BRENDA - Enzyme Database

Kinetic regulation of yeast NAD-specific isocitrate dehydrogenase by citrate

Gabriel, J.L.; Plaut, G.W.E.; Biochemistry 30, 2594-2599 (1991)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.1.1.41
beta-mercapto-alpha-ketoglutarate
inhibition in presence and absence of AMP, competitive inhibition
Saccharomyces cerevisiae
1.1.1.41
citrate
with constant concentrations of isocitrate, NAD+ and Mg2+ up to 10 mM and without AMP, citrate is an activator
Saccharomyces cerevisiae
1.1.1.41
D,L-hibiscusate
with constant concentrations of isocitrate, NAD+ and Mg2+ up to 10 mM and without AMP, D,L-hibiscusate is an activator
Saccharomyces cerevisiae
1.1.1.41
D,L-threo-alpha-methylisocitrate
inhibition in presence and absence of AMP, competitive inhibition
Saccharomyces cerevisiae
1.1.1.41
D-malate
inhibition only in absence of AMP
Saccharomyces cerevisiae
1.1.1.41
D-Tartrate
inhibition only in absence of AMP
Saccharomyces cerevisiae
1.1.1.41
Fluorocitrate
with constant concentrations of isocitrate, NAD+ and Mg2+ up to 10 mM and without AMP, fluorocitrate is an activator
Saccharomyces cerevisiae
1.1.1.41
fumarate
inhibition only in absence of AMP
Saccharomyces cerevisiae
1.1.1.41
homocitrate
inhibition only in absence of AMP
Saccharomyces cerevisiae
1.1.1.41
L-garciniate
inhibition in presence and absence of AMP
Saccharomyces cerevisiae
1.1.1.41
L-hibiscusate
with constant concentrations of isocitrate, NAD+ and Mg2+ up to 10 mM and without AMP, L-hibiscusate is an activator
Saccharomyces cerevisiae
1.1.1.41
L-malate
inhibition only in absence of AMP, competitive inhibition
Saccharomyces cerevisiae
1.1.1.41
L-Tartrate
inhibition only in absence of AMP
Saccharomyces cerevisiae
1.1.1.41
Maleate
inhibition only in absence of AMP
Saccharomyces cerevisiae
1.1.1.41
malonate
inhibition only in absence of AMP
Saccharomyces cerevisiae
1.1.1.41
succinate
inhibition only in absence of AMP
Saccharomyces cerevisiae
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
1.1.1.41
Mg2+
-
Saccharomyces cerevisiae
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.1.1.41
isocitrate + NAD+
Saccharomyces cerevisiae
-
2-oxoglutarate + CO2 + NADH
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.1.1.41
Saccharomyces cerevisiae
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.41
isocitrate + NAD+
-
286770
Saccharomyces cerevisiae
2-oxoglutarate + CO2 + NADH
-
-
-
?
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
1.1.1.41
NAD+
-
Saccharomyces cerevisiae
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
1.1.1.41
NAD+
-
Saccharomyces cerevisiae
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.1.1.41
beta-mercapto-alpha-ketoglutarate
inhibition in presence and absence of AMP, competitive inhibition
Saccharomyces cerevisiae
1.1.1.41
citrate
with constant concentrations of isocitrate, NAD+ and Mg2+ up to 10 mM and without AMP, citrate is an activator
Saccharomyces cerevisiae
1.1.1.41
D,L-hibiscusate
with constant concentrations of isocitrate, NAD+ and Mg2+ up to 10 mM and without AMP, D,L-hibiscusate is an activator
Saccharomyces cerevisiae
1.1.1.41
D,L-threo-alpha-methylisocitrate
inhibition in presence and absence of AMP, competitive inhibition
Saccharomyces cerevisiae
1.1.1.41
D-malate
inhibition only in absence of AMP
Saccharomyces cerevisiae
1.1.1.41
D-Tartrate
inhibition only in absence of AMP
Saccharomyces cerevisiae
1.1.1.41
Fluorocitrate
with constant concentrations of isocitrate, NAD+ and Mg2+ up to 10 mM and without AMP, fluorocitrate is an activator
Saccharomyces cerevisiae
1.1.1.41
fumarate
inhibition only in absence of AMP
Saccharomyces cerevisiae
1.1.1.41
homocitrate
inhibition only in absence of AMP
Saccharomyces cerevisiae
1.1.1.41
L-garciniate
inhibition in presence and absence of AMP
Saccharomyces cerevisiae
1.1.1.41
L-hibiscusate
with constant concentrations of isocitrate, NAD+ and Mg2+ up to 10 mM and without AMP, L-hibiscusate is an activator
Saccharomyces cerevisiae
1.1.1.41
L-malate
inhibition only in absence of AMP, competitive inhibition
Saccharomyces cerevisiae
1.1.1.41
L-Tartrate
inhibition only in absence of AMP
Saccharomyces cerevisiae
1.1.1.41
Maleate
inhibition only in absence of AMP
Saccharomyces cerevisiae
1.1.1.41
malonate
inhibition only in absence of AMP
Saccharomyces cerevisiae
1.1.1.41
succinate
inhibition only in absence of AMP
Saccharomyces cerevisiae
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
1.1.1.41
Mg2+
-
Saccharomyces cerevisiae
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.1.1.41
isocitrate + NAD+
Saccharomyces cerevisiae
-
2-oxoglutarate + CO2 + NADH
-
-
?
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.41
isocitrate + NAD+
-
286770
Saccharomyces cerevisiae
2-oxoglutarate + CO2 + NADH
-
-
-
?