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Literature summary extracted from

  • Dodds, P.F.; Guzman, M.G.F.; Chalberg, S.C.; Anderson, G.J.; Kumar, S.
    Acetoacetyl-CoA reductase activity of lactating bovine mammary fatty acid synthase (1981), J. Biol. Chem., 256, 6282-6290.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.36 CoA stimulating Rattus norvegicus
1.1.1.36 CoA stimulating Bos taurus
1.1.1.36 pantetheine stimulating Rattus norvegicus
1.1.1.36 pantetheine stimulating Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.36 2-methylcrotonyl-CoA
-
 Anser sp.
1.1.1.36 2-methylcrotonyl-CoA
-
 Bos taurus
1.1.1.36 2-methylcrotonyl-CoA
-
 Gallus gallus
1.1.1.36 2-methylcrotonyl-CoA
-
 Pigeon
1.1.1.36 2-methylcrotonyl-CoA
-
 Rattus norvegicus
1.1.1.36 2-methylcrotonyl-CoA
-
 Saccharomyces cerevisiae
1.1.1.36 acetyl-CoA
-
 Anser sp.
1.1.1.36 acetyl-CoA
-
 Bos taurus
1.1.1.36 acetyl-CoA
-
 Gallus gallus
1.1.1.36 acetyl-CoA
-
 Pigeon
1.1.1.36 acetyl-CoA
-
 Rattus norvegicus
1.1.1.36 acetyl-CoA
-
 Saccharomyces cerevisiae
1.1.1.36 butyryl-CoA
-
 Anser sp.
1.1.1.36 butyryl-CoA
-
 Bos taurus
1.1.1.36 butyryl-CoA
-
 Gallus gallus
1.1.1.36 butyryl-CoA
-
 Pigeon
1.1.1.36 butyryl-CoA
-
 Rattus norvegicus
1.1.1.36 butyryl-CoA
-
 Saccharomyces cerevisiae
1.1.1.36 iodoacetamide
-
 Anser sp.
1.1.1.36 iodoacetamide
-
 Bos taurus
1.1.1.36 iodoacetamide
-
 Gallus gallus
1.1.1.36 iodoacetamide
-
 Pigeon
1.1.1.36 iodoacetamide
-
 Rattus norvegicus
1.1.1.36 iodoacetamide
-
 Saccharomyces cerevisiae
1.1.1.36 malonyl-CoA
-
 Anser sp.
1.1.1.36 malonyl-CoA
-
 Bos taurus
1.1.1.36 malonyl-CoA
-
 Gallus gallus
1.1.1.36 malonyl-CoA
-
 Pigeon
1.1.1.36 malonyl-CoA
-
 Rattus norvegicus
1.1.1.36 malonyl-CoA
-
 Saccharomyces cerevisiae
1.1.1.36 methylmalonyl-CoA
-
 Anser sp.
1.1.1.36 methylmalonyl-CoA
-
 Bos taurus
1.1.1.36 methylmalonyl-CoA
-
 Gallus gallus
1.1.1.36 methylmalonyl-CoA
-
 Pigeon
1.1.1.36 methylmalonyl-CoA
-
 Rattus norvegicus
1.1.1.36 methylmalonyl-CoA
-
 Saccharomyces cerevisiae
1.1.1.36 N-Methylmaleimide
-
 Anser sp.
1.1.1.36 N-Methylmaleimide
-
 Bos taurus
1.1.1.36 N-Methylmaleimide
-
 Gallus gallus
1.1.1.36 N-Methylmaleimide
-
 Pigeon
1.1.1.36 N-Methylmaleimide
-
 Rattus norvegicus
1.1.1.36 N-Methylmaleimide
-
 Saccharomyces cerevisiae
1.1.1.36 N-Phenylmaleimide
-
 Anser sp.
1.1.1.36 N-Phenylmaleimide
-
 Bos taurus
1.1.1.36 N-Phenylmaleimide
-
 Gallus gallus
1.1.1.36 N-Phenylmaleimide
-
 Pigeon
1.1.1.36 N-Phenylmaleimide
-
 Rattus norvegicus
1.1.1.36 N-Phenylmaleimide
-
 Saccharomyces cerevisiae
1.1.1.36 sulfhydryl reagents
-
 Anser sp.
