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Literature summary extracted from

  • Seelig, G.F.; Colman, R.F.
    Characterization of the physicochemical and catalytic properties of human heart NADP-dependent isocitrate dehydrogenase (1978), Arch. Biochem. Biophys., 188, 394-409.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.42 2',5'-ADP
-
 Homo sapiens
1.1.1.42 2-oxoglutarate substrate inhibition Homo sapiens
1.1.1.42 5'-ADP
-
 Homo sapiens
1.1.1.42 ATP
-
 Homo sapiens
1.1.1.42 citrate
-
 Homo sapiens
1.1.1.42 nicotinamide mononucleotide
-
 Homo sapiens
1.1.1.42 propanetricarboxylate
-
 Homo sapiens
1.1.1.42 Threo-L-Isocitrate
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.42 0.0022
-
 D,L-isocitrate
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.42 53000
-
 gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.42 isocitrate + NADP+ Escherichia coli
-
 2-oxoglutarate + NADPH + H+ + CO2
-
 ?
1.1.1.42 isocitrate + NADP+ Homo sapiens
-
 2-oxoglutarate + NADPH + H+ + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.42 Escherichia coli
-
-
-
1.1.1.42 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.42
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.42 heart
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.42 isocitrate + NADP+
-
 Escherichia coli 2-oxoglutarate + NADPH + H+ + CO2
-
 ?
1.1.1.42 isocitrate + NADP+
-
 Homo sapiens 2-oxoglutarate + NADPH + H+ + CO2
-
 ?