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Literature summary extracted from

  • Lee, S.C.; Levine, L.
    Prostaglandin metabolism. II. Identification of two 15-hydroxyprostaglandin dehydrogenase types (1975), J. Biol. Chem., 250, 548-552.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.141 3,3',5-triiodothyronine
-
 Gallus gallus
1.1.1.141 indomethacin
-
 Canis lupus familiaris
1.1.1.141 indomethacin
-
 Gallus gallus
1.1.1.141 indomethacin
-
 Homo sapiens
1.1.1.141 indomethacin
-
 Platyrrhini
1.1.1.141 indomethacin
-
 Sus scrofa
1.1.1.141 additional information not inhibited by L-thyronine and NADH Gallus gallus
1.1.1.141 additional information
-
 Homo sapiens
1.1.1.141 additional information not inhibited by thyroid hormones and NADPH Platyrrhini
1.1.1.141 NADH
-
 Gallus gallus
1.1.1.141 NADH
-
 Homo sapiens
1.1.1.141 NADH
-
 Sus scrofa
1.1.1.141 NADPH
-
 Gallus gallus
1.1.1.141 NADPH
-
 Homo sapiens
1.1.1.141 NADPH
-
 Sus scrofa
1.1.1.141 Tetraiodothyroacetic acid
-
 Gallus gallus
1.1.1.141 thyroxine
-
 Canis lupus familiaris
1.1.1.141 thyroxine
-
 Gallus gallus
1.1.1.141 thyroxine
-
 Homo sapiens
1.1.1.141 thyroxine
-
 Platyrrhini
1.1.1.141 thyroxine
-
 Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.141 0.014
-
 prostaglandin E2
-
 Gallus gallus
1.1.1.141 0.025
-
 prostaglandin F2alpha
-
 Gallus gallus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.141 Canis lupus familiaris
-
-
-
1.1.1.141 Gallus gallus
-
-
-
1.1.1.141 Homo sapiens
-
-
-
1.1.1.141 Platyrrhini
-
-
-
1.1.1.141 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.141 partial Gallus gallus
1.1.1.141 partial Platyrrhini

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.141 brain
-
 Homo sapiens
-
1.1.1.141 brain
-
 Platyrrhini
-
1.1.1.141 erythrocyte
-
 Platyrrhini
-
1.1.1.141 heart
-
 Gallus gallus
-
1.1.1.141 heart
-
 Canis lupus familiaris
-
1.1.1.141 heart
-
 Platyrrhini
-
1.1.1.141 kidney
-
 Gallus gallus
-
1.1.1.141 kidney
-
 Homo sapiens
-
1.1.1.141 kidney
-
 Sus scrofa
-
1.1.1.141 kidney
-
 Canis lupus familiaris
-
1.1.1.141 kidney
-
 Platyrrhini
-
1.1.1.141 liver
-
 Platyrrhini
-
1.1.1.141 lung
-
 Homo sapiens
-
1.1.1.141 lung
-
 Sus scrofa
-
1.1.1.141 lung
-
 Platyrrhini
-
1.1.1.141 spleen
-
 Gallus gallus
-
1.1.1.141 spleen
-
 Homo sapiens
-
1.1.1.141 spleen
-
 Sus scrofa
-
1.1.1.141 spleen
-
 Canis lupus familiaris
-
1.1.1.141 spleen
-
 Platyrrhini
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.141 0.025
-
 enzyme from heart, substrate prostaglandin E2 Gallus gallus
1.1.1.141 0.136
-
 enzyme from brain, substrate prostaglandin E2 Platyrrhini

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.141 11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+
-
 Homo sapiens 11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH
-
 ?
1.1.1.141 11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+
-
 Sus scrofa 11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH
-
 ?
1.1.1.141 11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+
-
 Canis lupus familiaris 11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH
-
 ?
1.1.1.141 11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+ NAD+ is much more effective than NADP+ Gallus gallus 11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH
-
 ?
1.1.1.141 11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+ NADP+ is more effective than NAD+ Platyrrhini 11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH
-
 ?
1.1.1.141 prostaglandin E2 + NAD+
-
 Gallus gallus 15-oxoprostaglandin E2 + NADH + H+
-
 r
1.1.1.141 prostaglandin F2alpha + NAD+
-
 Homo sapiens 15-ketoprostaglandin F2alpha + NADH + H+
-
 ?
1.1.1.141 prostaglandin F2alpha + NAD+
-
 Sus scrofa 15-ketoprostaglandin F2alpha + NADH + H+
-
 ?
1.1.1.141 prostaglandin F2alpha + NAD+
-
 Canis lupus familiaris 15-ketoprostaglandin F2alpha + NADH + H+
-
 ?
1.1.1.141 prostaglandin F2alpha + NAD+ NAD+ is much more effective than NADP+ Gallus gallus 15-ketoprostaglandin F2alpha + NADH + H+
-
 ?
1.1.1.141 prostaglandin F2alpha + NAD+ NADP+ is more effective than NAD+ Platyrrhini 15-ketoprostaglandin F2alpha + NADH + H+
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.141 7.2 8.5
-
 Gallus gallus
1.1.1.141 7.2 8.5
-
 Platyrrhini

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.141 NAD+
-
 Homo sapiens
1.1.1.141 NAD+
-
 Sus scrofa
1.1.1.141 NAD+
-
 Canis lupus familiaris
1.1.1.141 NAD+ much more effective than NADP+ Gallus gallus
1.1.1.141 NAD+ NADP+ is more effective Platyrrhini
1.1.1.141 NADP+ more efficient than NAD+ Platyrrhini