1.1.1.36 sulfhydryl reagents
-
 Bos taurus
1.1.1.36 sulfhydryl reagents
-
 Gallus gallus
1.1.1.36 sulfhydryl reagents
-
 Pigeon
1.1.1.36 sulfhydryl reagents
-
 Rattus norvegicus
1.1.1.36 sulfhydryl reagents
-
 Saccharomyces cerevisiae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.36 0.005
-
 acetoacetyl-CoA
-
 Rattus norvegicus
1.1.1.36 0.005
-
 acetoacetyl-CoA
-
 Bos taurus
1.1.1.36 0.04
-
 S-acetoacetyl-N-acetylcysteamine
-
 Bos taurus
1.1.1.36 0.82
-
 acetoacetyl-pantetheine
-
 Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.36 Anser sp.
-
 low activity
-
1.1.1.36 Bos taurus
-
-
-
1.1.1.36 Gallus gallus
-
 low activity
-
1.1.1.36 Pigeon
-
 low activity
-
1.1.1.36 Rattus norvegicus
-
-
-
1.1.1.36 Saccharomyces cerevisiae
-
 low activity
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.36
-
 Rattus norvegicus
1.1.1.36
-
 Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.36 adipose tissue
-
 Rattus norvegicus
-
1.1.1.36 liver
-
 Gallus gallus
-
1.1.1.36 liver
-
 Rattus norvegicus
-
1.1.1.36 liver
-
 Pigeon
-
1.1.1.36 mammary gland
-
 Rattus norvegicus
-
1.1.1.36 mammary gland
-
 Bos taurus
-
1.1.1.36 uropygial gland
-
 Anser sp.
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.36 acetoacetyl-CoA + NADPH + H+
-
 Rattus norvegicus (3R)-3-hydroxybutyryl-CoA + NADP+
-
 ir
1.1.1.36 acetoacetyl-CoA + NADPH + H+
-
 Bos taurus (3R)-3-hydroxybutyryl-CoA + NADP+
-
 ir
1.1.1.36 acetoacetyl-CoA + NADPH + H+
-
 Pigeon (3R)-3-hydroxybutyryl-CoA + NADP+
-
 ?
1.1.1.36 acetoacetyl-pantetheine + NADPH + H+
-
 Bos taurus D-3-hydroxybutyryl-pantetheine + NADP+
-
 r
1.1.1.36 S-acetoacetyl-N-acetylcysteamine + NADPH
-
 Gallus gallus 3-hydroxybutyryl-N-acetylcysteamine + NADP+
-
 ?
1.1.1.36 S-acetoacetyl-N-acetylcysteamine + NADPH
-
 Rattus norvegicus 3-hydroxybutyryl-N-acetylcysteamine + NADP+
-
 ?
1.1.1.36 S-acetoacetyl-N-acetylcysteamine + NADPH
-
 Saccharomyces cerevisiae 3-hydroxybutyryl-N-acetylcysteamine + NADP+
-
 ?
1.1.1.36 S-acetoacetyl-N-acetylcysteamine + NADPH
-
 Bos taurus 3-hydroxybutyryl-N-acetylcysteamine + NADP+
-
 ?
1.1.1.36 S-acetoacetyl-N-acetylcysteamine + NADPH
-
 Pigeon 3-hydroxybutyryl-N-acetylcysteamine + NADP+
-
 ?
1.1.1.36 S-acetoacetyl-N-acetylcysteamine + NADPH
-
 Anser sp. 3-hydroxybutyryl-N-acetylcysteamine + NADP+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.36 NADP+
-
 Gallus gallus
1.1.1.36 NADP+
-
 Rattus norvegicus
1.1.1.36 NADP+
-
 Saccharomyces cerevisiae
1.1.1.36 NADP+
-
 Bos taurus
1.1.1.36 NADP+
-
 Pigeon
1.1.1.36 NADP+
-
 Anser sp.
1.1.1.36 NADPH specific for Gallus gallus
1.1.1.36 NADPH specific for Rattus norvegicus
1.1.1.36 NADPH specific for Saccharomyces cerevisiae
1.1.1.36 NADPH specific for Bos taurus
1.1.1.36 NADPH specific for Pigeon
1.1.1.36 NADPH specific for Anser sp.