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Literature summary extracted from

  • Grubmeyer, C.T.; Gray, W.R.
    A cysteine residue (cysteine-116) in the histidinol binding site of histidinoldehydrogenase (1986), Biochemistry, 25, 4778-4784.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.23 7-chloro-4-nitro-2,1,3-benzoxadiazole 0.1 mM, pseudo first order inactivation, binds to Cys-116 in active site Salmonella enterica subsp. enterica serovar Typhimurium
1.1.1.23 histamine competitive inhibition Salmonella enterica subsp. enterica serovar Typhimurium
1.1.1.23 imidazole competitive inhibition Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.23 L-histidinal + NAD+ + H2O Salmonella enterica subsp. enterica serovar Typhimurium reaction intermediate L-histidine + NADH + H+
-
?
1.1.1.23 L-histidinol + 2 NAD+ + H2O Salmonella enterica subsp. enterica serovar Typhimurium
-
L-histidine + 2 NADH + 2 H+
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.23 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.23 L-histidinal + NAD+ + H2O
-
Salmonella enterica subsp. enterica serovar Typhimurium L-histidine + NADH + H+
-
?
1.1.1.23 L-histidinal + NAD+ + H2O reaction intermediate Salmonella enterica subsp. enterica serovar Typhimurium L-histidine + NADH + H+
-
?
1.1.1.23 L-histidinol + 2 NAD+ + H2O
-
Salmonella enterica subsp. enterica serovar Typhimurium L-histidine + 2 NADH + 2 H+
-
?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.23 NAD+
-
Salmonella enterica subsp. enterica serovar Typhimurium