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Literature summary extracted from

  • Lau, P.C.K.; Layne, D.S.; Williamson, D.G.
    Comparison of the multiple forms of the soluble 3(17)alpha-hydroxysteroid dehydrogenases of female rabbit kidney and liver (1982), J. Biol. Chem., 257, 9450-9456.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.209 androsterone competitive vs. epitestosterone Oryctolagus cuniculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.209 0.00053
-
 Epitestosterone liver isozyme IB Oryctolagus cuniculus
1.1.1.209 0.00061
-
 Epitestosterone kidney isozyme II Oryctolagus cuniculus
1.1.1.209 0.0012
-
 androsterone liver isozyme IC Oryctolagus cuniculus
1.1.1.209 0.0021 0.0024 Epitestosterone liver isozyme IB, androsterone, kidney, isozyme IB Oryctolagus cuniculus
1.1.1.209 0.00291
-
 Epitestosterone kidney isozyme IB Oryctolagus cuniculus
1.1.1.209 0.004 0.0047 androsterone kidney isozyme II, liver isozyme IB Oryctolagus cuniculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.209 cytosol
-
 Oryctolagus cuniculus 5829
-

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.209 Oryctolagus cuniculus
-
 emale
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.209 kidney
-
 Oryctolagus cuniculus
-
1.1.1.209 liver
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.209 17alpha-estradiol + NAD(P)+
-
 Oryctolagus cuniculus estrone + NAD(P)H
-
 r
1.1.1.209 17alpha-estradiol 3-glucuronide + NAD(P)+
-
 Oryctolagus cuniculus estrone 3-glucuronide + NAD(P)H
-
 r
1.1.1.209 3alpha-hydroxy-5alpha-androstan-17-one + NAD(P)+
-
 Oryctolagus cuniculus 5alpha-androstan-3,17-dione + NAD(P)H
-
 ?
1.1.1.209 5alpha-androstan-3alpha,17beta-diol + NAD(P)+
-
 Oryctolagus cuniculus 17beta-hydroxy-5alpha-androstan-3-one + NAD(P)H i.e. 5alpha-dihydrotestosterone r
1.1.1.209 epitestosterone + NAD(P)+
-
 Oryctolagus cuniculus androst-4-en-3,17-dione + NAD(P)H + H+
-
 r
1.1.1.209 estrone 3-sulfate + NAD(P)H
-
 Oryctolagus cuniculus 17alpha-estradiol 3-sulfate + NAD(P)+
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.209 6 6.5
-
 Oryctolagus cuniculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.209 NAD+
-
 Oryctolagus cuniculus
1.1.1.209 NADH low activity Oryctolagus cuniculus
1.1.1.209 NADP+ preferred Oryctolagus cuniculus
1.1.1.209 NADPH preferred Oryctolagus cuniculus