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Literature summary extracted from

  • Flynn, T.G.
    Aldehyde reductases: Monomeric NADPH-dependent oxidoreductases with multifunctional potential (1982), Biochem. Pharmacol., 31, 2705-2712.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.1.1.2 medicine
-
 Rattus norvegicus
1.1.1.2 medicine
-
 Sus scrofa
1.1.1.2 medicine brain aldehyde reductase activity is closely associated with pharmalogical actions of drugs affecting the central nervous system, anti-convulsant drugs have inhibitory effects, more work is needed for the mechanism of action of psychoactive drugs and interactions of barbiturates with aldehyde reductase Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.2 2,3-dimethylsuccinic acid
-
 Homo sapiens
1.1.1.2 2,3-dimethylsuccinic acid
-
 Sus scrofa
1.1.1.2 Alrestatin
-
 Homo sapiens
1.1.1.2 Alrestatin AY22,284A Rattus norvegicus
1.1.1.2 benzodiazepine
-
 Homo sapiens
1.1.1.2 carbamazepine
-
 Homo sapiens
1.1.1.2 EDTA lower molecular weight form Sus scrofa
1.1.1.2 p-mercuribenzoate
-
 Homo sapiens
1.1.1.2 p-mercuribenzoate
-
 Sus scrofa
1.1.1.2 phenacemide
-
 Homo sapiens
1.1.1.2 Phenylmethylsulfonylfluoride lower molecular weight form Sus scrofa
1.1.1.2 Sodium barbitone
-
 Sus scrofa
1.1.1.2 sodium valproate
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.2 cytosol
-
 Homo sapiens 5829
-
1.1.1.2 cytosol
-
 Rattus norvegicus 5829
-
1.1.1.2 cytosol
-
 Oryctolagus cuniculus 5829
-
1.1.1.2 mitochondrion
-
 Rattus norvegicus 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.2 25000
-
 gel filtration, ultracentrifugation, specific activity corresponding to molecular weight Sus scrofa
1.1.1.2 28500
-
 gel filtration, reductase I Sus scrofa
1.1.1.2 30200
-
 ultracentrifugation Sus scrofa
1.1.1.2 33000
-
 gel filtration Rattus norvegicus
1.1.1.2 33000
-
 gel filtration Sus scrofa
1.1.1.2 35000
-
-
 Homo sapiens
1.1.1.2 35000
-
 liver enzyme, reductase II, gel filtration Sus scrofa
1.1.1.2 36000
-
 gel filtration, low-Km reductase Sus scrofa
1.1.1.2 36700
-
 1 * 36700, SDS-PAGE Sus scrofa
1.1.1.2 36900
-
 1 * 36900, SDS-PAGE Sus scrofa
1.1.1.2 38000
-
 1 * 38000, SDS-PAGE Sus scrofa
1.1.1.2 40200
-
 SDS-PAGE Sus scrofa
1.1.1.2 41700
-
 1 * 41700, SDS-PAGE Sus scrofa
1.1.1.2 43700
-
 ultracentrifugation Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.2 D-glucuronate + NADPH Cavia porcellus
-
 L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH Mus musculus
-
 L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH Homo sapiens
-
 L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH Rattus norvegicus
-
 L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH Sus scrofa
-
 L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH Oryctolagus cuniculus
-
 L-gulonate + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+ Cavia porcellus
-
 glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+ Mus musculus
-
 glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+ Homo sapiens
