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Literature summary extracted from

  • Markus, H.B.; Raducha, M.; Harris, H.
    Tissue distribution of mammalian aldose reductase and related enzymes (1983), Biochem. Med., 29, 31-45.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.2 D-glucuronate + NADPH Cavia porcellus
-
 L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH Mus musculus
-
 L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH Homo sapiens
-
 L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH Rattus norvegicus
-
 L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH Sus scrofa
-
 L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH Oryctolagus cuniculus
-
 L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH Ovis aries
-
 L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH Canis lupus familiaris
-
 L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH Felis sp.
-
 L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH Saimiri
-
 L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH Mus musculus B10.A
-
 L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH Cavia porcellus Hartley
-
 L-gulonate + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+ Cavia porcellus
-
 glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+ Mus musculus
-
 glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+ Homo sapiens
-
 glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+ Rattus norvegicus
-
 glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+ Sus scrofa
-
 glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+ Oryctolagus cuniculus
-
 glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+ Ovis aries
-
 glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+ Canis lupus familiaris
-
 glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+ Felis sp.
-
 glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+ Saimiri
-
 glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+ Mus musculus B10.A
-
 glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+ Cavia porcellus Hartley
-
 glycerol + NADP+
-
 r
1.1.1.2 L-glyceraldehyde + NADPH Cavia porcellus
-
 glycerol + NADP+
-
 r
1.1.1.2 L-glyceraldehyde + NADPH Mus musculus
-
 glycerol + NADP+
-
 r
1.1.1.2 L-glyceraldehyde + NADPH Homo sapiens
-
 glycerol + NADP+
-
 r
1.1.1.2 L-glyceraldehyde + NADPH Rattus norvegicus
-
 glycerol + NADP+
-
 r
1.1.1.2 L-glyceraldehyde + NADPH Sus scrofa
-
 glycerol + NADP+
-
 r
1.1.1.2 L-glyceraldehyde + NADPH Oryctolagus cuniculus
-
 glycerol + NADP+
-
 r
1.1.1.2 L-glyceraldehyde + NADPH Ovis aries
-
 glycerol + NADP+
-
 r
1.1.1.2 L-glyceraldehyde + NADPH Canis lupus familiaris
-
 glycerol + NADP+
-
 r
1.1.1.2 L-glyceraldehyde + NADPH Felis sp.
-
 glycerol + NADP+
-
 r
1.1.1.2 L-glyceraldehyde + NADPH Saimiri
-
 glycerol + NADP+
-
 r
1.1.1.2 L-glyceraldehyde + NADPH Mus musculus B10.A
-
 glycerol + NADP+
-
 r
1.1.1.2 L-glyceraldehyde + NADPH Cavia porcellus Hartley
-
 glycerol + NADP+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.2 Canis lupus familiaris
-
 dog, beagle, mixed breed
-
1.1.1.2 Cavia porcellus
-
 guinea pig
-
1.1.1.2 Cavia porcellus
-
 Hartley outbred.
-
1.1.1.2 Cavia porcellus Hartley
-
 Hartley outbred.
-
1.1.1.2 Felis sp.
-
 cat, mixed breed
-
1.1.1.2 Gallus sp.
-
 chicken
-
1.1.1.2 Homo sapiens
-
 human
-
1.1.1.2 Mus musculus
-
 mouse
-
1.1.1.2 Mus musculus
-
 and strains LP/J, CBAxC57, C57L/J, Nude
-
1.1.1.2 Mus musculus B10.A
-
 and strains LP/J, CBAxC57, C57L/J, Nude
-
1.1.1.2 Oryctolagus cuniculus
-
 rabbit
-
1.1.1.2 Oryctolagus cuniculus
-
 New Zealand albino, New Zealand red, Mixed breed, Chinchilla, Dutch belted
-
1.1.1.2 Ovis aries
-
 sheep
-
1.1.1.2 Ovis aries
-
 Suffolk-Hampshire
-
1.1.1.2 Rattus norvegicus
-
 rat
-
1.1.1.2 Rattus norvegicus
-
 FBNxKGH, AugxWF, BNLr-1, LEW, KGH, DA
-
1.1.1.2 Saimiri
-
-
-
1.1.1.2 Sus scrofa
-
 pig
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.2 brain
-
 Cavia porcellus
-
1.1.1.2 brain
-
 Mus musculus
-
1.1.1.2 brain
-
 Homo sapiens
-
1.1.1.2 brain
-
 Rattus norvegicus
-
1.1.1.2 brain
-
 Sus scrofa
-
1.1.1.2 brain
-
 Oryctolagus cuniculus
-
1.1.1.2 brain
-
 Ovis aries
-
1.1.1.2 brain
-
 Canis lupus familiaris
-
1.1.1.2 brain
-
 Gallus sp.
