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Literature summary extracted from

  • Huang, Y.C.; Kumar, A.; Colman, R.F.
    Identification of the subunits and target peptides of pig heart NAD-specific isocitrate dehydrogenase modified by the affinity label 8-(4-bromo-2,3-dioxobutylthio)NAD (1997), Arch. Biochem. Biophys., 348, 207-218.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.41 ADP
-
 Sus scrofa

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.1.41 Mg2+
-
 Sus scrofa
1.1.1.41 Mn2+
-
 Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.41 isocitrate + NAD+ Sus scrofa
-
 2-oxoglutarate + CO2 + NADH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.41 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.41 heart
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.41 8-(4-bromo-2,3-dioxobutylthio)-NAD+ + isocitrate
-
 Sus scrofa 2-oxoglutarate + CO2 + 8-(4-bromo-2,3-dioxobutylthio)-NADH
-
 ?
1.1.1.41 isocitrate + NAD+
-
 Sus scrofa 2-oxoglutarate + CO2 + NADH + H+
-
 ?

Subunits

EC Number Subunits Comment Organism
1.1.1.41 tetramer alpha2betagamma, 4 * 39000-41000, SDS-PAGE Sus scrofa

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.41 NAD+
-
 Sus scrofa