EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.146 | glycyrrhizic acid | dose-dependent competitive inhibition, IC50: 1.994 mM | Cavia porcellus | |
1.1.1.146 | gossypol acetic acid | dose-dependent competitive inhibition, IC50: 0.297 mM, (+)-isomer more potent inhibitor than (-)-isomer, mutant hairless strain more sensitive to inhibition than haired strain due to pharmacogenetic differences between the strains | Cavia porcellus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.146 | 0.0027 | - |
11beta,21-dihydroxypregn-4-en-3,20-dione | - |
Cavia porcellus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.146 | 11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+ | Cavia porcellus | - |
21-hydroxy-pregn-4-en-3,11,20-trione + NADPH + H+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.146 | Cavia porcellus | - |
guinea pig | - |
1.1.1.146 | Cavia porcellus | - |
haired and hairless strains | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.1.1.146 | kidney | cortex | Cavia porcellus | - |
EC Number | Storage Stability | Organism |
---|---|---|
1.1.1.146 | -70°C, 0.01 M sodium phosphate, pH 7.0, 0.25 M sucrose, 6 weeks | Cavia porcellus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.146 | 11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+ | - |
Cavia porcellus | 21-hydroxy-pregn-4-en-3,11,20-trione + NADPH + H+ | - |
? |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.146 | NADP+ | - |
Cavia porcellus | |
1.1.1.146 | NADPH | - |
Cavia porcellus |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
1.1.1.146 | 0.297 | - |
dose-dependent competitive inhibition, IC50: 0.297 mM, (+)-isomer more potent inhibitor than (-)-isomer, mutant hairless strain more sensitive to inhibition than haired strain due to pharmacogenetic differences between the strains | Cavia porcellus | gossypol acetic acid | |
1.1.1.146 | 1.994 | - |
dose-dependent competitive inhibition, IC50: 1.994 mM | Cavia porcellus | glycyrrhizic acid |