BRENDA - Enzyme Database

Inhibition and activation studies on sheep liver sorbitol dehydrogenase

Lindstad, R.I.; Hermansen, L.F.; McKinley-McKee, J.S.; Eur. J. Biochem. 221, 847-854 (1994)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
1.1.1.14
(R)-(-)-2-octanol
at pH 9.9
Ovis aries
1.1.1.14
(S)-(+)-2-octanol
at pH 9.9
Ovis aries
1.1.1.14
1-Hexanol
-
Ovis aries
1.1.1.14
1-Octanol
-
Ovis aries
1.1.1.14
2,2,2-tribromoethanol
-
Ovis aries
1.1.1.14
2,2,2-trichloroethanol
-
Ovis aries
1.1.1.14
2,2,2-Trifluoroethanol
-
Ovis aries
1.1.1.14
2-monobromoethanol
-
Ovis aries
1.1.1.14
2-monochloroethanol
-
Ovis aries
1.1.1.14
2-monofluoroethanol
-
Ovis aries
1.1.1.14
NaBr
-
Ovis aries
1.1.1.14
NaCl
-
Ovis aries
1.1.1.14
NaI
-
Ovis aries
1.1.1.14
SDS
-
Ovis aries
1.1.1.14
sodium taurodeoxycholate
-
Ovis aries
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.1.1.14
(2S)-1-(3-thio-2-methylpropionyl)-L-proline
-
Ovis aries
1.1.1.14
1,10-phenanthroline
-
Ovis aries
1.1.1.14
1,2,3,4,5,6-cyclohexanehexolphosphoric acid
at pH 9.9
Ovis aries
1.1.1.14
1,2-dithioethane
-
Ovis aries
1.1.1.14
1,7-phenanthroline
-
Ovis aries
1.1.1.14
1-thiobutane
-
Ovis aries
1.1.1.14
1-thioglycol
-
Ovis aries
1.1.1.14
1-thiosorbitol
-
Ovis aries
1.1.1.14
2,2'-dipyridyl
-
Ovis aries
1.1.1.14
2,3-Dithiopropanol
-
Ovis aries
1.1.1.14
2-hydroxybenzoic acid
at pH 9.9
Ovis aries
1.1.1.14
2-mercaptoethanol
-
Ovis aries
1.1.1.14
2-methypropanoic acid amide
at pH 9.9
Ovis aries
1.1.1.14
2-propylpentanoic acid
at pH 9.9
Ovis aries
1.1.1.14
2-thiobutane
-
Ovis aries
1.1.1.14
3,4-dihydroxyphenyl-1-hydroxyacetic acid
at pH 7.4
Ovis aries
1.1.1.14
3,4-dihydroxyphenyl-ethanediol
at pH 7.4
Ovis aries
1.1.1.14
3-hydroxy-4-methoxy-phenyl-1-hydroxy-acetic acid
at pH 7.4
Ovis aries
1.1.1.14
4,4'-dipyridyl
-
Ovis aries
1.1.1.14
4-hydroxy-3-methoxy-phenyl-1-hydroxy-acetic acid
at pH 7.4
Ovis aries
1.1.1.14
4-hydroxy-3-methoxy-phenylacetic acid
at pH 7.4
Ovis aries
1.1.1.14
4-hydroxy-3-methoxy-phenylethanediol
at pH 7.4
Ovis aries
1.1.1.14
4-hydroxy-3-methoxy-phenylethyl alcohol
at pH 7.4
Ovis aries
1.1.1.14
8-hydroxyquinoline
-
Ovis aries
1.1.1.14
acetic acid amide
at pH 9.9
Ovis aries
1.1.1.14
Alrestatin
-
Ovis aries
1.1.1.14
Berberine
-
Ovis aries
1.1.1.14
bis-diethylthiocarbamoyldisulfide
-
Ovis aries
1.1.1.14
butanedioic acid
at pH 9.9
Ovis aries
1.1.1.14
Cibacron Blue 3G-A
-
Ovis aries
1.1.1.14
cyanamide
at pH 9.9
Ovis aries
1.1.1.14
cysteamine
significant only at pH 9.9
Ovis aries
1.1.1.14
cysteine
-
Ovis aries
1.1.1.14
Decanoic acid
at pH 9.9
Ovis aries
1.1.1.14
Diethylthiocarbamate
at pH 9.9
Ovis aries
1.1.1.14
dithiothreitol
-
Ovis aries
1.1.1.14
DL-2-thiovaline
-
Ovis aries
1.1.1.14
Eriochrome Black T
-
Ovis aries
1.1.1.14
ethanedioic acid
at pH 9.9
Ovis aries
1.1.1.14
ICI 171071
-
Ovis aries
1.1.1.14
ICI 222155
-
Ovis aries
1.1.1.14
imidazole
-
Ovis aries
1.1.1.14
Isonicotinic acid hydrazide
-
Ovis aries
1.1.1.14
ponalrestat
-
Ovis aries
1.1.1.14
propanedioic acid
at pH 9.9
Ovis aries
1.1.1.14
pyrazole
-
Ovis aries
1.1.1.14
quercetin
at pH 7.4
Ovis aries
1.1.1.14
thioacetate
at pH 9.9
Ovis aries
1.1.1.14
thiocyanate
at pH 9.9
Ovis aries
1.1.1.14
Thiourea
at pH 9.9
Ovis aries
1.1.1.14
Tolrestat
-
Ovis aries
1.1.1.14
Urea
at pH 9.9
Ovis aries
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.1.1.14
Ovis aries
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.1.1.14
liver
-
Ovis aries
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.14
D-sorbitol + NAD+
-
285889
Ovis aries
