Literature summary extracted from

Wilding, E.I.; Kim, D.Y.; Bryant, A.P.; Gwynn, N.M.; Lunsford, R.D.; McDavitt, D.; Myers, Jr., J.E.; Rosenberg, M.; Sylvester, D.; Stauffacher, C.V.; Rodwell, V.W.
Essentiality, expression, and characterization of the class II 3-hydroxy-3-methylglutaryl coenzyme A reductase of Staphylococcus aureus (2000), J. Bacteriol., 182, 5147-5152.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
1.1.1.34	expression in Escherichia coli	Staphylococcus aureus

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.1.1.34	fluvastatin	competitive inhibitor	Staphylococcus aureus

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.1.1.34	3-hydroxy-3-methylglutaryl-CoA + NADPH	Staphylococcus aureus	-	(R)-mevalonate + CoA + NADP+	-	r

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.34	Staphylococcus aureus	-	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
1.1.1.34	-	Staphylococcus aureus

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.1.1.34	3-hydroxy-3-methylglutaryl-CoA + NADPH	-	Staphylococcus aureus	(R)-mevalonate + CoA + NADP+	-	r

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.1.1.34	NADH	-	Staphylococcus aureus
1.1.1.34	NADPH	-	Staphylococcus aureus

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Release 2023.1 (January 2023)