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Literature summary extracted from

  • Ngan, H.L.; Popjak, G.
    Stereochemistry of the reaction catalyzed by mevaldate reductase (1975), Bioorg. Chem., 4, 166-180.
No PubMed abstract available

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.32 (R)-3-hydroxy-3-methyl-5-oxovaleric acid + NADH Sus scrofa
-
 (R)-3-hydroxy-3-methyl-5-hydroxyvaleric acid + NAD+
-
 ?
1.1.1.32 (S)-3-hydroxy-3-methyl-5-oxovaleric acid + NADH Sus scrofa
-
 (S)-3-hydroxy-3-methyl-5-hydroxyvaleric acid + NAD+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.32 Sus scrofa
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.1.1.32 (R)-mevalonate + NAD+ = mevaldate + NADH + H+ stereospecific insertion of hydride into C-5, hydride is added from the re-face of carbonyl group in 3R and 3S-isomers Sus scrofa
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.32 liver
-
 Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.32 0.2
-
 partially purified liver enzyme Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.32 (R)-3-hydroxy-3-methyl-5-oxovaleric acid + NADH
-
 Sus scrofa (R)-3-hydroxy-3-methyl-5-hydroxyvaleric acid + NAD+
-
 ?
1.1.1.32 (R)-3-hydroxy-3-methyl-5-oxovaleric acid + NADPH
-
 Sus scrofa (R)-3-hydroxy-3-methyl-5-hydroxyvaleric acid + NADP+
-
 ?
1.1.1.32 (S)-3-hydroxy-3-methyl-5-oxovaleric acid + NADH
-
 Sus scrofa (S)-3-hydroxy-3-methyl-5-hydroxyvaleric acid + NAD+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.32 NADH
-
 Sus scrofa