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Literature summary extracted from

  • LaBelle, E.F.; Hajra, A.K.
    Enzymatic reduction of alkyl and acyl derivatives of dihydroxyacetone phosphate by reduced pyridine nucleotides (1972), J. Biol. Chem., 247, 5825-5834.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.101 EDTA activation, acyldihydroxyacetone phosphate as substrate Cavia porcellus
1.1.1.101 EDTA activation, acyldihydroxyacetone phosphate as substrate Rattus norvegicus

General Stability

EC Number General Stability Organism
1.1.1.101 freeze-thawing, stable after several cycles Cavia porcellus
1.1.1.101 freeze-thawing, stable after several cycles Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.101 0.005
-
 NADPH cosubstrate hexadecyldihydroxyacetone phosphate, brain Rattus norvegicus
1.1.1.101 0.007
-
 NADPH cosubstrate palmitoyldihydroxyacetone phosphate, brain Rattus norvegicus
1.1.1.101 0.01
-
 NADPH ascites microsomes Cavia porcellus
1.1.1.101 0.01
-
 NADPH ascites microsomes Rattus norvegicus
1.1.1.101 0.05
-
 NADPH liver mitochondria Cavia porcellus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.101 acyldihydroxyacetone phosphate + NADPH Cavia porcellus reaction in non-ether lipids biosynthesis 1-acyl-sn-glycerol 3-phosphate + NADP+
-
 ?
1.1.1.101 acyldihydroxyacetone phosphate + NADPH Rattus norvegicus reaction in non-ether lipids biosynthesis 1-acyl-sn-glycerol 3-phosphate + NADP+
-
 ?
1.1.1.101 alkyldihydroxyacetone phosphate + NADPH + H+ Cavia porcellus reaction in ether lipids biosynthesis 1-alkyl-sn-glycerol 3-phosphate + NADP+
-
 ?
1.1.1.101 alkyldihydroxyacetone phosphate + NADPH + H+ Rattus norvegicus reaction in ether lipids biosynthesis 1-alkyl-sn-glycerol 3-phosphate + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.101 Cavia porcellus
-
-
-
1.1.1.101 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.101 adipose tissue
-
 Rattus norvegicus
-
1.1.1.101 ascites tumor cell grown in the abdomen of swiss white mice Cavia porcellus
-
1.1.1.101 ascites tumor cell grown in the abdomen of swiss white mice Rattus norvegicus
-
1.1.1.101 brain
-
 Rattus norvegicus
-
1.1.1.101 heart
-
 Rattus norvegicus
-
1.1.1.101 kidney
-
 Rattus norvegicus
-
1.1.1.101 liver
-
 Cavia porcellus
-
1.1.1.101 liver
-
 Rattus norvegicus
-
1.1.1.101 lung
-
 Cavia porcellus
-
1.1.1.101 spleen
-
 Cavia porcellus
-
1.1.1.101 testis
-
 Cavia porcellus
-
1.1.1.101 testis
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.101 acyldihydroxyacetone phosphate + NADPH
-
 Cavia porcellus 1-acyl-sn-glycerol 3-phosphate + NADP+
-
 ?
1.1.1.101 acyldihydroxyacetone phosphate + NADPH
-
 Rattus norvegicus 1-acyl-sn-glycerol 3-phosphate + NADP+
-
 ?
1.1.1.101 acyldihydroxyacetone phosphate + NADPH reaction in non-ether lipids biosynthesis Cavia porcellus 1-acyl-sn-glycerol 3-phosphate + NADP+
-
 ?
1.1.1.101 acyldihydroxyacetone phosphate + NADPH reaction in non-ether lipids biosynthesis Rattus norvegicus 1-acyl-sn-glycerol 3-phosphate + NADP+
-
 ?
1.1.1.101 alkyldihydroxyacetone phosphate + NADPH + H+
-
 Cavia porcellus 1-alkyl-sn-glycerol 3-phosphate + NADP+
-
 ?
1.1.1.101 alkyldihydroxyacetone phosphate + NADPH + H+
-
 Rattus norvegicus 1-alkyl-sn-glycerol 3-phosphate + NADP+
-
 ?
1.1.1.101 alkyldihydroxyacetone phosphate + NADPH + H+ reaction in ether lipids biosynthesis Cavia porcellus 1-alkyl-sn-glycerol 3-phosphate + NADP+
-
 ?
1.1.1.101 alkyldihydroxyacetone phosphate + NADPH + H+ reaction in ether lipids biosynthesis Rattus norvegicus 1-alkyl-sn-glycerol 3-phosphate + NADP+
-
 ?
1.1.1.101 hexadecyldihydroxyacetone phosphate + NADPH
-
 Cavia porcellus 1-hexadecyl-sn-glycerol 3-phosphate + NADP+
-
 ?
1.1.1.101 hexadecyldihydroxyacetone phosphate + NADPH
-
 Rattus norvegicus 1-hexadecyl-sn-glycerol 3-phosphate + NADP+
-
 ?
1.1.1.101 palmitoylglycerone phosphate + NADPH i.e. palmitoyldihydroxyacetone phosphate Cavia porcellus 1-palmitoylglycerol 3-phosphate + NADP+
-
 ?
1.1.1.101 palmitoylglycerone phosphate + NADPH i.e. palmitoyldihydroxyacetone phosphate Rattus norvegicus 1-palmitoylglycerol 3-phosphate + NADP+
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.1.1.101 100
-
 complete inactivation after 10 min Cavia porcellus
1.1.1.101 100
-
 complete inactivation after 10 min Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.101 6.5 7.5 broad optimum Cavia porcellus
1.1.1.101 6.5 7.5 broad optimum Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.101 NADH
-
 Cavia porcellus
1.1.1.101 NADH at high concentrations, rat liver Rattus norvegicus
1.1.1.101 NADPH specific for NADPH Cavia porcellus
1.1.1.101 NADPH specific for NADPH Rattus norvegicus
1.1.1.101 NADPH hydrogen from B-side of nicotinamide ring is transferred to reduce keto substrates Cavia porcellus
1.1.1.101 NADPH hydrogen from B-side of nicotinamide ring is transferred to reduce keto substrates Rattus norvegicus