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Literature summary extracted from

  • Ferrari, P.; Smith, R.E.; Funder, J.W.; Krozowski, Z.S.
    Substrate and inhibitor specificity of the clones human 11beta-hydroxysteroid dehydrogenase type 2 isoform (1996), Am. J. Physiol., 270, E900-904.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.B40 11-deoxycorticosterone
-
 Homo sapiens
1.1.1.B40 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione i.e. cortisol Homo sapiens
1.1.1.B40 11beta,21-dihydroxypregn-4-en-3,20-dione 11-beta-HSD2, 50% inhibition at 0.00001 mM Homo sapiens
1.1.1.B40 aldosterone 11-beta-HSD2, 50% inhibition at 0.000005 mM Homo sapiens
1.1.1.B40 dexamethasone
-
 Homo sapiens
1.1.1.B40 progesterone
-
 Homo sapiens
1.1.1.146 11-deoxycorticosterone
-
 Homo sapiens
1.1.1.146 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione i.e. cortisol Homo sapiens
1.1.1.146 progesterone
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.B40 11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+ Homo sapiens i.e. corticosterone, significant higher rate of conversion for 11-beta-HSD2 than for 11-beta-HSD1 21-hydroxy-pregn-4-en-3,11,20-trione + NADH
-
 ir
1.1.1.146 11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+ Homo sapiens i.e. corticosterone, significant higher rate of conversion for 11-beta-HSD2 than for 11-beta-HSD1 21-hydroxy-pregn-4-en-3,11,20-trione + NADPH
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.B40 Homo sapiens
-
 isoenzymes type 1 and type 2
-
1.1.1.146 Homo sapiens
-
 isoenzymes type 1 and type 2
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.B40 11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+ i.e. corticosterone, significant higher rate of conversion for 11-beta-HSD2 than for 11-beta-HSD1 Homo sapiens 21-hydroxy-pregn-4-en-3,11,20-trione + NADH
-
 ir
1.1.1.B40 dexamethasone + NAD+ isoform 11-beta-HSD2 shows significantly higher rate of conversion than isoform 11-betaHSD1 Homo sapiens 11-dehydromethasone + NADH
-
 ir
1.1.1.146 11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+ i.e. corticosterone, significant higher rate of conversion for 11-beta-HSD2 than for 11-beta-HSD1 Homo sapiens 21-hydroxy-pregn-4-en-3,11,20-trione + NADPH
-
 ir
1.1.1.146 dexamethasone + NADP+ isoform 11-beta-HSD2 shows significantly higher rate of conversion than isoform 11-betaHSD1 Homo sapiens 11-dehydromethasone + NADPH
-
 ir

Synonyms

EC Number Synonyms Comment Organism
1.1.1.B40 11-beta-HSD2
-
 Homo sapiens
1.1.1.146 11-beta-HSD1
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.B40 NADH
-
 Homo sapiens
1.1.1.146 NADPH
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.B40 0.0000051
-
 pH and temperature not specified in the publication Homo sapiens 11beta,21-dihydroxypregn-4-en-3,20-dione
1.1.1.B40 0.000061
-
 i.e. cortisol, pH and temperature not specified in the publication Homo sapiens 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione
1.1.1.B40 0.0089
-
 pH and temperature not specified in the publication Homo sapiens dexamethasone