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Literature summary extracted from

  • Kiick, D.M.; Allen, B.L.; Rao, J.G.S.; Harris, B.G.; Cook, P.F.
    Determination of dissociation constants for enzyme-reactant complexes for NAD-malic enzyme by modulation of the thiol inactivation rate (1984), Biochemistry, 23, 5454-5459.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.38 4,4'-dithiodipyridine sulfhydryl reagent, rapid and complete loss of activity, presence of Mg2+ or Mn2+ enhances inactivation rate Ascaris suum
1.1.1.38 5,5'-dithiobis(2-nitrobenzoic acid) sulfhydryl reagent, rapid and complete loss of activity, presence of Mg2+ or Mn2+ enhances inactivation rate Ascaris suum
1.1.1.38 iodoacetate complete inactivation Ascaris suum
1.1.1.38 N-ethylmaleimide sulfhydryl reagent, rapid and complete loss of activity, presence of Mg2+ or Mn2+ enhances inactivation rate Ascaris suum
1.1.1.38 p-(chloromercuri)benzoate complete inactivation Ascaris suum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.38 (S)-malate + NAD+ Ascaris suum
-
 CO2 + pyruvate + NADH
-
 ?
1.1.1.38 Oxaloacetate Ascaris suum
-
 CO2 + pyruvate
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.38 Ascaris suum
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.38 (S)-malate + NAD+
-
 Ascaris suum CO2 + pyruvate + NADH
-
 ?
1.1.1.38 (S)-malate + NAD+
-
 Ascaris suum CO2 + pyruvate + NADH
-
 r
1.1.1.38 Oxaloacetate
-
 Ascaris suum CO2 + pyruvate
-
 ir

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.38 NAD+
-
 Ascaris suum