-
1.1.1.2 brain
-
 Felis sp.
-
1.1.1.2 brain
-
 Saimiri
-
1.1.1.2 heart
-
 Cavia porcellus
-
1.1.1.2 heart
-
 Mus musculus
-
1.1.1.2 heart
-
 Homo sapiens
-
1.1.1.2 heart
-
 Rattus norvegicus
-
1.1.1.2 heart
-
 Sus scrofa
-
1.1.1.2 heart
-
 Oryctolagus cuniculus
-
1.1.1.2 heart
-
 Ovis aries
-
1.1.1.2 heart
-
 Canis lupus familiaris
-
1.1.1.2 heart
-
 Gallus sp.
-
1.1.1.2 heart
-
 Felis sp.
-
1.1.1.2 heart
-
 Saimiri
-
1.1.1.2 kidney
-
 Cavia porcellus
-
1.1.1.2 kidney
-
 Mus musculus
-
1.1.1.2 kidney
-
 Homo sapiens
-
1.1.1.2 kidney
-
 Rattus norvegicus
-
1.1.1.2 kidney
-
 Sus scrofa
-
1.1.1.2 kidney
-
 Oryctolagus cuniculus
-
1.1.1.2 kidney
-
 Ovis aries
-
1.1.1.2 kidney
-
 Canis lupus familiaris
-
1.1.1.2 kidney
-
 Felis sp.
-
1.1.1.2 kidney
-
 Saimiri
-
1.1.1.2 lens
-
 Cavia porcellus
-
1.1.1.2 lens
-
 Mus musculus
-
1.1.1.2 lens
-
 Homo sapiens
-
1.1.1.2 lens
-
 Rattus norvegicus
-
1.1.1.2 lens
-
 Sus scrofa
-
1.1.1.2 lens
-
 Oryctolagus cuniculus
-
1.1.1.2 lens
-
 Ovis aries
-
1.1.1.2 lens
-
 Canis lupus familiaris
-
1.1.1.2 lens
-
 Felis sp.
-
1.1.1.2 lens
-
 Saimiri
-
1.1.1.2 liver
-
 Cavia porcellus
-
1.1.1.2 liver
-
 Mus musculus
-
1.1.1.2 liver
-
 Homo sapiens
-
1.1.1.2 liver
-
 Rattus norvegicus
-
1.1.1.2 liver
-
 Sus scrofa
-
1.1.1.2 liver
-
 Oryctolagus cuniculus
-
1.1.1.2 liver
-
 Ovis aries
-
1.1.1.2 liver
-
 Canis lupus familiaris
-
1.1.1.2 liver
-
 Felis sp.
-
1.1.1.2 liver
-
 Saimiri
-
1.1.1.2 lung
-
 Cavia porcellus
-
1.1.1.2 lung
-
 Mus musculus
-
1.1.1.2 lung
-
 Homo sapiens
-
1.1.1.2 lung
-
 Rattus norvegicus
-
1.1.1.2 lung
-
 Sus scrofa
-
1.1.1.2 lung
-
 Oryctolagus cuniculus
-
1.1.1.2 lung
-
 Ovis aries
-
1.1.1.2 lung
-
 Canis lupus familiaris
-
1.1.1.2 lung
-
 Gallus sp.
-
1.1.1.2 lung
-
 Felis sp.
-
1.1.1.2 lung
-
 Saimiri
-
1.1.1.2 placenta
-
 Cavia porcellus
-
1.1.1.2 placenta
-
 Mus musculus
-
1.1.1.2 placenta
-
 Homo sapiens
-
1.1.1.2 placenta
-
 Rattus norvegicus
-
1.1.1.2 placenta
-
 Sus scrofa
-
1.1.1.2 placenta
-
 Oryctolagus cuniculus
-
1.1.1.2 placenta
-
 Ovis aries
-
1.1.1.2 placenta
-
 Canis lupus familiaris
-
1.1.1.2 placenta
-
 Felis sp.