-
 glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+ Rattus norvegicus
-
 glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+ Sus scrofa
-
 glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+ Oryctolagus cuniculus
-
 glycerol + NADP+
-
 r
1.1.1.2 L-gulonic acid + NADP+ Rattus norvegicus
-
 D-glucuronic acid + NADPH
-
 r
1.1.1.2 L-gulonic acid + NADP+ Sus scrofa
-
 D-glucuronic acid + NADPH
-
 r
1.1.1.2 L-gulonic acid + NADP+ Oryctolagus cuniculus
-
 D-glucuronic acid + NADPH
-
 r
1.1.1.2 succinic semialdehyde + NADPH + H+ Homo sapiens
-
 4-hydroxybutyrate + NADP+
-
 r
1.1.1.2 succinic semialdehyde + NADPH + H+ Rattus norvegicus
-
 4-hydroxybutyrate + NADP+
-
 r
1.1.1.2 succinic semialdehyde + NADPH + H+ Sus scrofa
-
 4-hydroxybutyrate + NADP+
-
 r
1.1.1.2 succinic semialdehyde + NADPH + H+ Oryctolagus cuniculus
-
 4-hydroxybutyrate + NADP+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.2 Cavia porcellus
-
 guinea pig
-
1.1.1.2 Drosophila melanogaster
-
 fruit fly
-
1.1.1.2 Homo sapiens
-
 human
-
1.1.1.2 Mus musculus
-
 mouse
-
1.1.1.2 Oryctolagus cuniculus
-
 rabbit
-
1.1.1.2 Rattus norvegicus
-
 rat
-
1.1.1.2 Saccharomyces cerevisiae
-
 yeast
-
1.1.1.2 Sus scrofa
-
 pig
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.2
-
 Rattus norvegicus
1.1.1.2
-
 Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.2 brain
-
 Cavia porcellus
-
1.1.1.2 brain
-
 Mus musculus
-
1.1.1.2 brain
-
 Homo sapiens
-
1.1.1.2 brain
-
 Rattus norvegicus
-
1.1.1.2 brain
-
 Sus scrofa
-
1.1.1.2 brain
-
 Oryctolagus cuniculus
-
1.1.1.2 kidney
-
 Cavia porcellus
-
1.1.1.2 kidney
-
 Mus musculus
-
1.1.1.2 kidney
-
 Homo sapiens
-
1.1.1.2 kidney
-
 Rattus norvegicus
-
1.1.1.2 kidney
-
 Sus scrofa
-
1.1.1.2 kidney
-
 Oryctolagus cuniculus
-
1.1.1.2 liver
-
 Cavia porcellus
-
1.1.1.2 liver
-
 Mus musculus
-
1.1.1.2 liver
-
 Homo sapiens
-
1.1.1.2 liver
-
 Rattus norvegicus
-
1.1.1.2 liver
-
 Sus scrofa
-
1.1.1.2 liver
-
 Oryctolagus cuniculus
-
1.1.1.2 muscle
-
 Homo sapiens
-
1.1.1.2 muscle
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.2 3-pyridinecarboxaldehyde + NADPH
-
 Cavia porcellus 3-pyridinemethanol + NADP+
-
 r
1.1.1.2 3-pyridinecarboxaldehyde + NADPH
-
 Homo sapiens 3-pyridinemethanol + NADP+
-
 r
1.1.1.2 3-pyridinecarboxaldehyde + NADPH
-
 Rattus norvegicus 3-pyridinemethanol + NADP+
-
 r
1.1.1.2 3-pyridinecarboxaldehyde + NADPH
-
 Sus scrofa 3-pyridinemethanol + NADP+
-
 r
1.1.1.2 3-pyridinecarboxaldehyde + NADPH
-
 Oryctolagus cuniculus 3-pyridinemethanol + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH
-
 Cavia porcellus L-gulonate + NADP+
-
 ?
1.1.1.2 D-glucuronate + NADPH
-
 Cavia porcellus L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH
-
 Mus musculus L-gulonate + NADP+
-
 ?
1.1.1.2 D-glucuronate + NADPH
-
 Mus musculus L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH
-
 Homo sapiens L-gulonate + NADP+
-
 ?
1.1.1.2 D-glucuronate + NADPH
-
 Homo sapiens L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH
-
