Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Wagner, F.W.; Burger, A.R.; Vallee, B.L.
    Kinetic properties of human liver alcohol dehydrogenase: oxidation of alcohols by class I isoenzymes (1983), Biochemistry, 22, 1857-1863.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.1 additional information
-
additional information Km values for the class I isoenzymes with the substrates ethanol, methanol, ethylene glycol, benzyl alcohol, octanol, cyclohexanol and 16-hydroxyhexadecanoic acid Homo sapiens
1.1.1.1 0.008
-
Cyclohexanol isoenzyme alpha,gamma1 Homo sapiens
1.1.1.1 0.08
-
Octanol isoenzyme alpha,gamma1 Homo sapiens
1.1.1.1 1.7
-
ethanol isoenzyme alpha,gamma1 Homo sapiens
1.1.1.1 23
-
Cyclohexanol isoenzyme beta1,beta1 Homo sapiens
1.1.1.1 50
-
ethylene glycol isoenzyme alpha,gamma1 Homo sapiens
1.1.1.1 150
-
methanol isoenzyme alpha,gamma1 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.1 Homo sapiens
-
class I isoenzymes: alpha,gamma2, gamma2gamma2, alpha,gamma1, alpha,beta1, beta1,gamma2, gamma1,gamma1, beta1,gamma1, beta1,beta1
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.1 class I isoenzymes Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.1 liver
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.1 16-hydroxyhexadecanoate + NAD+
-
Homo sapiens 16-oxohexadecanoic acid + NADH
-
?
1.1.1.1 3-phenyl-1-propanol + NAD+
-
Homo sapiens 3-phenyl-1-propanone + NADH
-
?
1.1.1.1 benzyl alcohol + NAD+
-
Homo sapiens benzaldehyde + NADH
-
?
1.1.1.1 cyclohexanol + NAD+
-
Homo sapiens cyclohexanone + NADH
-
?
1.1.1.1 ethanol + NAD+
-
Homo sapiens acetaldehyde + NADH
-
?
1.1.1.1 ethylene glycol + NAD+
-
Homo sapiens ? + NADH
-
?
1.1.1.1 methanol + NAD+ class I isoenzymes Homo sapiens formaldehyde + NADH + H+
-
?
1.1.1.1 octan-1-ol + NAD+
-
Homo sapiens n-octanal + NADH
-
?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.1.1.1 additional information
-
additional information turnover-numbers for the class I isoenzymes with the substrates ethanol, methanol, ethylene glycol, benzyl alcohol, octanol, cyclohexanol and 16-hydroxyhexadecanoic acid Homo sapiens
1.1.1.1 3.83
-
ethanol isoenzyme gamma1,gamma1 Homo sapiens
1.1.1.1 4
-
ethanol isoenzyme alpha,gamma1 Homo sapiens
1.1.1.1 4.33
-
Octanol isoenzyme alpha,gamma1 Homo sapiens
1.1.1.1 4.67
-
benzyl alcohol isoenzyme alpha,gamma1 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.1 NAD+
-
Homo sapiens
1.1.1.1 NADH
-
Homo sapiens