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Literature summary extracted from

  • Arauzo, S.; Cazzulo, J.J.
    The NADP-linked aldehyde reductase from Trypanosoma cruzi subcellular localization and some properties (1989), FEMS Microbiol. Lett., 58, 283-286.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.2 iodoacetamide
-
 Trypanosoma cruzi
1.1.1.2 p-chloromercuribenzoate
-
 Trypanosoma cruzi

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.2 0.004
-
 NADPH n-propanol as substrate Trypanosoma cruzi
1.1.1.2 0.005
-
 NADPH benzaldehyde as substrate Trypanosoma cruzi
1.1.1.2 0.014
-
 NADPH propionaldehyde as substrate Trypanosoma cruzi
1.1.1.2 0.021
-
 NADPH benzyl alcohol as substrate Trypanosoma cruzi
1.1.1.2 0.22
-
 propionaldehyde
-
 Trypanosoma cruzi
1.1.1.2 0.58
-
 benzaldehyde
-
 Trypanosoma cruzi
1.1.1.2 0.8
-
 p-nitrobenzaldehyde
-
 Trypanosoma cruzi
1.1.1.2 1.43
-
 benzyl alcohol
-
 Trypanosoma cruzi
1.1.1.2 100
-
 n-Propanol
-
 Trypanosoma cruzi

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.2 cytosol
-
 Trypanosoma cruzi 5829
-

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.2 Crithidia fasciculata
-
-
-
1.1.1.2 Neurospora crassa
-
-
-
1.1.1.2 Trypanosoma cruzi
-
 Tulahuen strain, Tul 0 stock
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.2
-
 Crithidia fasciculata
1.1.1.2
-
 Trypanosoma cruzi

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.2 epimastigote
-
 Trypanosoma cruzi
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.2 2.25
-
-
 Trypanosoma cruzi

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.2 1-pentanol + NADP+
-
 Trypanosoma cruzi n-pentanal + NADPH
-
 r
1.1.1.2 acetaldehyde + NADPH + H+
-
 Trypanosoma cruzi ethanol + NADP+
-
 ?
1.1.1.2 anisaldehyde + NADPH + H+
-
 Trypanosoma cruzi anisyl alcohol + NADP+
-
 r
1.1.1.2 benzaldehyde + NADPH
-
 Trypanosoma cruzi benzyl alcohol + NADP+
-
 r
1.1.1.2 benzyl alcohol + NADP+
-
 Trypanosoma cruzi benzaldehyde + NADPH
-
 r
1.1.1.2 ethanol + NADP+
-
 Trypanosoma cruzi acetaldehyde + NADPH + H+
-
 r
1.1.1.2 additional information acetone is no substrate Trypanosoma cruzi ?
-
 ?
1.1.1.2 n-butanol + NADP+
-
 Trypanosoma cruzi butyraldehyde + NADPH
-
 r
1.1.1.2 n-propanol + NADP+
-
 Trypanosoma cruzi propionaldehyde + NADPH
-
 r
1.1.1.2 p-nitrobenzaldehyde + NADPH
-
 Trypanosoma cruzi p-nitrobenzylalcohol + NADP+
-
 ?
1.1.1.2 propionaldehyde + NADPH
-
 Trypanosoma cruzi propanol + NADP+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.2 NADP-linked aryl alcohol dehydrogenase
-
 Crithidia fasciculata

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.2 7 8 propionaldehyde as substrate Trypanosoma cruzi
1.1.1.2 9 9.5 n-propanol as substrate Trypanosoma cruzi