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Literature summary extracted from

  • Takahashi, N.; Saito, T.; Tomita, K.
    Purification and properties of an NADPH-linked aldehyde reductase from rat kidney (1983), Biochim. Biophys. Acta, 748, 444-452.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.2 Alrestatin
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.2 0.004
-
 n-octadecanal
-
 Rattus norvegicus
1.1.1.2 0.008
-
 n-hexadecanal
-
 Rattus norvegicus
1.1.1.2 0.014
-
 n-tetradecanal
-
 Rattus norvegicus
1.1.1.2 0.019
-
 n-dodecanal enzyme from brain Rattus norvegicus
1.1.1.2 0.02
-
 n-dodecanal enzyme from liver and kidney Rattus norvegicus
1.1.1.2 0.07
-
 n-decanal
-
 Rattus norvegicus
1.1.1.2 0.2
-
 p-nitrobenzaldehyde enzyme from kidney, brain or liver Rattus norvegicus
1.1.1.2 0.77
-
 n-octanal
-
 Rattus norvegicus
1.1.1.2 1.2
-
 4-Pyridinecarboxaldehyde enzyme from kidney, brain or liver Rattus norvegicus
1.1.1.2 3.3
-
 propionaldehyde
-
 Rattus norvegicus
1.1.1.2 3.8
-
 acetaldehyde
-
 Rattus norvegicus
1.1.1.2 24
-
 ethyl acetoacetate enzyme from brain or liver Rattus norvegicus
1.1.1.2 25
-
 ethyl acetoacetate enzyme from kidney Rattus norvegicus
1.1.1.2 42
-
 D-glucuronate enzyme from brain Rattus norvegicus
1.1.1.2 43
-
 D-glucuronate enzyme from kidney, or liver Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.2 cytosol
-
 Rattus norvegicus 5829
-
1.1.1.2 cytosol
-
 Bos taurus 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.2 32000
-
-
 Bos taurus
1.1.1.2 32000
-
 gel filtration Rattus norvegicus
1.1.1.2 37000
-
 1 * 37000, SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.2 ethylacetoacetate + NADPH Rattus norvegicus
-
 ethyl L-(+)-3-hydroxybutyrate + NADP+
-
 ?
1.1.1.2 succinic semialdehyde + NADPH + H+ Rattus norvegicus
-
 4-hydroxybutyrate + NADP+
-
 ?
1.1.1.2 succinic semialdehyde + NADPH + H+ Bos taurus
-
 4-hydroxybutyrate + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.2 Bos taurus
-
 bovine
-
1.1.1.2 Cavia porcellus
-
 guinea pig
-
1.1.1.2 Rattus norvegicus
-
 rat
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.2
-
 Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.2 brain
-
 Cavia porcellus
-
1.1.1.2 brain
-
 Rattus norvegicus
-
1.1.1.2 brain
-
 Bos taurus
-
1.1.1.2 heart
-
 Cavia porcellus
-
1.1.1.2 heart
-
 Rattus norvegicus
-
1.1.1.2 heart muscle Bos taurus
-
1.1.1.2 kidney
-
 Cavia porcellus
-
1.1.1.2 kidney
-
 Rattus norvegicus
-
1.1.1.2 kidney
-
 Bos taurus
-
1.1.1.2 liver
-
 Cavia porcellus
-
1.1.1.2 liver
-
 Rattus norvegicus
-
1.1.1.2 liver
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.2 5.9
-
 liver enzyme Rattus norvegicus
1.1.1.2 6
-
 brain enzyme Rattus norvegicus
1.1.1.2 11.02
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.2 4-pyridinecarboxaldehyde + NADPH
-
 Rattus norvegicus 4-pyridinemethanol + NADP+
-
 r
1.1.1.2 acetaldehyde + NADPH + H+
-
 Rattus norvegicus ethanol + NADP+
-
 ?
1.1.1.2 daunorubicin + NADPH
-
 Rattus norvegicus ? + NADP+
-
 ?
1.1.1.2 ethylacetoacetate + NADPH
-
 Rattus norvegicus ethyl L-(+)-3-hydroxybutyrate + NADP+
-
 ?
1.1.1.2 n-decanal + NADPH + H+
-
 Rattus norvegicus n-decanol + NADP+
-
 r
1.1.1.2 n-dodecanal + NADPH + H+
-
 Rattus norvegicus n-dodecanol + NADP+
-
 r
1.1.1.2 n-hexadecanal + NADPH + H+
-
 Rattus norvegicus n-hexadecanol + NADP+
-
 r
1.1.1.2 n-octadecanal + NADPH + H+
-
 Rattus norvegicus n-octadecanol + NADP+
-
 r
1.1.1.2 n-octanal + NADPH + H+
-
 Rattus norvegicus n-octanol + NADP+
-
 r
1.1.1.2 n-tetradecanal + NADPH + H+
-
 Rattus norvegicus n-tetradecanol + NADP+
-
 r
1.1.1.2 p-nitrobenzaldehyde + NADPH
-
 Rattus norvegicus p-nitrobenzylalcohol + NADP+
-
 r
1.1.1.2 p-nitrobenzaldehyde + NADPH
-
 Bos taurus p-nitrobenzylalcohol + NADP+
-
 r
1.1.1.2 propionaldehyde + NADPH
-
 Rattus norvegicus propanol + NADP+
-
 r
1.1.1.2 succinic semialdehyde + NADPH + H+
-
 Rattus norvegicus 4-hydroxybutyrate + NADP+
-
 ?
1.1.1.2 succinic semialdehyde + NADPH + H+
-
 Rattus norvegicus 4-hydroxybutyrate + NADP+
-
 r
1.1.1.2 succinic semialdehyde + NADPH + H+
-
 Bos taurus 4-hydroxybutyrate + NADP+
-
 ?
1.1.1.2 succinic semialdehyde + NADPH + H+
-
 Bos taurus 4-hydroxybutyrate + NADP+
-
 r

Subunits

EC Number Subunits Comment Organism
1.1.1.2 monomer
-
 Bos taurus
1.1.1.2 monomer 1 * 37000, SDS-PAGE Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.2 6
-
 for reduction of p-pyridinecarboxaldehyde Rattus norvegicus