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Literature summary extracted from

  • Prieto, J.G.; Sarmiento, R.M.; Burgos, J.
    Kinetics of alpha-dicarbonyls reduction by L-glycol dehydrogenase from hen muscle (1983), Arch. Biochem. Biophys., 224, 372-377.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.185 acetone pI 7.2 form Gallus gallus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.185 0.0022
-
 NADPH with 2,3-pentanedione Gallus gallus
1.1.1.185 0.0024
-
 NADPH with glyoxal Gallus gallus
1.1.1.185 0.0028
-
 NADPH with methylglyoxal Gallus gallus
1.1.1.185 0.0031
-
 NADPH with diacetyl Gallus gallus
1.1.1.185 0.035
-
 2,3-Pentanedione
-
 Gallus gallus
1.1.1.185 0.09
-
 methylglyoxal pI 7.2 form Gallus gallus
1.1.1.185 0.12
-
 diacetyl pI 7.2 form Gallus gallus
1.1.1.185 0.41
-
 Glyoxal pI 7.2 form Gallus gallus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.185 Gallus gallus
-
 hen
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.185
-
 Gallus gallus

Reaction

EC Number Reaction Comment Organism Reaction ID
1.1.1.185 an L-glycol + NAD(P)+ = a 2-hydroxycarbonyl compound + NAD(P)H + H+ glyoxal reduction by enzyme form pI 7.2 follows ordered bi-bi mechanism in which the coenzyme is the first substrate to bind to the enzyme Gallus gallus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.185 muscle
-
 Gallus gallus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.185 2,3-pentanedione + NADH
-
 Gallus gallus L-acetylethylcarbinol + NAD+
-
 ?
1.1.1.185 diacetyl + NADH
-
 Gallus gallus L-acetoin + NAD+
-
 ?
1.1.1.185 glyoxal + NADPH + H+
-
 Gallus gallus ?
-
 r
1.1.1.185 methylglyoxal + NADH
-
 Gallus gallus L-lactaldehyde
-
 ?
1.1.1.185 R1-CO-CO-R2 + NAD(P)H methylglyoxal, diacetyl, 2,3-pentanedione Gallus gallus R1-CO-CHOH-R2 + NAD(P)+
-
 ?
1.1.1.185 R1-CO-CO-R2 + NAD(P)H vicinal dicarbonyl: e.g. glyoxal Gallus gallus R1-CO-CHOH-R2 + NAD(P)+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.185 NADH
-
 Gallus gallus
1.1.1.185 NADPH
-
 Gallus gallus