-
1.1.1.2 placenta
-
 Saimiri
-
1.1.1.2 seminal vesicle
-
 Cavia porcellus
-
1.1.1.2 seminal vesicle
-
 Mus musculus
-
1.1.1.2 seminal vesicle
-
 Homo sapiens
-
1.1.1.2 seminal vesicle
-
 Rattus norvegicus
-
1.1.1.2 seminal vesicle
-
 Sus scrofa
-
1.1.1.2 seminal vesicle
-
 Oryctolagus cuniculus
-
1.1.1.2 seminal vesicle
-
 Ovis aries
-
1.1.1.2 seminal vesicle
-
 Canis lupus familiaris
-
1.1.1.2 seminal vesicle
-
 Felis sp.
-
1.1.1.2 seminal vesicle
-
 Saimiri
-
1.1.1.2 testis
-
 Cavia porcellus
-
1.1.1.2 testis
-
 Mus musculus
-
1.1.1.2 testis
-
 Homo sapiens
-
1.1.1.2 testis
-
 Rattus norvegicus
-
1.1.1.2 testis
-
 Sus scrofa
-
1.1.1.2 testis
-
 Oryctolagus cuniculus
-
1.1.1.2 testis
-
 Ovis aries
-
1.1.1.2 testis
-
 Canis lupus familiaris
-
1.1.1.2 testis
-
 Felis sp.
-
1.1.1.2 testis
-
 Saimiri
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.2 3-pyridinecarboxaldehyde + NADPH
-
 Cavia porcellus 3-pyridinemethanol + NADP+
-
 r
1.1.1.2 3-pyridinecarboxaldehyde + NADPH
-
 Homo sapiens 3-pyridinemethanol + NADP+
-
 r
1.1.1.2 3-pyridinecarboxaldehyde + NADPH
-
 Rattus norvegicus 3-pyridinemethanol + NADP+
-
 r
1.1.1.2 3-pyridinecarboxaldehyde + NADPH
-
 Sus scrofa 3-pyridinemethanol + NADP+
-
 r
1.1.1.2 3-pyridinecarboxaldehyde + NADPH
-
 Oryctolagus cuniculus 3-pyridinemethanol + NADP+
-
 r
1.1.1.2 3-pyridinecarboxaldehyde + NADPH
-
 Ovis aries 3-pyridinemethanol + NADP+
-
 r
1.1.1.2 3-pyridinecarboxaldehyde + NADPH
-
 Canis lupus familiaris 3-pyridinemethanol + NADP+
-
 r
1.1.1.2 3-pyridinecarboxaldehyde + NADPH
-
 Gallus sp. 3-pyridinemethanol + NADP+
-
 ?
1.1.1.2 3-pyridinecarboxaldehyde + NADPH
-
 Felis sp. 3-pyridinemethanol + NADP+
-
 r
1.1.1.2 3-pyridinecarboxaldehyde + NADPH
-
 Cavia porcellus Hartley 3-pyridinemethanol + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH
-
 Cavia porcellus L-gulonate + NADP+
-
 ?
1.1.1.2 D-glucuronate + NADPH
-
 Cavia porcellus L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH
-
 Mus musculus L-gulonate + NADP+
-
 ?
1.1.1.2 D-glucuronate + NADPH
-
 Mus musculus L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH
-
 Homo sapiens L-gulonate + NADP+
-
 ?
1.1.1.2 D-glucuronate + NADPH
-
 Homo sapiens L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH
-
 Rattus norvegicus L-gulonate + NADP+
-
 ?
1.1.1.2 D-glucuronate + NADPH
-
 Rattus norvegicus L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH
-
 Sus scrofa L-gulonate + NADP+
-
 ?
1.1.1.2 D-glucuronate + NADPH
-
 Sus scrofa L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH
-
 Oryctolagus cuniculus L-gulonate + NADP+
-
 ?
1.1.1.2 D-glucuronate + NADPH
-
 Oryctolagus cuniculus L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH
-
 Ovis aries L-gulonate + NADP+
-
 ?
