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Literature summary extracted from
- Comparative kinetics of D-xylose and D-glucose isomerase activities of the D-xylose isomerase from Thermus aquaticus HB8 (1990), Biol. Chem. Hoppe-Seyler, 371, 527-536.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.3.1.5 | 2-O-Methyl-D-xylose | - |
Thermus aquaticus |  |
| 5.3.1.5 | Ca2+ | weak inhibition | Thermus aquaticus | |
| 5.3.1.5 | Cu2+ | strong inhibition | Thermus aquaticus | |
| 5.3.1.5 | D-Lyxose | - |
Thermus aquaticus | |
| 5.3.1.5 | D-xylitol | - |
Thermus aquaticus | |
| 5.3.1.5 | Fe2+ | weak inhibition | Thermus aquaticus | |
| 5.3.1.5 | Hg2+ | no influence on activity | Thermus aquaticus | |
| 5.3.1.5 | Ni2+ | weak inhibition | Thermus aquaticus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 5.3.1.5 | 8 | - |
D-xylulose | - |
Thermus aquaticus | |
| 5.3.1.5 | 15 | - |
D-xylose | - |
Thermus aquaticus | |
| 5.3.1.5 | 93 | - |
D-xylose | D-glucose | Thermus aquaticus | |
| 5.3.1.5 | 145 | - |
D-ribose | - |
Thermus aquaticus | |
| 5.3.1.5 | 151 | - |
D-arabinose | - |
Thermus aquaticus | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.3.1.5 | Co2+ | most effective activator of D-glucose isomerization | Thermus aquaticus | |
| 5.3.1.5 | Mg2+ | activates D-glucose isomerization, D-xylose isomerization and D-ribose isomerization | Thermus aquaticus | |
| 5.3.1.5 | Mn2+ | most effectively activates D-xylose isomerization | Thermus aquaticus | |
| 5.3.1.5 | Zn2+ | activates D-xylose isomerization | Thermus aquaticus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.3.1.5 | Thermus aquaticus | - |
- |
- |
| 5.3.1.5 | Thermus aquaticus HB8 | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.3.1.5 | D-Arabinose | - |
Thermus aquaticus | ? | - |
? | |
| 5.3.1.5 | D-Arabinose | - |
Thermus aquaticus HB8 | ? | - |
? | |
| 5.3.1.5 | D-Glucose | with low efficiency | Thermus aquaticus | D-Fructose | - |
? | |
| 5.3.1.5 | D-Glucose | with low efficiency | Thermus aquaticus HB8 | D-Fructose | - |
? | |
| 5.3.1.5 | D-Ribose | - |
Thermus aquaticus | ? | - |
? | |
| 5.3.1.5 | D-Ribose | - |
Thermus aquaticus HB8 | ? | - |
? | |
| 5.3.1.5 | D-Xylose | - |
Thermus aquaticus | D-Xylulose | - |
? | |
| 5.3.1.5 | D-Xylose | - |
Thermus aquaticus HB8 | D-Xylulose | - |
? | |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 5.3.1.5 | 2.8 | - |
D-xylose | D-ribose | Thermus aquaticus | |
| 5.3.1.5 | 3 | - |
D-arabinose | - |
Thermus aquaticus | |
| 5.3.1.5 | 3.23 | - |
D-glucose | - |
Thermus aquaticus | |
| 5.3.1.5 | 7.7 | - |
D-xylulose | - |
Thermus aquaticus | |
| 5.3.1.5 | 8.6 | - |
D-xylose | - |
Thermus aquaticus | |
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