 Rattus norvegicus L-gulonate + NADP+
-
 ?
1.1.1.2 D-glucuronate + NADPH
-
 Rattus norvegicus L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH
-
 Sus scrofa L-gulonate + NADP+
-
 ?
1.1.1.2 D-glucuronate + NADPH
-
 Sus scrofa L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH
-
 Oryctolagus cuniculus L-gulonate + NADP+
-
 ?
1.1.1.2 D-glucuronate + NADPH
-
 Oryctolagus cuniculus L-gulonate + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+
-
 Cavia porcellus glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+
-
 Mus musculus glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+
-
 Homo sapiens glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+
-
 Rattus norvegicus glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+
-
 Sus scrofa glycerol + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+
-
 Oryctolagus cuniculus glycerol + NADP+
-
 r
1.1.1.2 L-gulonic acid + NADP+
-
 Rattus norvegicus D-glucuronic acid + NADPH
-
 r
1.1.1.2 L-gulonic acid + NADP+
-
 Sus scrofa D-glucuronic acid + NADPH
-
 r
1.1.1.2 L-gulonic acid + NADP+
-
 Oryctolagus cuniculus D-glucuronic acid + NADPH
-
 r
1.1.1.2 L-gulonic acid + NADPH
-
 Rattus norvegicus D-glucuronic acid + NADP+
-
 r
1.1.1.2 L-gulonic acid + NADPH
-
 Sus scrofa D-glucuronic acid + NADP+
-
 r
1.1.1.2 L-gulonic acid + NADPH
-
 Oryctolagus cuniculus D-glucuronic acid + NADP+
-
 r
1.1.1.2 p-carboxybenzaldehyde + NADPH
-
 Homo sapiens p-carboxybenzyl alcohol + NADP+
-
 r
1.1.1.2 p-carboxybenzaldehyde + NADPH
-
 Rattus norvegicus p-carboxybenzyl alcohol + NADP+
-
 r
1.1.1.2 p-carboxybenzaldehyde + NADPH
-
 Sus scrofa p-carboxybenzyl alcohol + NADP+
-
 r
1.1.1.2 p-nitrobenzaldehyde + NADPH
-
 Homo sapiens p-nitrobenzylalcohol + NADP+
-
 r
1.1.1.2 p-nitrobenzaldehyde + NADPH
-
 Rattus norvegicus p-nitrobenzylalcohol + NADP+
-
 r
1.1.1.2 p-nitrobenzaldehyde + NADPH
-
 Sus scrofa p-nitrobenzylalcohol + NADP+
-
 r
1.1.1.2 p-nitrobenzaldehyde + NADPH
-
 Oryctolagus cuniculus p-nitrobenzylalcohol + NADP+
-
 r
1.1.1.2 succinic semialdehyde + NADPH + H+
-
 Homo sapiens 4-hydroxybutyrate + NADP+
-
 r
1.1.1.2 succinic semialdehyde + NADPH + H+
-
 Rattus norvegicus 4-hydroxybutyrate + NADP+
-
 r
1.1.1.2 succinic semialdehyde + NADPH + H+
-
 Sus scrofa 4-hydroxybutyrate + NADP+
-
 r
1.1.1.2 succinic semialdehyde + NADPH + H+
-
 Oryctolagus cuniculus 4-hydroxybutyrate + NADP+
-
 r

Subunits

EC Number Subunits Comment Organism
1.1.1.2 monomer
-
 Homo sapiens
1.1.1.2 monomer
-
 Rattus norvegicus
1.1.1.2 monomer
-
 Saccharomyces cerevisiae
1.1.1.2 monomer 1 * 38000, SDS-PAGE Sus scrofa
1.1.1.2 monomer 1 * 36700, SDS-PAGE Sus scrofa
1.1.1.2 monomer 1 * 40200, SDS-PAGE Sus scrofa
1.1.1.2 monomer 1 * 36900, SDS-PAGE Sus scrofa
1.1.1.2 monomer 1 * 41700, SDS-PAGE Sus scrofa

Synonyms

EC Number Synonyms Comment Organism
1.1.1.2 daunorubicin reductase
-
 Rattus norvegicus
1.1.1.2 daunorubicin reductase
-
 Sus scrofa
1.1.1.2 L-hexonate dehydrogenase
-
 Mus musculus
1.1.1.2 L-hexonate dehydrogenase
-
 Homo sapiens