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Literature summary extracted from

  • Tyagi, A.K.; Siddiqui, F.A.; Venkitasubramanian, T.A.
    Studies on the purification and characterization of malate dehydrogenase from Mycobacterium phlei (1977), Biochim. Biophys. Acta, 485, 255-267.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.37 2-mercaptoethanol
-
Mycolicibacterium phlei
1.1.1.37 cysteine
-
Mycolicibacterium phlei
1.1.1.37 glutathione
-
Mycolicibacterium phlei

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.1.1.37
-
Mycolicibacterium phlei

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.37 Ca2+
-
Bacillus subtilis
1.1.1.37 Co2+
-
Mycolicibacterium phlei
1.1.1.37 Cu2+
-
Mycolicibacterium phlei
1.1.1.37 Hg2+
-
Mycolicibacterium phlei
1.1.1.37 iodoacetate
-
Mycolicibacterium phlei
1.1.1.37 Mg2+
-
Bacillus subtilis
1.1.1.37 Mg2+
-
Mycolicibacterium phlei
1.1.1.37 Mn2+
-
Mycolicibacterium phlei
1.1.1.37 Ni2+
-
Mycolicibacterium phlei
1.1.1.37 p-chloromercuribenzoate
-
Mycolicibacterium phlei
1.1.1.37 Zn2+
-
Bacillus subtilis
1.1.1.37 Zn2+
-
Mycolicibacterium phlei

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.37 0.027
-
NADH
-
Bacillus subtilis
1.1.1.37 0.0286
-
NADH
-
Mycolicibacterium phlei
1.1.1.37 0.0443
-
oxaloacetate
-
Mycolicibacterium phlei
1.1.1.37 0.061
-
oxaloacetate
-
Bacillus subtilis
1.1.1.37 0.14
-
NAD+
-
Bacillus subtilis
1.1.1.37 0.459
-
NAD+
-
Mycolicibacterium phlei
1.1.1.37 0.833
-
L-malate
-
Mycolicibacterium phlei
1.1.1.37 0.9
-
L-malate
-
Bacillus subtilis

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.37 21550
-
4 * 21550, SDS-PAGE Mycolicibacterium phlei
1.1.1.37 86200
-
SDS-PAGE Mycolicibacterium phlei
1.1.1.37 86860
-
gel filtration Mycolicibacterium phlei

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.37 malate + NAD+ Bacillus subtilis
-
oxaloacetate + NADH + H+
-
r
1.1.1.37 malate + NAD+ Escherichia coli
-
oxaloacetate + NADH + H+
-
r
1.1.1.37 malate + NAD+ Homo sapiens
-
oxaloacetate + NADH + H+
-
r
1.1.1.37 malate + NAD+ Bos taurus
-
oxaloacetate + NADH + H+
-
r
1.1.1.37 malate + NAD+ Neurospora crassa
-
oxaloacetate + NADH + H+
-
r
1.1.1.37 malate + NAD+ Mycolicibacterium phlei
-
oxaloacetate + NADH + H+
-
r
1.1.1.37 malate + NAD+ Mycobacterium tuberculosis
-
oxaloacetate + NADH + H+
-
r
1.1.1.37 malate + NAD+ Mycobacterium scrofulaceum
-
oxaloacetate + NADH + H+
-
r
1.1.1.37 malate + NAD+ Mycobacterium kansasii
-
oxaloacetate + NADH + H+
-
r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.37 Bacillus subtilis
-
-
-
1.1.1.37 Bos taurus
-
bovine
-
1.1.1.37 Escherichia coli
-
-
-
1.1.1.37 Homo sapiens
-
human
-
1.1.1.37 Mycobacterium kansasii
-
-
-
1.1.1.37 Mycobacterium scrofulaceum
-
-
-
1.1.1.37 Mycobacterium tuberculosis
-
H37Rv, H37Ra, BCG
-
1.1.1.37 Mycolicibacterium phlei
-
-
-
1.1.1.37 Neurospora crassa
-
-
-
1.1.1.37 no activity in Mycobacterium fortuitum
-
-
-
1.1.1.37 no activity in Mycobacterium smegmatis
-
-
-
1.1.1.37 no activity in Mycobacterium smegmatis 607
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.37
-
Mycolicibacterium phlei

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.37 erythrocyte
-
Homo sapiens
-
1.1.1.37 heart
-
Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.37 43.47
-
-
Mycolicibacterium phlei

