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Literature summary extracted from

  • Dutra, J.C.; Dutra-Filho, C.S.; Cardozo, S.E.C.; Wannmacher, C.M.D.; Sarkis, J.J.F.; Wajner, M.
    Inhibition of succinate dehydrogenase and beta-hydroxybutyrate dehydrogenase activities by methylmalonate in brain and liver of developing rats (1993), J. Inherit. Metab. Dis., 16, 147-153.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.30 phosphatidylcholine
-
 Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.30 methylmalonate brain 3-hydroxybutyrate dehydrogenase, 0.5 mM 69% inhibition, 0.75 mM 83%, 1 mM 87%, 1.5 mM 3-hydroxybutyrate, liver 3-hydroxybutyrate dehydrogenase, 0.1 mM 37% inhibition, 0.25 mM 41%, 0.5 mM 45%, 1 mM 3-hydroxybutyrate, competitive inhibition Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.30 mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.30 (R)-3-hydroxybutanoate + NAD+ Rattus norvegicus
-
 acetoacetate + NADH
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.30 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.30 brain
-
 Rattus norvegicus
-
1.1.1.30 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.30 0.36
-
 liver 3-hydroxybutyrate dehydrogenase, mitochondrial extracts Rattus norvegicus
1.1.1.30 1.26
-
 brain 3-hydroxybutyrate dehydrogenase, mitochondrial extracts Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.30 (R)-3-hydroxybutanoate + NAD+
-
 Rattus norvegicus acetoacetate + NADH
-
 r

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.30 NAD+
-
 Rattus norvegicus