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Literature summary extracted from

  • Chang, G.G.; Huang, S.M.; Chiou, S.H.
    Kinetic mechanism of the endogenous lactate dehydrogenase activity of duck epsilon-crystallin (1991), Arch. Biochem. Biophys., 284, 285-291.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.27 3-Aminopyridine adenine dinucleotide competitive versus NAD+ and noncompetitive versus L-lactate Anas platyrhynchos
1.1.1.27 Alpha-NAD+ noncompetitive inhibitor versus beta-NAD+ Anas platyrhynchos
1.1.1.27 D-lactate dead-end inhibitor, competitive inhibitor versus L-lactate Anas platyrhynchos
1.1.1.27 L-lactate substrate inhibition is uncompetitive Anas platyrhynchos
1.1.1.27 nicotinic acid adenine dinucleotide competitive versus NAD+ and noncompetitive versus L-lactate Anas platyrhynchos
1.1.1.27 oxamate dead-end inhibitor, competitive inhibitor versus pyruvate Anas platyrhynchos
1.1.1.27 pyruvate substrate inhibition is uncompetitive Anas platyrhynchos
1.1.1.27 Tartronate dead-end inhibitor, competitive inhibitor versus L-lactate Anas platyrhynchos
1.1.1.27 Thionicotinamide adenine dinucleotide competitive versus NAD+ and noncompetitive versus L-lactate Anas platyrhynchos

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.27 Anas platyrhynchos
-
 epsilon-crystallin
-
1.1.1.27 Gallus gallus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.1.1.27 (S)-lactate + NAD+ = pyruvate + NADH + H+ mechanism Anas platyrhynchos
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.27 heart
-
 Gallus gallus
-
1.1.1.27 muscle
-
 Gallus gallus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.27 (S)-lactate + 3-acetylpyridine adenine dinucleotide
-
 Gallus gallus pyruvate + reduced 3-acetylpyridine adenine dinucleotide
-
 r
1.1.1.27 (S)-lactate + 3-acetylpyridine adenine dinucleotide
-
 Anas platyrhynchos pyruvate + reduced 3-acetylpyridine adenine dinucleotide
-
 r
1.1.1.27 (S)-lactate + epsilon-NAD+
-
 Anas platyrhynchos pyruvate + epsilon-NADH + H+
-
 r
1.1.1.27 (S)-lactate + nicotinamide hypoxanthine dinucleotide
-
 Gallus gallus pyruvate + reduced nicotinamide hypoxanthine dinucleotide
-
 r
1.1.1.27 (S)-lactate + nicotinamide hypoxanthine dinucleotide
-
 Anas platyrhynchos pyruvate + reduced nicotinamide hypoxanthine dinucleotide
-
 r
1.1.1.27 3-fluoropyruvate + NADH
-
 Gallus gallus ?
-
 ?
1.1.1.27 3-fluoropyruvate + NADH
-
 Anas platyrhynchos ?
-
 ?
1.1.1.27 bromopyruvate + NADH
-
 Anas platyrhynchos 3-bromo-2-hydroxypropanoate + NAD+
-
 ?
1.1.1.27 pyruvate + NADH + H+
-
 Gallus gallus (S)-lactate + NAD+
-
 ?
1.1.1.27 pyruvate + NADH + H+
-
 Anas platyrhynchos (S)-lactate + NAD+
-
 r
1.1.1.27 pyruvate ethyl ester + NADH
-
 Anas platyrhynchos 2-hydroxypropanoate ethyl ester
-
 ?
1.1.1.27 pyruvate methyl ester + NADH
-
 Anas platyrhynchos 2-hydroxypropanoate methyl ester
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.1.1.27 0.7
-
 epsilon-NAD+
-
 Anas platyrhynchos
1.1.1.27 1.1
-
 nicotinamide hypoxanthine dinucleotide
-
 Anas platyrhynchos
1.1.1.27 1.1
-
 nicotinamide hypoxanthine dinucleotide enzyme from muscle Gallus gallus
1.1.1.27 1.4
-
 3-acetylpyridine adenine dinucleotide
-
 Anas platyrhynchos
1.1.1.27 3.3
-
 NAD+ enzyme from muscle Gallus gallus
1.1.1.27 5.3
-
 epsilon-NAD+
-
 Anas platyrhynchos
1.1.1.27 5.5
-
 nicotinamide hypoxanthine dinucleotide
-
 Anas platyrhynchos
1.1.1.27 6.2
-
 epsilon-NAD+ enzyme from heart Anas platyrhynchos
1.1.1.27 6.9
-
 NAD+
-
 Anas platyrhynchos
1.1.1.27 16
-
 3-acetylpyridine adenine dinucleotide enzyme form heart and muscle Gallus gallus
1.1.1.27 18.8
-
 nicotinamide hypoxanthine dinucleotide enzyme from heart Anas platyrhynchos
1.1.1.27 60
-
 NAD+ enzyme from heart Gallus gallus
1.1.1.27 98
-
 Fluoropyruvate
-
 Gallus gallus
1.1.1.27 176
-
 pyruvate ethyl ester
-
 Anas platyrhynchos
1.1.1.27 204
-
 pyruvate
-
 Anas platyrhynchos
1.1.1.27 227
-
 pyruvate methyl ester
-
 Anas platyrhynchos
1.1.1.27 269
-
 Bromopyruvate
-
 Anas platyrhynchos

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.27 3-acetylpyridine adenine dinucleotide alternative coenzyme Anas platyrhynchos
1.1.1.27 NADH coenzyme Gallus gallus
1.1.1.27 nicotinamide hypoxanthine dinucleotide alternative coenzyme Anas platyrhynchos
1.1.1.27 thio-NAD+ alternative coenzyme Anas platyrhynchos