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Literature summary extracted from

  • Polo, M.; de Bravo, M.G.; Carbone, C.
    3-Hydroxy-3-methylglutaryl coenzyme A reductase activity in liver of athymic mice with or without an implanted human carcinoma (1999), Comp. Biochem. Physiol. B, 122, 433-437.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.34 0.01
-
 3-hydroxy-3-methylglutaryl-CoA reductase from tumor Mus musculus
1.1.1.34 0.014
-
 3-hydroxy-3-methylglutaryl-CoA reductase from liver and reductase from tumor Mus musculus
1.1.1.34 0.015
-
 3-hydroxy-3-methylglutaryl-CoA reductase from liver, implanted tumor Mus musculus
1.1.1.34 0.019
-
 3-hydroxy-3-methylglutaryl-CoA reductase from liver, implanted tumor Mus musculus
1.1.1.34 0.024
-
 3-hydroxy-3-methylglutaryl-CoA reductase from liver Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.34 microsome
-
 Mus musculus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.34 3-hydroxy-3-methylglutaryl-CoA + NADPH Mus musculus
-
 (R)-mevalonate + CoA + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.34 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.34 liver
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.34 3-hydroxy-3-methylglutaryl-CoA + NADPH
-
 Mus musculus (R)-mevalonate + CoA + NADP+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.34 NADPH
-
 Mus musculus