EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.3 | additional information | cAMP-independent enzyme | Rattus norvegicus | |
2.7.11.31 | additional information | no activation by cGMP | Rattus norvegicus | |
2.7.11.31 | additional information | no activation by cAMP | Rattus norvegicus | |
2.7.11.31 | additional information | no activation by cIMP, cCMP | Rattus norvegicus | |
2.7.11.31 | Reductase kinase kinase | activation, i.e. EC 2.7.1.110, in the presence of MgATP2- | Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.3 | additional information | no inhibition by inhibitor of cAMP-dependent protein kinase | Rattus norvegicus | |
2.7.11.31 | protein phosphatase C | - |
Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.1.1.34 | microsome | - |
Rattus norvegicus | - |
- |
2.7.11.3 | cytosol | predominant | Rattus norvegicus | 5829 | - |
2.7.11.3 | additional information | subcellular distribution | Rattus norvegicus | - |
- |
2.7.11.31 | cytosol | predominant | Rattus norvegicus | 5829 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.3 | Mg2+ | requirement, actual substrate: MgATP | Rattus norvegicus | |
2.7.11.31 | Mg2+ | requirement, actual substrate: MgATP2- | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.34 | 3-hydroxy-3-methylglutaryl-CoA + NADPH | Rattus norvegicus | - |
(R)-mevalonate + CoA + NADP+ | - |
? | |
1.1.1.34 | 3-hydroxy-3-methylglutaryl-CoA + NADPH | Rattus norvegicus Wistar | - |
(R)-mevalonate + CoA + NADP+ | - |
? | |
2.7.11.3 | ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] | Rattus norvegicus | phosphorylation activates EC 2.7.1.109 | ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] | - |
? | |
2.7.11.3 | ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] | Rattus norvegicus Wistar | phosphorylation activates EC 2.7.1.109 | ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.34 | Rattus norvegicus | - |
- |
- |
2.7.11.3 | Rattus norvegicus | - |
Wistar | - |
2.7.11.3 | Rattus norvegicus Wistar | - |
Wistar | - |
2.7.11.31 | Rattus norvegicus | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
1.1.1.34 | phosphoprotein | activity is regulated by phosphorylation and dephosphorylation | Rattus norvegicus |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.1.1.34 | - |
Rattus norvegicus |
2.7.11.3 | partial | Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.1.1.34 | liver | - |
Rattus norvegicus | - |
2.7.11.3 | liver | - |
Rattus norvegicus | - |
2.7.11.31 | liver | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.34 | 3-hydroxy-3-methylglutaryl-CoA + NADPH | - |
Rattus norvegicus | (R)-mevalonate + CoA + NADP+ | - |
? | |
1.1.1.34 | 3-hydroxy-3-methylglutaryl-CoA + NADPH | - |
Rattus norvegicus Wistar | (R)-mevalonate + CoA + NADP+ | - |
? | |
2.7.11.3 | ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] | - |
Rattus norvegicus | ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] | - |
? | |
2.7.11.3 | ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] | phosphorylation activates EC 2.7.1.109 | Rattus norvegicus | ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] | - |
? | |
2.7.11.3 | ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] | - |
Rattus norvegicus Wistar | ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] | - |
? | |
2.7.11.3 | ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] | phosphorylation activates EC 2.7.1.109 | Rattus norvegicus Wistar | ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] | - |
? | |
2.7.11.31 | ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] | - |
Rattus norvegicus | ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate | - |
? | |
2.7.11.31 | ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] | - |
Rattus norvegicus Wistar | ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate | - |
? |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.7.11.31 | 37 | - |
assay at | Rattus norvegicus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.7.11.3 | 7.4 | - |
assay at | Rattus norvegicus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.34 | NADPH | - |
Rattus norvegicus |