-5-phosphoribosyl-1-diphosphate
-
 [Brevibacterium] flavum
1.1.1.44 D-erythrose 4-phosphate
-
 [Brevibacterium] flavum
1.1.1.44 D-fructose 1,6-diphosphate
-
 [Brevibacterium] flavum
1.1.1.44 D-fructose 1,6-diphosphate
-
 Enterococcus faecalis
1.1.1.44 D-glyceraldehyde 3-phosphate
-
 [Brevibacterium] flavum
1.1.1.44 D-ribulose 5-phosphate
-
 [Brevibacterium] flavum
1.1.1.44 D-xylulose 5-phosphate
-
 [Brevibacterium] flavum
1.1.1.44 NADPH
-
 [Brevibacterium] flavum
1.1.1.44 oxaloacetate
-
 [Brevibacterium] flavum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.44 0.036
-
 NADP+
-
 [Brevibacterium] flavum
1.1.1.44 0.045
-
 6-phosphogluconate
-
 [Brevibacterium] flavum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.44 6-phospho-D-gluconate + NADP+ Enterococcus faecalis
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ [Brevibacterium] flavum enzyme specific for the oxidative pentose phosphate pathway D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.44 Enterococcus faecalis
-
-
-
1.1.1.44 [Brevibacterium] flavum
-
 No. 2247 ATCC 14067
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.44
-
 [Brevibacterium] flavum

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.44 156
-
-
 [Brevibacterium] flavum
1.1.1.44 175
-
 cell-free extract [Brevibacterium] flavum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Enterococcus faecalis D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 [Brevibacterium] flavum D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
1.1.1.44 6-phospho-D-gluconate + NADP+ enzyme specific for the oxidative pentose phosphate pathway [Brevibacterium] flavum D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.44 7.5 8
-
 Enterococcus faecalis
1.1.1.44 7.5 8
-
 [Brevibacterium] flavum

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.44 NAD+ NAD+ specific Enterococcus faecalis
1.1.1.44 NADP+
-
 Enterococcus faecalis
1.1.1.44 NADP+ specific to NADP+ [Brevibacterium] flavum