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Literature summary extracted from

  • Gilbert, H.F.; Stewart, M.D.
    Inactivation of hydroxymethylglutaryl-CoA reductase from yeast by coenzyme A disulfide (1981), J. Biol. Chem., 256, 1782-1785.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.34 3-hydroxy-3-methylglutaryl-CoA 0.05 mM Saccharomyces cerevisiae
1.1.1.34 CoA disulfide no inactivation in presence of NADPH 1 mM, or HMG-CoA 0.5 mM Saccharomyces cerevisiae
1.1.1.34 CoASH 0.05 mM Saccharomyces cerevisiae
1.1.1.34 DTNB
-
Saccharomyces cerevisiae
1.1.1.34 glutathione
-
Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.34 3-hydroxy-3-methylglutaryl-CoA + NADPH Saccharomyces cerevisiae
-
(R)-mevalonate + CoA + NADP+
-
?

Organic Solvent Stability

EC Number Organic Solvent Comment Organism
1.1.1.34 dithiothreitol 10 mM at pH 7 reverses CoA disulfide inactivation of enzyme Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.34 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.34 3-hydroxy-3-methylglutaryl-CoA + NADPH
-
Saccharomyces cerevisiae (R)-mevalonate + CoA + NADP+
-
?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.34 NADPH
-
Saccharomyces cerevisiae