BRENDA - Enzyme Database

Inhibition of D(-)-3-hydroxybutyrate dehydrogenase by malonate analoges

Tan, A.W.H.; Smith, C.M.; Aogaichi, T.; Plaut, G.W.E.; Arch. Biochem. Biophys. 166, 164-173 (1975)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
1.1.1.30
phosphatidylcholine
-
Cavia porcellus
1.1.1.30
phosphatidylcholine
-
Rattus norvegicus
1.1.1.30
phosphatidylcholine
-
Bos taurus
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.1.1.30
bromomalonate
-
Bos taurus
1.1.1.30
bromomalonate
-
Cavia porcellus
1.1.1.30
bromomalonate
-
Rattus norvegicus
1.1.1.30
chloromalonate
-
Bos taurus
1.1.1.30
chloromalonate
-
Cavia porcellus
1.1.1.30
chloromalonate
-
Rattus norvegicus
1.1.1.30
dimethylmalonate
15.3 mM, 50% inhibition, oxidation, 11.3% reduction
Bos taurus
1.1.1.30
dimethylmalonate
7.6 mM, 50% inhibition, oxidation, 8.5 mM, reduction
Cavia porcellus
1.1.1.30
Hydroxymalonate
4.8 mM, 50% inhibition, oxidation, 7.8 reduction
Bos taurus
1.1.1.30
Hydroxymalonate
1.8 mM, 50% inhibition, oxidation, 6.0 mM, reduction
Cavia porcellus
1.1.1.30
Hydroxymalonate
-
Rattus norvegicus
1.1.1.30
malonate
9.5 mM, 50% inhibition, oxidation, 8.2 mM
Bos taurus
1.1.1.30
malonate
3.7 mM, 50% inhibition, oxidation
Cavia porcellus
1.1.1.30
malonate
-
Rattus norvegicus
1.1.1.30
mesoxalate
-
Bos taurus
1.1.1.30
mesoxalate
-
Cavia porcellus
1.1.1.30
mesoxalate
-
Rattus norvegicus
1.1.1.30
methylmalonate
2.1 mM, 50% inhibition, oxidation
Bos taurus
1.1.1.30
methylmalonate
1.4 mM, 50% inhibition, oxidation, 0.8 mM reduction
Cavia porcellus
1.1.1.30
methylmalonate
-
Rattus norvegicus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.1.1.30
(R)-3-hydroxybutanoate + NAD+
Cavia porcellus
-
acetoacetate + NADH
-
Cavia porcellus
r
1.1.1.30
(R)-3-hydroxybutanoate + NAD+
Rattus norvegicus
-
acetoacetate + NADH
-
Rattus norvegicus
r
1.1.1.30
(R)-3-hydroxybutanoate + NAD+
Bos taurus
-
acetoacetate + NADH
-
Bos taurus
r
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.1.1.30
Bos taurus
-
-
-
1.1.1.30
Cavia porcellus
-
-
-
1.1.1.30
Rattus norvegicus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.1.1.30
heart
-
Cavia porcellus
-
1.1.1.30
heart
-
Rattus norvegicus
-
1.1.1.30
heart
-
Bos taurus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.30
(R)-3-hydroxybutanoate + NAD+
-
286540
Cavia porcellus
acetoacetate + NADH
-
286540
Cavia porcellus
r
1.1.1.30
(R)-3-hydroxybutanoate + NAD+
-
286540
Rattus norvegicus
acetoacetate + NADH
-
286540
Rattus norvegicus
r
1.1.1.30
(R)-3-hydroxybutanoate + NAD+
-
286540
Bos taurus
acetoacetate + NADH
-
286540
Bos taurus
r
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
1.1.1.30
NAD+
-
Cavia porcellus
1.1.1.30
NAD+
-
Rattus norvegicus
1.1.1.30
NAD+
-
Bos taurus
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
1.1.1.30
phosphatidylcholine
-
Cavia porcellus
1.1.1.30
phosphatidylcholine
-
Rattus norvegicus
1.1.1.30
phosphatidylcholine
-
Bos taurus
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
1.1.1.30
NAD+
-
Cavia porcellus
1.1.1.30
NAD+
-
Rattus norvegicus
1.1.1.30
NAD+
-
Bos taurus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.1.1.30
bromomalonate
-
Bos taurus
1.1.1.30
bromomalonate
-
Cavia porcellus
1.1.1.30
bromomalonate
-
Rattus norvegicus
1.1.1.30
chloromalonate
-
Bos taurus
1.1.1.30
chloromalonate
-
Cavia porcellus
1.1.1.30
chloromalonate
-
Rattus norvegicus
1.1.1.30
dimethylmalonate
15.3 mM, 50% inhibition, oxidation, 11.3% reduction
Bos taurus
1.1.1.30
dimethylmalonate
7.6 mM, 50% inhibition, oxidation, 8.5 mM, reduction
Cavia porcellus
1.1.1.30
Hydroxymalonate
4.8 mM, 50% inhibition, oxidation, 7.8 reduction
Bos taurus
1.1.1.30
Hydroxymalonate
1.8 mM, 50% inhibition, oxidation, 6.0 mM, reduction
Cavia porcellus
1.1.1.30
Hydroxymalonate
-
Rattus norvegicus
1.1.1.30
malonate
9.5 mM, 50% inhibition, oxidation, 8.2 mM
Bos taurus
1.1.1.30
malonate
3.7 mM, 50% inhibition, oxidation
Cavia porcellus
1.1.1.30
malonate
-
Rattus norvegicus
1.1.1.30
mesoxalate
-
Bos taurus
1.1.1.30
mesoxalate
-
Cavia porcellus
1.1.1.30
mesoxalate
-
Rattus norvegicus
1.1.1.30
methylmalonate
2.1 mM, 50% inhibition, oxidation
Bos taurus
1.1.1.30
methylmalonate
1.4 mM, 50% inhibition, oxidation, 0.8 mM reduction
Cavia porcellus
1.1.1.30
methylmalonate
-
Rattus norvegicus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.1.1.30
(R)-3-hydroxybutanoate + NAD+
Cavia porcellus
-
acetoacetate + NADH
-
Cavia porcellus
r
1.1.1.30
(R)-3-hydroxybutanoate + NAD+
Rattus norvegicus
-
acetoacetate + NADH
-
Rattus norvegicus
r
1.1.1.30
(R)-3-hydroxybutanoate + NAD+
Bos taurus
-
acetoacetate + NADH
-
Bos taurus
r
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.1.1.30
heart
-
Cavia porcellus
-
1.1.1.30
heart
-
Rattus norvegicus
-
1.1.1.30
heart
-
Bos taurus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.30
(R)-3-hydroxybutanoate + NAD+
-
286540
Cavia porcellus
acetoacetate + NADH
-
286540
Cavia porcellus
r
1.1.1.30
(R)-3-hydroxybutanoate + NAD+
-
286540
Rattus norvegicus
acetoacetate + NADH
-
286540
Rattus norvegicus
r
1.1.1.30
(R)-3-hydroxybutanoate + NAD+
-
286540
Bos taurus
acetoacetate + NADH
-
286540
Bos taurus
r