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Literature summary extracted from

  • Maeda, M.; Hosomi, S.; Mizoguchi, T.; Nishihara, T.
    D-erythrulose reductase can also reduce diacetyl: further purification and characterization of D-erythrulose reductase from chicken liver (1998), J. Biochem., 123, 602-606.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.162 0.021
-
 Phenanthrenequinone
-
 Gallus gallus
1.1.1.162 0.11
-
 D-erythrulose
-
 Gallus gallus
1.1.1.162 0.19
-
 3,4-hexanedione
-
 Gallus gallus
1.1.1.162 0.24
-
 2,3-Pentanedione
-
 Gallus gallus
1.1.1.162 0.26
-
 2,3-heptanedione
-
 Gallus gallus
1.1.1.162 0.39
-
 diacetyl
-
 Gallus gallus
1.1.1.162 0.67
-
 1,2-Cyclohexanedione
-
 Gallus gallus
1.1.1.162 0.68
-
 (1S)-(+)-Camphorquinone
-
 Gallus gallus
1.1.1.162 0.72
-
 isatin
-
 Gallus gallus
1.1.1.162 1.1
-
 ethyl pyruvate
-
 Gallus gallus
1.1.1.162 1.1
-
 Methyl pyruvate
-
 Gallus gallus
1.1.1.162 13
-
 acetoin
-
 Gallus gallus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.162 diacetyl + NAD(P)H Gallus gallus reaction is also performed by acetoin:NAD+ oxidoreductase, EC 1.1.1.5 acetoin + NADP+
-
 ir
1.1.1.162 diacetyl + NAD(P)H Gallus gallus detoxification of food derived dicarbonyls acetoin + NADP+
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.162 Gallus gallus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.162
-
 Gallus gallus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.162 adrenal gland
-
 Gallus gallus
-
1.1.1.162 brain
-
 Gallus gallus
-
1.1.1.162 heart
-
 Gallus gallus
-
1.1.1.162 intestine
-
 Gallus gallus
-
1.1.1.162 kidney
-
 Gallus gallus
-
1.1.1.162 liver
-
 Gallus gallus
-
1.1.1.162 additional information minimal activity also in lens, spleen, lung and pancreas Gallus gallus
-
1.1.1.162 stomach
-
 Gallus gallus
-
1.1.1.162 testis
-
 Gallus gallus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.162 0.021
-
 acetoin Gallus gallus
1.1.1.162 64
-
 (1S)-(+)-camphorquinone Gallus gallus
1.1.1.162 77
-
 methyl pyruvate Gallus gallus
1.1.1.162 83
-
 phenanthrenequione Gallus gallus
1.1.1.162 120
-
 2,3-pentanedione Gallus gallus
1.1.1.162 120
-
 ethyl pyruvate Gallus gallus
1.1.1.162 120
-
 1,2-cyclohexanedione Gallus gallus
1.1.1.162 130
-
 diacetyl Gallus gallus
1.1.1.162 180
-
 2,3-heptanedione Gallus gallus
1.1.1.162 200
-
 3,4-hexanedione Gallus gallus
1.1.1.162 250
-
 isatin Gallus gallus
1.1.1.162 320
-
 purified enzyme, D-erythrulose Gallus gallus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.162 (1S)-(+)-camphorquinone + NADPH stereospecific Gallus gallus ?
-
 ?
1.1.1.162 1,2-cyclohexanedione + NADPH
-
 Gallus gallus ?
-
 ?
1.1.1.162 2,3-heptanedione + NADPH
-
 Gallus gallus ?
-
 ?
1.1.1.162 2,3-pentanedione + NADPH
-
 Gallus gallus ?
-
 ?
1.1.1.162 3,4-hexanedione + NADPH
-
 Gallus gallus ?
-
 ?
1.1.1.162 acetoin + NADPH + H+ only slight reversibility, low activity Gallus gallus 2,3-butanediol + NADP+
-
 r
1.1.1.162 D-erythrulose + NAD(P)H
-
 Gallus gallus D-threitol + NAD(P)+
-
 r
1.1.1.162 diacetyl + NAD(P)H utilizes mainly vicinal alpha-dicarbonyls Gallus gallus acetoin + NADP+
-
 ?
1.1.1.162 diacetyl + NAD(P)H utilizes mainly vicinal alpha-dicarbonyls Gallus gallus acetoin + NADP+
-
 ir
1.1.1.162 diacetyl + NAD(P)H reaction is also performed by acetoin:NAD+ oxidoreductase, EC 1.1.1.5 Gallus gallus acetoin + NADP+
-
 ?
1.1.1.162 diacetyl + NAD(P)H reaction is also performed by acetoin:NAD+ oxidoreductase, EC 1.1.1.5 Gallus gallus acetoin + NADP+
-
 ir
1.1.1.162 diacetyl + NAD(P)H specific for alpha-dicarbonyls Gallus gallus acetoin + NADP+
-
 ?
1.1.1.162 diacetyl + NAD(P)H specific for alpha-dicarbonyls Gallus gallus acetoin + NADP+
-
 ir
1.1.1.162 diacetyl + NAD(P)H detoxification of food derived dicarbonyls Gallus gallus acetoin + NADP+
-
 ir
1.1.1.162 ethyl pyruvate + NADPH
-
 Gallus gallus ethyllactate + NADP+
-
 ?
1.1.1.162 isatin + NADPH s-cis configuration of the neighbouring carbonyls is important for activity Gallus gallus ?
-
 ?
1.1.1.162 methyl pyruvate + NADPH
-
 Gallus gallus methyllactate + NADP+
-
 ?
1.1.1.162 Phenanthrenequinone + NADPH s-cis configuration of the neighbouring carbonyls is important for activity Gallus gallus ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.162 5.8 6 diacetyl + NADPH Gallus gallus
1.1.1.162 6 6.8 diacetyl + NADH Gallus gallus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.1.1.162 7.5 9 oxidation of acetoin to 2,3-butanediol Gallus gallus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.162 NADH
-
 Gallus gallus
1.1.1.162 NADP+
-
 Gallus gallus
1.1.1.162 NADPH
-
 Gallus gallus