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Literature summary extracted from

  • Chang, G.G.; Huang, T.M.; Wang, J.K.; Lee, H.J.; Chou, W.Y.; Meng, C.L.
    Kinetic mechanism of the cytosolic malic enzyme from human breast cancer cell line (1992), Arch. Biochem. Biophys., 296, 468-473.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.40 (NH4)2SO4 at high concentrations Homo sapiens
1.1.1.40 ATP non-competitive versus L-malate Homo sapiens
1.1.1.40 NaCl at high concentrations Homo sapiens
1.1.1.40 Tartronate noncompetitive inhibitor with respect to L-malate Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.40 cytosol
-
 Homo sapiens 5829
-

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.40 Homo sapiens
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.1.1.40 (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+ sequential ordered bi-ter kinetic mechanism with NADP+ as the leading substrate followed by L-malate. The products are released in the order of CO2, pyruvate and NADPH Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.40 breast cancer cell line breast cancer cell line Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.40 (S)-malate + NADP+
-
 Homo sapiens pyruvate + CO2 + NADPH
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.1.1.40 30
-
 completely stable for at least 20 min Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.1.1.40 additional information
-
 additional information
-
 Homo sapiens