D-fructose + NADH + H+
-
-
-
-
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
1.1.1.14
NAD+
-
Ovis aries
1.1.1.14
NADH
-
Ovis aries
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
1.1.1.14
(R)-(-)-2-octanol
at pH 9.9
Ovis aries
1.1.1.14
(S)-(+)-2-octanol
at pH 9.9
Ovis aries
1.1.1.14
1-Hexanol
-
Ovis aries
1.1.1.14
1-Octanol
-
Ovis aries
1.1.1.14
2,2,2-tribromoethanol
-
Ovis aries
1.1.1.14
2,2,2-trichloroethanol
-
Ovis aries
1.1.1.14
2,2,2-Trifluoroethanol
-
Ovis aries
1.1.1.14
2-monobromoethanol
-
Ovis aries
1.1.1.14
2-monochloroethanol
-
Ovis aries
1.1.1.14
2-monofluoroethanol
-
Ovis aries
1.1.1.14
NaBr
-
Ovis aries
1.1.1.14
NaCl
-
Ovis aries
1.1.1.14
NaI
-
Ovis aries
1.1.1.14
SDS
-
Ovis aries
1.1.1.14
sodium taurodeoxycholate
-
Ovis aries
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
1.1.1.14
NAD+
-
Ovis aries
1.1.1.14
NADH
-
Ovis aries
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.1.1.14
(2S)-1-(3-thio-2-methylpropionyl)-L-proline
-
Ovis aries
1.1.1.14
1,10-phenanthroline
-
Ovis aries
1.1.1.14
1,2,3,4,5,6-cyclohexanehexolphosphoric acid
at pH 9.9
Ovis aries
1.1.1.14
1,2-dithioethane
-
Ovis aries
1.1.1.14
1,7-phenanthroline
-
Ovis aries
1.1.1.14
1-thiobutane
-
Ovis aries
1.1.1.14
1-thioglycol
-
Ovis aries
1.1.1.14
1-thiosorbitol
-
Ovis aries
1.1.1.14
2,2'-dipyridyl
-
Ovis aries
1.1.1.14
2,3-Dithiopropanol
-
Ovis aries
1.1.1.14
2-hydroxybenzoic acid
at pH 9.9
Ovis aries
1.1.1.14
2-mercaptoethanol
-
Ovis aries
1.1.1.14
2-methypropanoic acid amide
at pH 9.9
Ovis aries
1.1.1.14
2-propylpentanoic acid
at pH 9.9
Ovis aries
1.1.1.14
2-thiobutane
-
Ovis aries
1.1.1.14
3,4-dihydroxyphenyl-1-hydroxyacetic acid
at pH 7.4
Ovis aries
1.1.1.14
3,4-dihydroxyphenyl-ethanediol
at pH 7.4
Ovis aries
1.1.1.14
3-hydroxy-4-methoxy-phenyl-1-hydroxy-acetic acid
at pH 7.4
Ovis aries
1.1.1.14
4,4'-dipyridyl
-
Ovis aries
1.1.1.14
4-hydroxy-3-methoxy-phenyl-1-hydroxy-acetic acid
at pH 7.4
Ovis aries
1.1.1.14
4-hydroxy-3-methoxy-phenylacetic acid
at pH 7.4
Ovis aries
1.1.1.14
4-hydroxy-3-methoxy-phenylethanediol
at pH 7.4
Ovis aries
1.1.1.14
4-hydroxy-3-methoxy-phenylethyl alcohol
at pH 7.4
Ovis aries
1.1.1.14
8-hydroxyquinoline
-
Ovis aries
1.1.1.14
acetic acid amide
at pH 9.9
Ovis aries
1.1.1.14
Alrestatin
-
Ovis aries
1.1.1.14
Berberine
-
Ovis aries
1.1.1.14
bis-diethylthiocarbamoyldisulfide
-
Ovis aries
1.1.1.14
butanedioic acid
at pH 9.9
Ovis aries
1.1.1.14
Cibacron Blue 3G-A
-
Ovis aries
1.1.1.14
cyanamide
at pH 9.9
Ovis aries
1.1.1.14
cysteamine
significant only at pH 9.9
Ovis aries
1.1.1.14
cysteine
-
Ovis aries
1.1.1.14
Decanoic acid
at pH 9.9
Ovis aries
1.1.1.14
Diethylthiocarbamate
at pH 9.9
Ovis aries
1.1.1.14
dithiothreitol
-
Ovis aries
1.1.1.14
DL-2-thiovaline
-
Ovis aries
1.1.1.14
Eriochrome Black T
-
Ovis aries
1.1.1.14
ethanedioic acid
at pH 9.9
Ovis aries
1.1.1.14
ICI 171071
-
Ovis aries
1.1.1.14
ICI 222155
-
Ovis aries
1.1.1.14
imidazole
-
Ovis aries
1.1.1.14
Isonicotinic acid hydrazide
-
Ovis aries
1.1.1.14
ponalrestat
-
Ovis aries
1.1.1.14
propanedioic acid
at pH 9.9
Ovis aries
1.1.1.14
pyrazole
-
Ovis aries
1.1.1.14
quercetin
at pH 7.4
Ovis aries
1.1.1.14
thioacetate
at pH 9.9
Ovis aries
1.1.1.14
thiocyanate
at pH 9.9
Ovis aries
1.1.1.14
Thiourea
at pH 9.9
Ovis aries
1.1.1.14
Tolrestat
-
Ovis aries
1.1.1.14
Urea
at pH 9.9
Ovis aries
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.1.1.14
liver
-
Ovis aries
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.14
D-sorbitol + NAD+
-
285889
Ovis aries
D-fructose + NADH + H+
-
-
-
-