Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Zhao, X.J.; Ishizaki, T.
    The in vitro hepatic metabolism of quinine in mice, rats and dogs: comparison with human liver microsomes (1997), J. Pharmacol. Exp. Ther., 283, 1168-1176.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.14.55 alpha-naphthoflavone
-
 Homo sapiens
1.14.14.55 alpha-naphthoflavone
-
 Canis lupus familiaris
1.14.14.55 diazepam
-
 Homo sapiens
1.14.14.55 diazepam
-
 Canis lupus familiaris

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.55 alpha-naphthoflavone
-
 Mus musculus
1.14.14.55 alpha-naphthoflavone
-
 Rattus norvegicus
1.14.14.55 anti-CYP3A4 antibodies inhibition of 92% Canis lupus familiaris
1.14.14.55 anti-CYP3A4 antibodies
-
 Homo sapiens
1.14.14.55 anti-CYP3A4 antibodies inhibition of 96% Mus musculus
1.14.14.55 anti-CYP3A4 antibodies inhibition of 84% Rattus norvegicus
1.14.14.55 Chloroquin
-
 Canis lupus familiaris
1.14.14.55 Chloroquin
-
 Rattus norvegicus
1.14.14.55 diazepam
-
 Mus musculus
1.14.14.55 diazepam
-
 Rattus norvegicus
1.14.14.55 doxycyclin
-
 Canis lupus familiaris
1.14.14.55 doxycyclin
-
 Homo sapiens
1.14.14.55 doxycyclin
-
 Rattus norvegicus
1.14.14.55 ketoconazole maximum inhibition of 88% Canis lupus familiaris
1.14.14.55 ketoconazole maximum inhibition of 90% Homo sapiens
1.14.14.55 ketoconazole maximum inhibition of 94% Mus musculus
1.14.14.55 ketoconazole maximum inhibition of 91% Rattus norvegicus
1.14.14.55 p-nitrophenol inhibition observed but not quantified Homo sapiens
1.14.14.55 p-nitrophenol inhibits more than 75% at 10 mM Mus musculus
1.14.14.55 primaquine
-
 Canis lupus familiaris
1.14.14.55 primaquine
-
 Homo sapiens
1.14.14.55 primaquine
-
 Rattus norvegicus
1.14.14.55 S-mephenytoin
-
 Homo sapiens
1.14.14.55 S-mephenytoin inhibits more than 70% at 0.5 mM Mus musculus
1.14.14.55 sulfaphenazole inhibits more than 50% at 0.1 mM Mus musculus
1.14.14.55 tetracyclin
-
 Canis lupus familiaris
1.14.14.55 tetracyclin
-
 Homo sapiens
1.14.14.55 tetracyclin
-
 Rattus norvegicus
1.14.14.55 troleandomycin maximum inhibition of 93% Canis lupus familiaris
1.14.14.55 troleandomycin maximum inhibition of 70% Homo sapiens
1.14.14.55 troleandomycin maximum inhibition of 85% Mus musculus
1.14.14.55 troleandomycin maximum inhibition of 66% Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.14.55 0.0227
-
 Quinine
-
 Rattus norvegicus
1.14.14.55 0.0297
-
 Quinine
-
 Mus musculus
1.14.14.55 0.105
-
 Quinine
-
 Homo sapiens
1.14.14.55 0.138
-
 Quinine
-
 Canis lupus familiaris

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.55 microsome
-
 Mus musculus
-
-
1.14.14.55 microsome
-
 Homo sapiens
-
-
1.14.14.55 microsome
-
 Rattus norvegicus
-
-
1.14.14.55 microsome
-
 Canis lupus familiaris
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.55 Canis lupus familiaris
-
 dog
-
1.14.14.55 Homo sapiens
-
 human
-
1.14.14.55 Mus musculus
-
 mouse
-
1.14.14.55 Rattus norvegicus
-
 rat
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.55 liver
-
 Mus musculus
-
1.14.14.55 liver
-
 Homo sapiens
-
1.14.14.55 liver
-
 Rattus norvegicus
-
1.14.14.55 liver
-
 Canis lupus familiaris
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.55 quinine + NADPH + O2
-
 Mus musculus 3-hydroxyquinine + NADP+ + H2O
-
 ?
1.14.14.55 quinine + NADPH + O2
-
 Homo sapiens 3-hydroxyquinine + NADP+ + H2O
-
 ?
1.14.14.55 quinine + NADPH + O2
-
 Rattus norvegicus 3-hydroxyquinine + NADP+ + H2O
-
 ?
1.14.14.55 quinine + NADPH + O2
-
 Canis lupus familiaris 3-hydroxyquinine + NADP+ + H2O
-
 ?