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Literature summary extracted from

  • Middleton, B.
    3-Oxoacyl-coenzyme A thiolases and L-3-hydroxyacyl-coenzyme A dehydrogenases (1978), Biochem. Soc. Trans., 6, 80-83.
    View publication on PubMed

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.35 40000
-
 liver enzyme Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.35 (S)-3-hydroxybutyryl-CoA + NAD+ Rattus norvegicus
-
 acetoacetyl-CoA + NADH
-
 r
2.3.1.16 CoA + 3-oxoacyl-CoA Escherichia coli
-
 acyl-CoA + acetyl-CoA
-
 ?
2.3.1.16 CoA + 3-oxoacyl-CoA Saccharomyces cerevisiae
-
 acyl-CoA + acetyl-CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.35 Rattus norvegicus
-
-
-
2.3.1.16 Escherichia coli
-
-
-
2.3.1.16 Saccharomyces cerevisiae
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.35 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.35 (S)-3-hydroxybutyryl-CoA + NAD+
-
 Rattus norvegicus acetoacetyl-CoA + NADH
-
 r
2.3.1.16 CoA + 3-oxoacyl-CoA
-
 Escherichia coli acyl-CoA + acetyl-CoA
-
 ?
2.3.1.16 CoA + 3-oxoacyl-CoA
-
 Saccharomyces cerevisiae acyl-CoA + acetyl-CoA
-
 ?
2.3.1.16 additional information highest activity with medium- and long-chain 3-oxoacyl-CoA substrates, but also shows significant activity with acetoacetyl-CoA (20-30% of the optimum with 3-oxohexanoyl-CoA) Escherichia coli ?
-
 ?
2.3.1.16 additional information highest activity with medium- and long-chain 3-oxoacyl-CoA substrates, but also shows significant activity with acetoacetyl-CoA (20-30% of the optimum with 3-oxohexanoyl-CoA) Saccharomyces cerevisiae ?
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.35 NAD+
-
 Rattus norvegicus