1.1.1.2 D-glucuronate + NADPH
-
 Ovis aries L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH
-
 Canis lupus familiaris L-gulonate + NADP+
-
 ?
1.1.1.2 D-glucuronate + NADPH
-
 Canis lupus familiaris L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH
-
 Gallus sp. L-gulonate + NADP+
-
 ?
1.1.1.2 D-glucuronate + NADPH
-
 Felis sp. L-gulonate + NADP+
-
 ?
1.1.1.2 D-glucuronate + NADPH
-
 Felis sp. L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH
-
 Saimiri L-gulonate + NADP+
-
 ?
1.1.1.2 D-glucuronate + NADPH
-
 Saimiri L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH
-
 Mus musculus B10.A L-gulonate + NADP+
-
 ?
1.1.1.2 D-glucuronate + NADPH
-
 Mus musculus B10.A L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH
-
 Cavia porcellus Hartley L-gulonate + NADP+
-
 ?
1.1.1.2 D-glucuronate + NADPH
-
 Cavia porcellus Hartley L-gulonate + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+
-
 Cavia porcellus glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+
-
 Mus musculus glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+
-
 Homo sapiens glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+
-
 Rattus norvegicus glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+
-
 Sus scrofa glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+
-
 Oryctolagus cuniculus glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+
-
 Ovis aries glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+
-
 Canis lupus familiaris glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+
-
 Gallus sp. glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+
-
 Felis sp. glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+
-
 Saimiri glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+
-
 Mus musculus B10.A glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+
-
 Cavia porcellus Hartley glycerol + NADP+
-
 r
1.1.1.2 L-glyceraldehyde + NADPH
-
 Cavia porcellus glycerol + NADP+
-
 r
1.1.1.2 L-glyceraldehyde + NADPH
-
 Mus musculus glycerol + NADP+
-
 r
1.1.1.2 L-glyceraldehyde + NADPH
-
 Homo sapiens glycerol + NADP+
-
 r
1.1.1.2 L-glyceraldehyde + NADPH
-
 Rattus norvegicus glycerol + NADP+
-
 r
1.1.1.2 L-glyceraldehyde + NADPH
-
 Sus scrofa glycerol + NADP+
-
 r
1.1.1.2 L-glyceraldehyde + NADPH
-
 Oryctolagus cuniculus glycerol + NADP+
-
 r
1.1.1.2 L-glyceraldehyde + NADPH
-
 Ovis aries glycerol + NADP+
-
 r
1.1.1.2 L-glyceraldehyde + NADPH
-
 Canis lupus familiaris glycerol + NADP+
-
 r
1.1.1.2 L-glyceraldehyde + NADPH
-
 Gallus sp. glycerol + NADP+
-
 r
1.1.1.2 L-glyceraldehyde + NADPH
-
 Felis sp. glycerol + NADP+
-
 r
1.1.1.2 L-glyceraldehyde + NADPH
-
 Saimiri glycerol + NADP+
-
 r
1.1.1.2 L-glyceraldehyde + NADPH
-
 Mus musculus B10.A glycerol + NADP+
-
 r
1.1.1.2 L-glyceraldehyde + NADPH
-
 Cavia porcellus Hartley glycerol + NADP+
-
 r
1.1.1.2 p-nitrobenzaldehyde + NADPH
-
 Homo sapiens p-nitrobenzylalcohol + NADP+
-
 r
1.1.1.2 p-nitrobenzaldehyde + NADPH
-
 Rattus norvegicus p-nitrobenzylalcohol + NADP+
-
 r
1.1.1.2 p-nitrobenzaldehyde + NADPH
-
 Sus scrofa p-nitrobenzylalcohol + NADP+
-
 r
1.1.1.2 p-nitrobenzaldehyde + NADPH
-
 Oryctolagus cuniculus p-nitrobenzylalcohol + NADP+
-
 r
1.1.1.2 p-nitrobenzaldehyde + NADPH
-
 Ovis aries p-nitrobenzylalcohol + NADP+
-
 r
1.1.1.2 p-nitrobenzaldehyde + NADPH
-
 Gallus sp. p-nitrobenzylalcohol + NADP+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.2 ALDR
-
 Homo sapiens