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Literature summary extracted from
- Corticosteroid side-chain isomerase in the circulatory system (1991), Steroids, 56, 12-16.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.3.1.21 | Co2+ | - |
Canis lupus familiaris |  |
| 5.3.1.21 | Co2+ | - |
Oryctolagus cuniculus | |
| 5.3.1.21 | Co2+ | - |
Ovis aries | |
| 5.3.1.21 | Ni2+ | - |
Canis lupus familiaris | |
| 5.3.1.21 | Ni2+ | - |
Oryctolagus cuniculus | |
| 5.3.1.21 | Ni2+ | - |
Ovis aries | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.3.1.21 | Co2+ | no effect | Sus scrofa | |
| 5.3.1.21 | Co2+ | no effect | Bos taurus | |
| 5.3.1.21 | Co2+ | no effect | Equus caballus | |
| 5.3.1.21 | Co2+ | stimulates | Gallus gallus | |
| 5.3.1.21 | Co2+ | stimulates | Cavia porcellus | |
| 5.3.1.21 | Co2+ | stimulates | Mus musculus | |
| 5.3.1.21 | Co2+ | stimulates | Rattus norvegicus | |
| 5.3.1.21 | Ni2+ | no effect | Sus scrofa | |
| 5.3.1.21 | Ni2+ | no effect | Bos taurus | |
| 5.3.1.21 | Ni2+ | no effect | Equus caballus | |
| 5.3.1.21 | Ni2+ | stimulates | Gallus gallus | |
| 5.3.1.21 | Ni2+ | stimulates | Cavia porcellus | |
| 5.3.1.21 | Ni2+ | stimulates | Mus musculus | |
| 5.3.1.21 | Ni2+ | stimulates | Rattus norvegicus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.3.1.21 | Bos taurus | - |
cow | - |
| 5.3.1.21 | Canis lupus familiaris | - |
- |
- |
| 5.3.1.21 | Cavia porcellus | - |
- |
- |
| 5.3.1.21 | Equus caballus | - |
- |
- |
| 5.3.1.21 | Gallus gallus | - |
- |
- |
| 5.3.1.21 | Homo sapiens | - |
- |
- |
| 5.3.1.21 | Mus musculus | - |
- |
- |
| 5.3.1.21 | Oryctolagus cuniculus | - |
- |
- |
| 5.3.1.21 | Ovis aries | - |
- |
- |
| 5.3.1.21 | Rattus norvegicus | - |
- |
- |
| 5.3.1.21 | Sus scrofa | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 5.3.1.21 | blood | - |
Gallus gallus | - |
| 5.3.1.21 | blood | - |
Cavia porcellus | - |
| 5.3.1.21 | blood | - |
Homo sapiens | - |
| 5.3.1.21 | blood | - |
Rattus norvegicus | - |
| 5.3.1.21 | blood | - |
Sus scrofa | - |
| 5.3.1.21 | blood | - |
Bos taurus | - |
| 5.3.1.21 | blood | - |
Ovis aries | - |
| 5.3.1.21 | blood | - |
Equus caballus | - |
| 5.3.1.21 | blood | erythrocytes show the highest activity, plasma low, and white blood cells low but highly variable levels of enzyme, circulating isomerase is derived in part from tissue sources and is in part an intrinsic blood enzyme | Mus musculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.3.1.21 | 11-Deoxycorticosterone | - |
Gallus gallus | 20-Hydroxy-3-oxopregn-4-en-21-al | - |
? | |
| 5.3.1.21 | 11-Deoxycorticosterone | - |
Cavia porcellus | 20-Hydroxy-3-oxopregn-4-en-21-al | - |
? | |
| 5.3.1.21 | 11-Deoxycorticosterone | - |
Mus musculus | 20-Hydroxy-3-oxopregn-4-en-21-al | - |
? | |
| 5.3.1.21 | 11-Deoxycorticosterone | - |
Homo sapiens | 20-Hydroxy-3-oxopregn-4-en-21-al | - |
? | |
| 5.3.1.21 | 11-Deoxycorticosterone | - |
Rattus norvegicus | 20-Hydroxy-3-oxopregn-4-en-21-al | - |
? | |
| 5.3.1.21 | 11-Deoxycorticosterone | - |
Sus scrofa | 20-Hydroxy-3-oxopregn-4-en-21-al | - |
? | |
| 5.3.1.21 | 11-Deoxycorticosterone | - |
Bos taurus | 20-Hydroxy-3-oxopregn-4-en-21-al | - |
? | |
| 5.3.1.21 | 11-Deoxycorticosterone | - |
Oryctolagus cuniculus | 20-Hydroxy-3-oxopregn-4-en-21-al | - |
? | |
| 5.3.1.21 | 11-Deoxycorticosterone | - |
Ovis aries | 20-Hydroxy-3-oxopregn-4-en-21-al | - |
? | |
| 5.3.1.21 | 11-Deoxycorticosterone | - |
Canis lupus familiaris | 20-Hydroxy-3-oxopregn-4-en-21-al | - |
? | |
| 5.3.1.21 | 11-Deoxycorticosterone | - |
Equus caballus | 20-Hydroxy-3-oxopregn-4-en-21-al | - |
? | |
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