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Literature summary extracted from

  • Proudfoot, A.E.I.; Payton, M.A.; Wells, N.C.
    Purification and characterization of fungal and mammalian phosphomannose isomerases (1994), J. Protein Chem., 13, 619-627.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.3.1.8 1,10-phenanthroline
-
 Candida albicans
5.3.1.8 1,10-phenanthroline
-
 Homo sapiens
5.3.1.8 1,10-phenanthroline
-
 Saccharomyces cerevisiae
5.3.1.8 1,10-phenanthroline
-
 Sus scrofa
5.3.1.8 arabinose 5-phosphate
-
 Candida albicans
5.3.1.8 arabinose 5-phosphate
-
 Homo sapiens
5.3.1.8 arabinose 5-phosphate
-
 Saccharomyces cerevisiae
5.3.1.8 arabinose 5-phosphate
-
 Sus scrofa
5.3.1.8 dithiothreitol
-
 Candida albicans
5.3.1.8 dithiothreitol
-
 Homo sapiens
5.3.1.8 dithiothreitol
-
 Saccharomyces cerevisiae
5.3.1.8 dithiothreitol
-
 Sus scrofa
5.3.1.8 EDTA
-
 Candida albicans
5.3.1.8 EDTA
-
 Homo sapiens
5.3.1.8 EDTA
-
 Saccharomyces cerevisiae
5.3.1.8 EDTA
-
 Sus scrofa
5.3.1.8 erythrose 4-phosphate
-
 Candida albicans
5.3.1.8 erythrose 4-phosphate
-
 Homo sapiens
5.3.1.8 erythrose 4-phosphate
-
 Saccharomyces cerevisiae
5.3.1.8 erythrose 4-phosphate
-
 Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
5.3.1.8 0.17
-
 mannose 6-phosphate
-
 Sus scrofa
5.3.1.8 0.25
-
 mannose 6-phosphate wild-type enzyme Homo sapiens
5.3.1.8 0.65
-
 mannose 6-phosphate
-
 Saccharomyces cerevisiae
5.3.1.8 1.24
-
 mannose 6-phosphate
-
 Candida albicans

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
5.3.1.8 Zinc
-
 Saccharomyces cerevisiae
5.3.1.8 Zinc recombinant enzyme expressed in E. coli contains slightly less than 1 mol of zinc per mol of proteins Homo sapiens
5.3.1.8 Zinc recombinant enzyme expressed in E. coli contains slightly less than 1 mol of zinc per mol of proteins Candida albicans

Organism

EC Number Organism UniProt Comment Textmining
5.3.1.8 Candida albicans
-
-
-
5.3.1.8 Homo sapiens
-
-
-
5.3.1.8 Saccharomyces cerevisiae
-
-
-
5.3.1.8 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.3.1.8
-
 Homo sapiens
5.3.1.8
-
 Sus scrofa
5.3.1.8
-
 Saccharomyces cerevisiae
5.3.1.8
-
 Candida albicans

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
5.3.1.8 75
-
-
 Homo sapiens
5.3.1.8 80
-
-
 Sus scrofa
5.3.1.8 380
-
-
 Candida albicans
5.3.1.8 420
-
-
 Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.1.8 D-Mannose 6-phosphate
-
 Homo sapiens D-Fructose 6-phosphate
-
 ?
5.3.1.8 D-Mannose 6-phosphate
-
 Sus scrofa D-Fructose 6-phosphate
-
 ?
5.3.1.8 D-Mannose 6-phosphate
-
 Saccharomyces cerevisiae D-Fructose 6-phosphate
-
 ?
5.3.1.8 D-Mannose 6-phosphate
-
 Candida albicans D-Fructose 6-phosphate
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
5.3.1.8 6.5 8
-
 Homo sapiens
5.3.1.8 6.5 8
-
 Sus scrofa
5.3.1.8 6.5 8
-
 Saccharomyces cerevisiae
5.3.1.8 6.5 8
-
 Candida albicans