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Literature summary extracted from
- A coupled assay detecting defects in fibroblasts isoleucine degradation distal to enoyl-CoA hydratase: application to 3-oxothiolase deficiency (1992), Clin. Chim. Acta, 205, 127-135.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 1.1.1.178 | medicine | used for coupled enzyme assay to detect 3-oxothiolase deficiency in L-isoleucine degrading pathway | Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.178 | 2-methyl-3-hydroxybutyryl-CoA + NAD+ | Homo sapiens | isoleucine metabolism | 2-methylacetoacetyl-CoA + NADH | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.178 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.1.1.178 | fibroblast | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.178 | 2-methyl-3-hydroxybutyryl-CoA + NAD+ | - |
Homo sapiens | 2-methylacetoacetyl-CoA + NADH | - |
? | |
| 1.1.1.178 | 2-methyl-3-hydroxybutyryl-CoA + NAD+ | isoleucine metabolism | Homo sapiens | 2-methylacetoacetyl-CoA + NADH | - |
? | |
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Release 2023.1 (January 2023)
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