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Literature summary extracted from

  • He, X.Y.; Merz, G.; Mehta, P.; Schulz, H.; Yang, S.Y.
    Human brain short chain L-3-hydroxyacyl Coenzyme A dehydrogenase is a singl-domain multifunctional enzyme (1999), J. Biol. Chem., 274, 15014-15019.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.35 0.034
-
 (3beta,5alpha,17beta)-androstane-3,17-diol enzyme from brain Homo sapiens
1.1.1.35 0.043
-
 17beta-estradiol enzyme from brain Homo sapiens
1.1.1.35 0.045
-
 androsterone enzyme from brain Homo sapiens
1.1.1.35 0.05
-
 NAD+ enzyme from brain, substrate 17beta-estradiol Homo sapiens
1.1.1.35 0.21
-
 NAD+ enzyme from brain, substrate dihydroandrosterone Homo sapiens
1.1.1.35 0.242
-
 NAD+ enzyme from brain, substrate androsterone Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.35 endoplasmic reticulum
-
 Homo sapiens 5783
-
1.1.1.35 mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.35 (S)-3-hydroxybutyryl-CoA + NAD+ Homo sapiens
-
 acetoacetyl-CoA + NADH
-
 r
1.1.1.35 17beta-estradiol + NAD+ Homo sapiens enzyme conatains 17beta-hydroxysteroid and 3alpha-hydroxysteroid dehydrogenase activity estrone + NADH + H+
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.35 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.35 brain
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.35 0.002
-
 enzyme from brain, substrate 1-propanol Homo sapiens
1.1.1.35 0.0121
-
 enzyme from brain, substrate androsterone Homo sapiens
1.1.1.35 0.0156
-
 enzyme from brain, substrate 17beta-estradiol Homo sapiens
1.1.1.35 0.087
-
 enzyme from brain, substrate 5alpha-dihydrotestosterone Homo sapiens
1.1.1.35 0.13
-
 enzyme from brain, substrate dihydroandrosterone Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.35 (S)-3-hydroxybutyryl-CoA + NAD+
-
 Homo sapiens acetoacetyl-CoA + NADH
-
 r
1.1.1.35 1-propanol + NAD+ multifunctional enzyme from brain Homo sapiens n-propanal + NADH
-
 ir
1.1.1.35 17beta-estradiol + NAD+ enzyme from brain contains 17beta-hydroxysteroid and 3alpha-hydroxysteroid dehydrogenase activity Homo sapiens estrone + NADH + H+
-
 ir
1.1.1.35 17beta-estradiol + NAD+ enzyme conatains 17beta-hydroxysteroid and 3alpha-hydroxysteroid dehydrogenase activity Homo sapiens estrone + NADH + H+
-
 ir
1.1.1.35 2-propanol + NAD+ multifunctional enzyme from brain Homo sapiens acetone + NADH
-
 ir
1.1.1.35 5alpha-dihydrotestosterone + NADH
-
 Homo sapiens (3beta,5alpha,17beta)-androstane-3,17-diol + NAD+
-
 r
1.1.1.35 androsterone + NAD+
-
 Homo sapiens androstanedione + NADH
-
 ir

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.1.1.35 0.011
-
 androsterone enzyme from brain Homo sapiens
1.1.1.35 0.011
-
 17beta-estradiol enzyme from brain Homo sapiens
1.1.1.35 0.093
-
 (3beta,5alpha,17beta)-androstane-3,17-diol enzyme from brain Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.35 6.5 7 enzyme from brain, reduction of acetoacetyl-CoA Homo sapiens
1.1.1.35 9.5 10 enzyme from brain, oxidation of 17beta-estradiol Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.35 NAD+
-
 Homo sapiens