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Literature summary extracted from
- Studies on liver threonine dehydrogenase (1964), Arch. Biochem. Biophys., 105, 173-178.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.103 | Hg2+ | 0.25 mM, complete inhibition, 0.05 mM, 95% inhibition | Lithobates catesbeianus |  |
| 1.1.1.103 | iodoacetamide | 30 mM, 15% inhibition | Lithobates catesbeianus | |
| 1.1.1.103 | Iodosobenzoic acid | 0.3 mM, 17% inhibition | Lithobates catesbeianus | |
| 1.1.1.103 | p-chloromercuribenzoate | complete inhibition | Lithobates catesbeianus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.103 | 0.24 | - |
NAD+ | - |
Lithobates catesbeianus | |
| 1.1.1.103 | 6.1 | - |
L-threonine | - |
Lithobates catesbeianus | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.103 | L-threonine + NAD+ | Lithobates catesbeianus | - |
(2S)-2-amino-3-oxobutanoate + NADH + H+ | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.103 | Lithobates catesbeianus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.1.1.103 | ammonium sulfate, DEAE-cellulose, 7fold purification | Lithobates catesbeianus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.1.1.103 | liver | - |
Lithobates catesbeianus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.103 | 339 | - |
- |
Lithobates catesbeianus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.103 | L-threonine + NAD+ | - |
Lithobates catesbeianus | (2S)-2-amino-3-oxobutanoate + NADH + H+ | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.103 | 7.8 | - |
- |
Lithobates catesbeianus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.103 | NAD+ | - |
Lithobates catesbeianus | |
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Release 2023.1 (January 2023)
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