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Literature summary extracted from

  • Leo, M.A.; Lieber, C.S.
    NAD+-dependent retinol dehydrogenase in liver microsomes (1990), Methods Enzymol., 189, 520-524.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.105 BigCHAP 10-20% stimulation Rattus norvegicus

General Stability

EC Number General Stability Organism
1.1.1.105 repeated freezing and thawing strikingly affects activity Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.105 Chloral hydrate
-
 Rattus norvegicus
1.1.1.105 Lubrol Px
-
 Rattus norvegicus
1.1.1.105 sodium deoxycholate
-
 Rattus norvegicus
1.1.1.105 Triton X-100
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.105 0.12
-
 retinol
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.105 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.105 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.105 retinal + NADH
-
 Rattus norvegicus retinol + NAD+
-
 r
1.1.1.105 retinal + NADPH + H+ activity is lower than with NADH Rattus norvegicus retinol + NADP+
-
 ?
1.1.1.105 retinol + NAD+
-
 Rattus norvegicus retinal + NADH
-
 r

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.105 additional information
-
 maximal activity at physiological pH Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.105 NAD+ cofactor Rattus norvegicus
1.1.1.105 NADH cofactor Rattus norvegicus