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Literature summary extracted from
- 17beta-Hydroxysteroid and 20alpha-hydroxysteroid dehydrogenase activities of human placental microsomes: kinetic evidence for two enzymes differing in substrate specificity (1985), Arch. Biochem. Biophys., 239, 206-215.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.62 | additional information | activity with estradiol-17beta is not inhibited by high concentrations of C19-steroids or C21-steroids | Homo sapiens | |
| 1.1.1.149 | 5alpha-dihydrotestosterone | - |
Homo sapiens |  |
| 1.1.1.149 | 5beta-dihydrotestosterone | - |
Homo sapiens | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.62 | 0.0008 | - |
estradiol-17beta | - |
Homo sapiens | |
| 1.1.1.149 | 0.0023 | - |
20alpha-hydroxy-4-pregnen-3-one | - |
Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.1.1.62 | microsome | - |
Homo sapiens | - |
- |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.62 | Homo sapiens | - |
- |
- |
| 1.1.1.149 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.1.1.62 | A-431 cell | - |
Homo sapiens | - |
| 1.1.1.62 | breast cell line | - |
Homo sapiens | - |
| 1.1.1.62 | CAOV-3 cell | - |
Homo sapiens | - |
| 1.1.1.62 | MCF-7 cell | - |
Homo sapiens | - |
| 1.1.1.62 | MCF-7 cell | breast cancer cell line MCF-7 | Homo sapiens | - |
| 1.1.1.62 | MDA-MB-231 cell | - |
Homo sapiens | - |
| 1.1.1.62 | MDA-MB-231 cell | breast cancer cell line MDA-MB-231 | Homo sapiens | - |
| 1.1.1.62 | ovarian cancer cell | - |
Homo sapiens | - |
| 1.1.1.62 | OVCAR-3 cell | - |
Homo sapiens | - |
| 1.1.1.62 | placenta | - |
Homo sapiens | - |
| 1.1.1.62 | T47D cell | - |
Homo sapiens | - |
| 1.1.1.149 | placenta | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.62 | estradiol-17beta + NAD+ | - |
Homo sapiens | estrone + NADH | - |
? | |
| 1.1.1.62 | testosterone + NADP+ | - |
Homo sapiens | 4-androstene-3,17-dione + NADPH + H+ | - |
? | |
| 1.1.1.149 | 20alpha-dihydroprogesterone + NAD+ | - |
Homo sapiens | progesterone + NADH | - |
? | |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.62 | NAD+ | cofactor | Homo sapiens | |
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