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Literature summary extracted from

  • Fisher, M.; Kroon, J.T.M.; Martindale, W.; Stuitje, A.R.; Slabas, A.R.; Rafferty, J.B.
    The x-ray structure of Brassica napus beta-keto acyl carrier protein reductase and its implications for substrate binding and catalysis (2000), Structure, 8, 339-347.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.1.1.100 structure determination and similarities within short-chain alcohol dehydrogenase family, catalytic mechanism Brassica napus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.100 3-oxoacyl-[acyl-carrier protein] + NADPH Escherichia coli
-
 (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
-
 ?
1.1.1.100 3-oxoacyl-[acyl-carrier protein] + NADPH Brassica napus enzyme is part of the dissociable fatty acid synthase type II multienzyme complex for de novo synthesis of fatty acids from acetyl-CoA and malonyl-CoA (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
-
 ?
1.1.1.100 3-oxoacyl-[acyl-carrier protein] + NADPH Brassica napus enzyme in fatty acid synthesis (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
-
 ?
1.1.1.100 additional information Escherichia coli catalyzes also the reduction of the beta-keto group of unsaturated acyl chains during biosynthesis of unsaturated fatty acids ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.100 Brassica napus
-
-
-
1.1.1.100 Escherichia coli
-
-
-
1.3.1.9 Brassica napus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.1.1.100 a (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = a 3-oxoacyl-[acyl-carrier protein] + NADPH + H+ belongs to family of short-chain alcohol dehydrogenases (SDR) with catalytic triad Ser154, Tyr167 and Lys171, catalytic mechanism Brassica napus
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.100 3-oxoacyl-[acyl-carrier protein] + NADPH
-
 Escherichia coli (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
-
 ?
1.1.1.100 3-oxoacyl-[acyl-carrier protein] + NADPH belongs to family of short-chain alcohol dehydrogenases (SDR) with catalytic triade Ser154, Tyr167 and Lys171, catalytic mechanism Brassica napus (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
-
 ?
1.1.1.100 3-oxoacyl-[acyl-carrier protein] + NADPH enzyme is part of the dissociable fatty acid synthase type II multienzyme complex for de novo synthesis of fatty acids from acetyl-CoA and malonyl-CoA Brassica napus (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
-
 ?
1.1.1.100 3-oxoacyl-[acyl-carrier protein] + NADPH enzyme in fatty acid synthesis Brassica napus (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
-
 ?
1.1.1.100 acetoacetyl-CoA + NADPH + H+
-
 Escherichia coli D-beta-hydroxybutyryl-CoA + NADP+
-
 ?
1.1.1.100 acetoacetyl-CoA + NADPH + H+
-
 Brassica napus D-beta-hydroxybutyryl-CoA + NADP+
-
 ?
1.1.1.100 acetoacetyl-N-cysteamine + NADPH
-
 Escherichia coli D-3-hydroxybutyryl-N-cysteamine + NADP+
-
 ?
1.1.1.100 acetoacetyl-N-cysteamine + NADPH
-
 Brassica napus D-3-hydroxybutyryl-N-cysteamine + NADP+
-
 ?
1.1.1.100 acetoacetyl-[acyl-carrier protein] + NADPH
-
 Escherichia coli D-beta-hydroxybutyryl-[acyl-carrier protein] + NADP+
-
 ?
1.1.1.100 acetoacetyl-[acyl-carrier protein] + NADPH
-
 Brassica napus D-beta-hydroxybutyryl-[acyl-carrier protein] + NADP+
-
 ?
1.1.1.100 additional information catalyzes also the reduction of the beta-keto group of unsaturated acyl chains during biosynthesis of unsaturated fatty acids Escherichia coli ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.100 BKR
-
 Escherichia coli
1.1.1.100 BKR
-
 Brassica napus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.100 NADPH absolute specificity for NADPH Escherichia coli
1.1.1.100 NADPH absolute specificity for NADPH Brassica napus