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Literature summary extracted from

  • Rush, W.R.; Gibson, G.G.; Parke, D.V.
    The purification and reconstitution of cytochrome P-450-dependent cholesterol 7alpha-hydroxylase activity from rat liver microsomal fractions (1980), Biochem. Soc. Trans., 8, 102-103.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.23 microsome
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.23 cholesterol + [reduced NADPH-hemoprotein reductase] + O2 Rattus norvegicus rate-limiting step in bile acid formation 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.23 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.14.14.23 additional information enzyme has a partial requirement for phospholipid Rattus norvegicus

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.14.23
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.23 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.23 cholesterol + [reduced NADPH-hemoprotein reductase] + O2
-
 Rattus norvegicus 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.23 cholesterol + [reduced NADPH-hemoprotein reductase] + O2 rate-limiting step in bile acid formation Rattus norvegicus 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.23 heme cytochrome P-450 dependent enzyme Rattus norvegicus
1.14.14.23 NADPH
-
 Rattus norvegicus