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Literature summary extracted from

  • Freist, W.; Sternbach, H.; von der Haar, F.; Cramer, F.
    Threonyl-tRNA, lysyl-tRNA and arginyl-tRNA synthetases from baker's yeast. Substrate specificity with regard to ATP analogues (1978), Eur. J. Biochem., 84, 499-502.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.1.1.3 2'-deoxyadenosine 5'-triphosphate
-
 Saccharomyces cerevisiae
6.1.1.3 2'-O-methyladenosine 5'-triphosphate
-
 Saccharomyces cerevisiae
6.1.1.3 3'-Deoxyadenosine 5'-triphosphate
-
 Saccharomyces cerevisiae
6.1.1.3 3'-O-Methyladenosine 5'-triphosphate
-
 Saccharomyces cerevisiae
6.1.1.3 Purineriboside 5'-triphosphate
-
 Saccharomyces cerevisiae
6.1.1.3 tubercidin 5'-triphosphate
-
 Saccharomyces cerevisiae
6.1.1.6 2'-deoxyadenosine 5'-triphosphate
-
 Saccharomyces cerevisiae
6.1.1.6 2'-O-methyladenosine 5'-triphosphate
-
 Saccharomyces cerevisiae
6.1.1.6 3'-Deoxyadenosine 5'-triphosphate
-
 Saccharomyces cerevisiae
6.1.1.6 3'-O-Methyladenosine 5'-triphosphate
-
 Saccharomyces cerevisiae
6.1.1.6 5'-Triphosphates of purine riboside
-
 Saccharomyces cerevisiae
6.1.1.6 8-azidoadenosine
-
 Saccharomyces cerevisiae
6.1.1.6 8-Bromoadenosine
-
 Saccharomyces cerevisiae
6.1.1.6 arabinofuranosyladenosine 5'-triphosphate
-
 Saccharomyces cerevisiae
6.1.1.6 tubercidin 5'-triphosphate
-
 Saccharomyces cerevisiae
6.1.1.19 3'-Deoxyadenosine 5'-triphosphate
-
 Saccharomyces pastorianus
6.1.1.19 8-bromoadenosine 5'-triphosphate
-
 Saccharomyces pastorianus
6.1.1.19 purine-riboside 5'-triphosphate
-
 Saccharomyces pastorianus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.1.1.3 0.4
-
 2-Chloroadenosine 5'-triphosphate
-
 Saccharomyces cerevisiae
6.1.1.3 0.5
-
 Formycin 5'-triphosphate
-
 Saccharomyces cerevisiae
6.1.1.6 0.1
-
 2-Chloroadenosine 5'-triphosphate aminoacylation Saccharomyces cerevisiae
6.1.1.6 0.2
-
 Formycin 5'-triphosphate aminoacylation Saccharomyces cerevisiae
6.1.1.19 0.2
-
 tubercidin 5'-triphosphate formycin 5'-triphosphate, 2'-deoxyadenosine 5'-triphosphate, 3'-O-methyladenosine 5'-triphosphate Saccharomyces pastorianus
6.1.1.19 0.3
-
 ATP 2'-O-methyladenosine 5'-triphosphate Saccharomyces pastorianus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.1.1.6 Mg2+ required Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.3 Saccharomyces cerevisiae
-
-
-
6.1.1.6 Saccharomyces cerevisiae
-
-
-
6.1.1.19 Saccharomyces pastorianus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.3 2-Chloroadenosine 5'-triphosphate + L-threonine + tRNAThr
-
 Saccharomyces cerevisiae ?
-
 ?
6.1.1.3 ATP + L-threonine + tRNAThr
-
 Saccharomyces cerevisiae AMP + diphosphate + L-threonyl-tRNAThr
-
 ?
6.1.1.3 Formycin 5'-triphosphate + L-threonine + tRNAThr
-
 Saccharomyces cerevisiae ?
-
 ?
6.1.1.6 2-chloroadenosine 5'-triphosphate + lysine + tRNALys
-
 Saccharomyces cerevisiae 2-chloroadenosine 5'-monophosphate + Lys-tRNALys + diphosphate
-
 ?
6.1.1.6 ATP + lysine + tRNALys
-
 Saccharomyces cerevisiae AMP + L-lysyl-tRNALys + diphosphate
-
 ?
6.1.1.6 formycin 5'-triphosphate + L-lysine + tRNALys
-
 Saccharomyces cerevisiae formycin 5'-monophosphate + diphosphate + L-lysyl-tRNALys
-
 ?
6.1.1.19 2'-deoxyadenosine 5'-triphosphate + L-arginine + tRNAArg
-
 Saccharomyces pastorianus 2'-deoxyadenosine 5'-monophosphate + diphosphate + L-arginyl-tRNAArg
-
 ?
6.1.1.19 2'-O-methyladenosine 5'-triphosphate + L-arginine + tRNAArg
-
 Saccharomyces pastorianus 2'-O-methyladenosine 5'-monophosphate + diphosphate + L-arginyl-tRNAArg
-
 ?
6.1.1.19 3'-O-methyladenosine 5'-triphosphate + L-arginine + tRNAArg
-
 Saccharomyces pastorianus 3'-O-methyladenosine 5'-monophosphate + diphosphate + L-arginyl-tRNAArg
-
 ?
6.1.1.19 ATP + L-arginine + tRNAArg
-
 Saccharomyces pastorianus AMP + diphosphate + L-arginyl-tRNAArg
-
 ?
6.1.1.19 formycin 5'-triphosphate + L-arginine + tRNAArg
-
 Saccharomyces pastorianus formycin 5'-monophosphate + diphosphate + L-arginyl-tRNAArg
-
 ?
6.1.1.19 additional information positions 2, 6, 7, 8, and 9 of the purine moiety and 2' and 3' of the sugar moiety of the ATP molecule are important for catalytic action of the aminoacyl-tRNA synthetase Saccharomyces pastorianus ?
-
 ?
6.1.1.19 tubercidin 5'-triphosphate + L-arginine + tRNAArg
-
 Saccharomyces pastorianus tubercidin 5'-monophosphate + diphosphate + L-arginyl-tRNAArg
-
 ?