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Literature summary extracted from

  • Hanschmann, H.; Ehricht, R.; Kleber, H.P.
    Purification and properties of L(-)-carnitine dehydrogenase from Agrobacterium sp. (1996), Biochim. Biophys. Acta, 1290, 177-183.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.108 Cu2+ L-carnitine dehydrogenase, complete inhibition Agrobacterium sp.
1.1.1.108 Hg2+ L-carnitine dehydrogenase, complete inhibition Agrobacterium sp.
1.1.1.108 trimethylamine L-carnitine dehydrogenase, strong inhibition Agrobacterium sp.

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.108 0.018
-
NAD+ L-carnitine dehydrogenase, two different forms of the enzyme or two binding sites Agrobacterium sp.
1.1.1.108 0.032
-
NADH L-carnitine dehydrogenase Agrobacterium sp.
1.1.1.108 0.042
-
NAD+ L-carnitine dehydrogenase, two different forms of the enzyme or two binding sites Agrobacterium sp.
1.1.1.108 0.14
-
NAD+
-
Alcaligenes sp.
1.1.1.108 0.29
-
L-carnitine L-carnitine dehydrogenase, two different forms of the enzyme or two binding sites Agrobacterium sp.
1.1.1.108 0.72
-
3-dehydrocarnitine L-carnitine dehydrogenase Agrobacterium sp.
1.1.1.108 6.1
-
L-carnitine L-carnitine dehydrogenase, two different forms of the enzyme or two binding sites Agrobacterium sp.
1.1.1.108 9.3
-
L-carnitine
-
Alcaligenes sp.

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.108 51000
-
gel filtration Alcaligenes sp.
1.1.1.108 57000
-
2 * 57000, L-carnitine dehydrogenase, SDS-PAGE Agrobacterium sp.
1.1.1.108 114000
-
gel filtration, L-carnitine dehydrogenase Agrobacterium sp.

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.108 (R)-3-hydroxy-4-trimethylaminobutyrate + NAD+ Pseudomonas putida
-
3-dehydrocarnitine + NADH + H+
-
r
1.1.1.108 (R)-3-hydroxy-4-trimethylaminobutyrate + NAD+ Alcaligenes sp.
-
3-dehydrocarnitine + NADH + H+
-
r
1.1.1.108 (R)-3-hydroxy-4-trimethylaminobutyrate + NAD+ Agrobacterium sp.
-
3-dehydrocarnitine + NADH + H+
-
r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.108 Agrobacterium sp.
-
DSM 8888, D-carnitine- and L-carnitine dehydrogenases are induced by D-carnitine and L-carnitine respectively
-
1.1.1.108 Alcaligenes sp.
-
-
-
1.1.1.108 Pseudomonas putida
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.108 DEAE-Sepharose FF, Blue-Sepharose, Superose 12HR, Fractogel TSK Butyl, L-carnitine dehydrogenase Agrobacterium sp.

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.108 16.75
-
L-carnitine dehydrogenase Agrobacterium sp.

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.108 (R)-3-hydroxy-4-trimethylaminobutyrate + NAD+
-
Pseudomonas putida 3-dehydrocarnitine + NADH + H+
-
r
1.1.1.108 (R)-3-hydroxy-4-trimethylaminobutyrate + NAD+
-
Alcaligenes sp. 3-dehydrocarnitine + NADH + H+
-
r
1.1.1.108 (R)-3-hydroxy-4-trimethylaminobutyrate + NAD+
-
Agrobacterium sp. 3-dehydrocarnitine + NADH + H+
-
r
1.1.1.108 carnitine + NAD+
-
Pseudomonas putida 3-dehydrocarnitine + NADH + H+
-
r
1.1.1.108 carnitine + NAD+
-
Alcaligenes sp. 3-dehydrocarnitine + NADH + H+
-
r
1.1.1.108 carnitine + NAD+
-
Agrobacterium sp. 3-dehydrocarnitine + NADH + H+
-
r
1.1.1.108 carnitine amide + NAD+ L-carnitine dehydrogenase, weak activity Agrobacterium sp. 3-dehydrocarnitine amide + NADH + H+
-
?

Subunits

EC Number Subunits Comment Organism
1.1.1.108 dimer 2 * 57000, L-carnitine dehydrogenase, SDS-PAGE Agrobacterium sp.

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.108 45
-
L-carnitine dehydrogenase Agrobacterium sp.
1.1.1.108 50
-
-
Alcaligenes sp.

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.108 5.6 6.5 L-carnitine dehydrogenase, oxidation of L-carnitine Agrobacterium sp.
1.1.1.108 9
-
oxidation of L-carnitine Alcaligenes sp.
1.1.1.108 9.5
-
L-carnitine dehydrogenase, oxidation of L-carnitine Agrobacterium sp.

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.108 NAD+
-
Pseudomonas putida
1.1.1.108 NAD+
-
Alcaligenes sp.
1.1.1.108 NAD+
-
Agrobacterium sp.