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Literature summary extracted from

  • Sato, S.; Old, S.; Carper, D.; Kador, P.F.
    Purification and characterization of recombinant human placental and rat lens aldose reductases expressed in Escherichia coli (1995), Adv. Exp. Med. Biol., 5, 259-268.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.21 (NH4)2SO4 0.1 M Homo sapiens
1.1.1.21 (NH4)2SO4 0.1 M Rattus norvegicus
1.1.1.21 (NH4)2SO4 wild type and recombinant from Escherichia coli Homo sapiens
1.1.1.21 (NH4)2SO4 wild type and recombinant from Escherichia coli Rattus norvegicus
1.1.1.21 Na2SO4 0.1 M, wild type and recombinant from E.coli Homo sapiens
1.1.1.21 Na2SO4 0.1 M, wild type and recombinant from E.coli Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.21 expression in Escherichia coli Homo sapiens
1.1.1.21 expression in Escherichia coli Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.21 (S)-6-fluorospiro[chroman-4,5'-imidazolidine]-2',4'-dione wild type and recombinant from E. coli Homo sapiens
1.1.1.21 (S)-6-fluorospiro[chroman-4,5'-imidazolidine]-2',4'-dione wild type and recombinant from E. coli Rattus norvegicus
1.1.1.21 Cl- 0.2 M, wild type and recombinant from E. coli Homo sapiens
1.1.1.21 Cl- 0.2 M, wild type and recombinant from E. coli Rattus norvegicus
1.1.1.21 N-[[6-methoxy-5(trifluoromethyl)-1-naphthalenyl]thioxomethyl]-N-methylglycine wild type and recombinant from E. coli Homo sapiens
1.1.1.21 N-[[6-methoxy-5(trifluoromethyl)-1-naphthalenyl]thioxomethyl]-N-methylglycine wild type and recombinant from E. coli Rattus norvegicus
1.1.1.21 ponalrestat wild type and recombinant from E. coli Homo sapiens
1.1.1.21 ponalrestat wild type and recombinant from E. coli Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.21 0.046
-
 DL-glyceraldehyde
-
 Homo sapiens
1.1.1.21 0.047
-
 DL-glyceraldehyde recombinant from E. coli Homo sapiens
1.1.1.21 0.08
-
 DL-glyceraldehyde
-
 Rattus norvegicus
1.1.1.21 0.12
-
 DL-glyceraldehyde recombinant from E. coli Rattus norvegicus
1.1.1.21 4.8
-
 D-glucuronate
-
 Homo sapiens
1.1.1.21 6.4
-
 D-glucuronate recombinant from E. coli Homo sapiens
1.1.1.21 8.2
-
 D-xylose
-
 Homo sapiens
1.1.1.21 8.7
-
 D-xylose recombinant from E. coli Homo sapiens
1.1.1.21 13.5
-
 D-xylose
-
 Rattus norvegicus
1.1.1.21 13.9
-
 D-glucuronate recombinant from E. coli Rattus norvegicus
1.1.1.21 16.8
-
 D-xylose recombinant from E. coli Rattus norvegicus
1.1.1.21 19.2
-
 D-glucuronate
-
 Rattus norvegicus
1.1.1.21 42.9
-
 D-galactose recombinant from E. coli Homo sapiens
1.1.1.21 46.7
-
 D-galactose
-
 Homo sapiens
1.1.1.21 78
-
 D-galactose recombinant from E. coli Rattus norvegicus
1.1.1.21 83
-
 D-galactose
-
 Rattus norvegicus
1.1.1.21 86.8
-
 D-glucose
-
 Homo sapiens
1.1.1.21 98.1
-
 D-glucose recombinant from E. coli Homo sapiens
1.1.1.21 204
-
 D-glucose
-
 Rattus norvegicus
1.1.1.21 281
-
 D-glucose recombinant from E. coli Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.1.21 Li2SO4 0.1 M activation wild type and recombinant from E. coli Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.21 38000
-
 ? * 38000, SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.21 Homo sapiens
-
-
-
1.1.1.21 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.21 wild type and expressed in Escherichia coli Homo sapiens
1.1.1.21 wild type and expressed in Escherichia coli Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.21 lens
-
 Homo sapiens
-
1.1.1.21 lens
-
 Rattus norvegicus
-
1.1.1.21 placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.21 alditol + NAD(P)+
-
 Homo sapiens aldose + NAD(P)H
-
 r
1.1.1.21 alditol + NAD(P)+
-
 Rattus norvegicus aldose + NAD(P)H
-
 r
1.1.1.21 aldose + NAD(P)H
-
 Homo sapiens alditol + NAD(P)+
-
 r
1.1.1.21 aldose + NAD(P)H
-
 Rattus norvegicus alditol + NAD(P)+
-
 r
1.1.1.21 D-galactose + NAD(P)H
-
 Homo sapiens dulcitol + NAD(P)+
-
 r
1.1.1.21 D-galactose + NAD(P)H
-
 Rattus norvegicus dulcitol + NAD(P)+
-
 r
1.1.1.21 D-glucose + NAD(P)H
-
 Homo sapiens sorbitol + NAD(P)+
-
 r
1.1.1.21 D-glucose + NAD(P)H
-
 Rattus norvegicus sorbitol + NAD(P)+
-
 r
1.1.1.21 D-glucuronate + NAD(P)H
-
 Homo sapiens ?
-
 r
1.1.1.21 D-glucuronate + NAD(P)H
-
 Rattus norvegicus ?
-
 r
1.1.1.21 D-xylose + NAD(P)H
-
 Homo sapiens xylitol + NAD(P)+
-
 r
1.1.1.21 D-xylose + NAD(P)H
-
 Rattus norvegicus xylitol + NAD(P)+
-
 r
1.1.1.21 DL-glyceraldehyde + NAD(P)H
-
 Homo sapiens glycerol + NAD(P)+
-
 r
1.1.1.21 DL-glyceraldehyde + NAD(P)H
-
 Rattus norvegicus glycerol + NAD(P)+
-
 r

Subunits

EC Number Subunits Comment Organism
1.1.1.21 More ? * 38000, SDS-PAGE Homo sapiens