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Literature summary extracted from

  • Shinoda, M.; Mori, S.; Shintani, S.; Ishikura, S.; Hara, A.
    Inhibition of human aldehyde reductase by drugs for testing the function of liver and kidney (1999), Biol. Pharm. Bull., 22, 741-744.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.1.1.2 medicine
-
 Sus scrofa
1.1.1.2 medicine drugs for testing function of liver and kidney Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.2 2,3-dimethylsuccinic acid
-
 Homo sapiens
1.1.1.2 2,3-dimethylsuccinic acid
-
 Sus scrofa
1.1.1.2 Amaranth
-
 Homo sapiens
1.1.1.2 arachidonic acid
-
 Homo sapiens
1.1.1.2 Diphenic acid
-
 Homo sapiens
1.1.1.2 Ethacrynic acid
-
 Homo sapiens
1.1.1.2 haematin
-
 Homo sapiens
1.1.1.2 indigo carmine
-
 Homo sapiens
1.1.1.2 Indocyanine green
-
 Homo sapiens
1.1.1.2 phenolsulfophthalein
-
 Homo sapiens
1.1.1.2 Rose bengal
-
 Homo sapiens
1.1.1.2 sodium valproate
-
 Homo sapiens
1.1.1.2 Sulfobromophthalein
-
 Homo sapiens
1.1.1.19 Amaranth
-
 Homo sapiens
1.1.1.19 haematin
-
 Homo sapiens
1.1.1.19 additional information potent inhibitors, i.e. carboxylic and sulfonic acids, bind weakly to the free enzyme but strongly to the enzyme-NADP+-binary complex Homo sapiens
1.1.1.19 phenolsulfophthalein
-
 Homo sapiens
1.1.1.19 Sulfobromophthalein
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.2 D-glucuronate + NADPH Homo sapiens
-
 L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH Sus scrofa
-
 L-gulonate + NADP+
-
 r
1.1.1.19 D-glucuronate + NADPH Homo sapiens
-
 L-gulonate + NADP+
-
 r
1.1.1.19 L-gulonate + NADP+ Homo sapiens
-
 D-glucuronate + NADPH
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.2 Homo sapiens
-
 human
-
1.1.1.2 Sus scrofa
-
-
-
1.1.1.19 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.2 kidney
-
 Homo sapiens
-
1.1.1.2 kidney
-
 Sus scrofa
-
1.1.1.2 liver
-
 Homo sapiens
-
1.1.1.2 liver
-
 Sus scrofa
-
1.1.1.19 kidney
-
 Homo sapiens
-
1.1.1.19 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.2 3-deoxyglucosone + NADPH
-
 Homo sapiens ? + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH
-
 Homo sapiens L-gulonate + NADP+
-
 r
1.1.1.2 D-glucuronate + NADPH
-
 Sus scrofa L-gulonate + NADP+
-
 r
1.1.1.2 iodohexadecanal + NADPH
-
 Homo sapiens iodohexadecanol + NADP+
-
 r
1.1.1.2 methylglyoxal + NADPH
-
 Homo sapiens ? + NADP+
-
 r
1.1.1.2 methylglyoxal + NADPH
-
 Sus scrofa ? + NADP+
-
 r
1.1.1.19 D-glucuronate + NADPH
-
 Homo sapiens L-gulonate + NADP+
-
 r
1.1.1.19 L-gulonate + NADP+
-
 Homo sapiens D-glucuronate + NADPH
-
 r

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.19 NADP+
-
 Homo sapiens
1.1.1.19 NADPH
-
 Homo sapiens