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Literature summary extracted from

  • Bhatnagar, A.; Das, B.; Liu, S.Q.; Srivastava, S.K.
    Human liver aldehyde reductase: pH dependence of steady-state kinetic parameters (1991), Arch. Biochem. Biophys., 287, 329-336.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.1.1.2 medicine daunorubicin, a cancer chemotherapeutic agent can be reduced by aldehyde reductase Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.2 ATP-ribose competitive inhibition Homo sapiens
1.1.1.2 diethyldicarbonate kidney aldehyde reductase Homo sapiens
1.1.1.2 NADP+ competitive inhibition Homo sapiens
1.1.1.19 ATP-ribose competitive versus NADPH Homo sapiens
1.1.1.19 menadione competitive versus D-glucuronate Homo sapiens
1.1.1.19 pyridoxal 5'-phosphate
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.2 D-glucuronate + NADPH Homo sapiens
-
 L-gulonate + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+ Homo sapiens
-
 glycerol + NADP+
-
 r
1.1.1.2 L-glyceraldehyde + NADPH Homo sapiens
-
 glycerol + NADP+
-
 r
1.1.1.2 succinic semialdehyde + NADPH + H+ Homo sapiens
-
 4-hydroxybutyrate + NADP+
-
 r
1.1.1.19 D-glucuronate + NADPH Homo sapiens
-
 L-gulonate + NADP+
-
 r
1.1.1.19 L-gulonate + NADP+ Homo sapiens
-
 D-glucuronate + NADPH
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.2 Homo sapiens
-
 human
-
1.1.1.19 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.2 liver
-
 Homo sapiens
-
1.1.1.19 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.2 D-glucuronate + NADPH
-
 Homo sapiens L-gulonate + NADP+
-
 ?
1.1.1.2 D-glucuronate + NADPH
-
 Homo sapiens L-gulonate + NADP+
-
 r
1.1.1.2 D-glyceraldehyde + NADPH + H+
-
 Homo sapiens glycerol + NADP+
-
 r
1.1.1.2 daunorubicin + NADPH
-
 Homo sapiens ? + NADP+
-
 ?
1.1.1.2 L-glyceraldehyde + NADPH
-
 Homo sapiens glycerol + NADP+
-
 r
1.1.1.2 mevaldate + NADPH
-
 Homo sapiens ? + NADP+
-
 ?
1.1.1.2 succinic semialdehyde + NADPH + H+
-
 Homo sapiens 4-hydroxybutyrate + NADP+
-
 r
1.1.1.19 D-glucuronate + NADPH
-
 Homo sapiens L-gulonate + NADP+
-
 r
1.1.1.19 L-gulonate + NADP+
-
 Homo sapiens D-glucuronate + NADPH
-
 r

Subunits

EC Number Subunits Comment Organism
1.1.1.2 monomer
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.1.1.19 additional information
-
 additional information 0.119 per mM * s, L-gulonate, steady state kinetic Homo sapiens
1.1.1.19 additional information
-
 additional information 10.82 per mM * s, D-glucuronate, steady state kinetic Homo sapiens
1.1.1.19 additional information
-
 additional information 1124 per mM * s, NADPH, steady state kinetic Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.2 8.5
-
-
 Homo sapiens
1.1.1.19 8.5
-
 substrate L-gulonate or D-glucuronate Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.1.1.19 7 10
-
 Homo sapiens

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
1.1.1.19 5 10.5 irreversible loss of activity below pH 5.0 and above pH 11 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.2 3-acetylpyridine adenine dinucleotide phosphate
-
 Homo sapiens
1.1.1.19 NADP+
-
 Homo sapiens
1.1.1.19 NADPH
-
 Homo sapiens