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Literature summary extracted from

  • Cleasby, A.; Wonacott, A.; Skarzynski, T.; Hubbard, R.E.; Davies, G.J.; Proudfoot, A.E.I.; Bernard, A.R.; Payton, M.A.; Wells, T.N.C.
    The X-ray crystal structure of phosphomannose isomerase from Candida albicans at 1.7 A resolution (1996), Nat. Struct. Biol., 3, 470-479.
    View publication on PubMed

Application

EC Number Application Comment Organism
5.3.1.8 pharmacology absence of mannose-6-phosphate isomerase causes cell lysis and thus the enzyme is a potential target for inhibition and may be a route to antifungal drugs Candida albicans

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
5.3.1.8
-
Candida albicans

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
5.3.1.8 Zinc enzyme contains an essential zinc atom. Four of the five ligands come from the protein, one of these ligands is unique in that it is a glutamine Candida albicans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.3.1.8 additional information Candida albicans reversible isomerization of mannose 6-phosphate and fructose 6-phosphate is the initial commited step in the synthesis of the mannosylated glycoproteins, which are essential in biosynthesis of functional fungal cell wall. Absence of mannose-6-phosphate isomerase causes cell lysis ?
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?

Organism

EC Number Organism UniProt Comment Textmining
5.3.1.8 Candida albicans
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.1.8 D-Mannose 6-phosphate
-
Candida albicans D-Fructose 6-phosphate
-
?
5.3.1.8 additional information reversible isomerization of mannose 6-phosphate and fructose 6-phosphate is the initial commited step in the synthesis of the mannosylated glycoproteins, which are essential in biosynthesis of functional fungal cell wall. Absence of mannose-6-phosphate isomerase causes cell lysis Candida albicans ?
-
?