Storage Stability

EC Number Storage Stability Organism
1.1.1.37 20°C, dilute enzyme preparation stable for at least 2 weeks Mycolicibacterium phlei
1.1.1.37 25°C, loses not more than 20% activity within 2 weeks Mycolicibacterium phlei

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.37 (S)-malate + NAD+
-
Bacillus subtilis oxaloacetate + NADH + H+
-
r
1.1.1.37 (S)-malate + NAD+
-
Escherichia coli oxaloacetate + NADH + H+
-
r
1.1.1.37 (S)-malate + NAD+
-
Homo sapiens oxaloacetate + NADH + H+
-
r
1.1.1.37 (S)-malate + NAD+
-
Bos taurus oxaloacetate + NADH + H+
-
r
1.1.1.37 (S)-malate + NAD+
-
Neurospora crassa oxaloacetate + NADH + H+
-
r
1.1.1.37 (S)-malate + NAD+
-
Mycolicibacterium phlei oxaloacetate + NADH + H+
-
r
1.1.1.37 (S)-malate + NAD+
-
Mycobacterium tuberculosis oxaloacetate + NADH + H+
-
r
1.1.1.37 (S)-malate + NAD+
-
Mycobacterium scrofulaceum oxaloacetate + NADH + H+
-
r
1.1.1.37 (S)-malate + NAD+
-
Mycobacterium kansasii oxaloacetate + NADH + H+
-
r
1.1.1.37 malate + NAD+
-
Bacillus subtilis oxaloacetate + NADH + H+
-
r
1.1.1.37 malate + NAD+
-
Escherichia coli oxaloacetate + NADH + H+
-
r
1.1.1.37 malate + NAD+
-
Homo sapiens oxaloacetate + NADH + H+
-
r
1.1.1.37 malate + NAD+
-
Bos taurus oxaloacetate + NADH + H+
-
r
1.1.1.37 malate + NAD+
-
Neurospora crassa oxaloacetate + NADH + H+
-
r
1.1.1.37 malate + NAD+
-
Mycolicibacterium phlei oxaloacetate + NADH + H+
-
r
1.1.1.37 malate + NAD+
-
Mycobacterium tuberculosis oxaloacetate + NADH + H+
-
r
1.1.1.37 malate + NAD+
-
Mycobacterium scrofulaceum oxaloacetate + NADH + H+
-
r
1.1.1.37 malate + NAD+
-
Mycobacterium kansasii oxaloacetate + NADH + H+
-
r
1.1.1.37 oxaloacetate + NADH
-
Bacillus subtilis L-malate + NAD+
-
r
1.1.1.37 oxaloacetate + NADH
-
Escherichia coli L-malate + NAD+
-
r
1.1.1.37 oxaloacetate + NADH
-
Homo sapiens L-malate + NAD+
-
r
1.1.1.37 oxaloacetate + NADH
-
Bos taurus L-malate + NAD+
-
r
1.1.1.37 oxaloacetate + NADH
-
Neurospora crassa L-malate + NAD+
-
r
1.1.1.37 oxaloacetate + NADH
-
Mycolicibacterium phlei L-malate + NAD+
-
r
1.1.1.37 oxaloacetate + NADH
-
Mycobacterium tuberculosis L-malate + NAD+
-
r
1.1.1.37 oxaloacetate + NADH
-
Mycobacterium scrofulaceum L-malate + NAD+
-
r
1.1.1.37 oxaloacetate + NADH
-
Mycobacterium kansasii L-malate + NAD+
-
r

Subunits

EC Number Subunits Comment Organism
1.1.1.37 tetramer
-
Bacillus subtilis
1.1.1.37 tetramer
-
Escherichia coli
1.1.1.37 tetramer 4 * 21550, SDS-PAGE Mycolicibacterium phlei

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.1.1.37 50
-
-
Bacillus subtilis
1.1.1.37 50
-
-
Escherichia coli
1.1.1.37 50
-
thermostable up to for 15 min Mycolicibacterium phlei

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.37 9
-
maximum conversion of malate to oxalacetate Mycolicibacterium phlei
1.1.1.37 9.2 9.6 reduction of oxalacetate to malate Mycolicibacterium phlei
1.1.1.37 9.5
-
-
Mycolicibacterium phlei

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.1.1.37 4 10
-
Mycolicibacterium phlei