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Literature summary extracted from

  • Burnell, J.C.; Li, T.K.; Bosron, W.F.
    Purification and steady-state kinetic characterization of human liver beta 3 beta 3 alcohol dehydrogenase (1989), Biochemistry, 28, 6810-6815.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.1 0.022
-
 ethanol isoenzyme beta1,beta1, 0.1 M sodium phosphate buffer, pH 7.5, at 25 °C Homo sapiens
1.1.1.1 0.085
-
 acetaldehyde isoenzyme beta1,beta1, 0.1 M sodium phosphate buffer, pH 7.5, at 25 °C Homo sapiens
1.1.1.1 0.24
-
 acetaldehyde isoenzyme beta2,beta2, 0.1 M sodium phosphate buffer, pH 7.5, 25°C Homo sapiens
1.1.1.1 0.84
-
 ethanol isoenzyme beta2,beta2, 0.1 M sodium phosphate buffer, pH 7.5, 25°C Homo sapiens
1.1.1.1 3.4
-
 acetaldehyde isoenzyme beta3,beta3, 0.1 M sodium phospahte buffer, pH 7.5, 25°C Homo sapiens
1.1.1.1 6.4
-
 NADH isoenzyme beta1,beta1, 0.1 M sodium phosphate buffer, pH 7.5, at 25 °C Homo sapiens
1.1.1.1 7.4
-
 NAD+ isoenzyme beta1,beta1, 0.1 M sodium phosphate buffer, pH 7.5, at 25 °C Homo sapiens
1.1.1.1 36
-
 ethanol isoenzyme beta3,beta3, 0.1 M sodium phospahte buffer, pH 7.5, 25°C Homo sapiens
1.1.1.1 105
-
 NADH isoenzyme beta2,beta2, 0.1 M sodium phosphate buffer, pH 7.5, 25°C Homo sapiens
1.1.1.1 180
-
 NAD+ isoenzyme beta2,beta2, 0.1 M sodium phosphate buffer, pH 7.5, 25°C Homo sapiens
1.1.1.1 260
-
 NADH isoenzyme beta3,beta3, 0.1 M sodium phospahte buffer, pH 7.5, 25°C Homo sapiens
1.1.1.1 710
-
 NAD+ isoenzyme beta3,beta3, 0.1 M sodium phospahte buffer, pH 7.5, 25°C Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.1 Homo sapiens
-
 isoenzymes beta1,beta1, beta2,beta2 and beta3,beta3
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.1 isoenzyme beta3,beta3 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.1 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.1 butan-2-ol + NAD+
-
 Homo sapiens butan-2-one + NADH
-
 ?
1.1.1.1 butanol + NAD+
-
 Homo sapiens butyraldehyde + NADH
-
 ?
1.1.1.1 ethanol + NAD+
-
 Homo sapiens acetaldehyde + NADH
-
 ?
1.1.1.1 hexanol + NAD+
-
 Homo sapiens n-hexanal + NADH
-
 ?
1.1.1.1 isobutyl alcohol + NAD+
-
 Homo sapiens ? + NADH
-
 ?
1.1.1.1 isopentenyl alcohol + NAD+
-
 Homo sapiens isopentanone + NADH
-
 ?
1.1.1.1 methanol + NAD+ no activity with isoenzyme beta3,beta3 Homo sapiens formaldehyde + NADH + H+
-
 ?
1.1.1.1 methanol + NAD+ oxidized by isoenzyme beta1,beta1 Homo sapiens formaldehyde + NADH + H+
-
 ?
1.1.1.1 pentanal + NAD+
-
 Homo sapiens pentanone + NADH
-
 ?
1.1.1.1 propanol + NAD+
-
 Homo sapiens propionaldehyde + NADH + H+
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.1 7
-
 isoenzyme beta3,beta3 Homo sapiens
1.1.1.1 8.5
-
 isoenzyme beta2,beta2 Homo sapiens
1.1.1.1 10.5
-
 isoenzyme beta1,beta1 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.1 NAD+
-
 Homo sapiens
1.1.1.1 NADH
-
 Homo sapiens