EC Number | Cloned (Comment) | Organism |
---|---|---|
3.6.1.7 | muscle type and common type isoenzymes, expression in Escherichia coli | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.6.1.7 | R23Q | mutant of muscle type enzyme is totally inactive using benzoylphosphate as a substrate and not able to bind the phosphate moiety of that substrate | Homo sapiens |
3.6.1.7 | R23Q | mutant inactive on DNA, Arg23 possible has a central role for muscle type acylphosphatase activity on DNA | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.6.1.7 | EDTA | inhibition of ribonucleolytic and deoxyribonucleolytic activity of acylphosphatase | Bos taurus | |
3.6.1.7 | EDTA | 1 mM: 100% inhibition of endonucleolytic activity of both isoforms; inhibition of ribonucleolytic and deoxyribonucleolytic activity of acylphosphatase | Homo sapiens | |
3.6.1.7 | EDTA | inhibition of ribonucleolytic and deoxyribonucleolytic activity of acylphosphatase | Meleagris gallopavo | |
3.6.1.7 | phosphate | phosphate: inhibition of nucleolytic activity | Bos taurus | |
3.6.1.7 | phosphate | phosphate, 1 mM: competitive inhibition of DNAase activity of muscle and common type acylphosphatase, no inhibition of ribonucleolytic activity; phosphate: inhibition of nucleolytic activity | Homo sapiens | |
3.6.1.7 | phosphate | phosphate: inhibition of nucleolytic activity | Meleagris gallopavo |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.6.1.7 | cytoplasm | - |
Meleagris gallopavo | 5737 | - |
3.6.1.7 | cytoplasm | - |
Homo sapiens | 5737 | - |
3.6.1.7 | cytoplasm | - |
Bos taurus | 5737 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.6.1.7 | divalent cations | nucleolytic activity, depends on | Homo sapiens | |
3.6.1.7 | Mg2+ | Mg2+ dependent deoxyribonuclease and ribonuclease activity, required for nucleolytic activity | Meleagris gallopavo | |
3.6.1.7 | Mg2+ | Mg2+ dependent deoxyribonuclease and ribonuclease activity, required for nucleolytic activity | Homo sapiens | |
3.6.1.7 | Mg2+ | Mg2+ dependent deoxyribonuclease and ribonuclease activity, required for nucleolytic activity | Bos taurus | |
3.6.1.7 | MgCl2 | Mg2+ dependent deoxyribonuclease and ribonuclease activity, required for activity | Meleagris gallopavo | |
3.6.1.7 | MgCl2 | Mg2+ dependent deoxyribonuclease and ribonuclease activity, required for activity | Homo sapiens | |
3.6.1.7 | MgCl2 | Mg2+ dependent deoxyribonuclease and ribonuclease activity, required for activity | Bos taurus | |
3.6.1.7 | Mn2+ | DNAase activity, able to completely substitute Mg2+, required for nucleolytic activity | Homo sapiens | |
3.6.1.7 | additional information | Ca2+ has no activating effect on the nucleolytic activity of acylphosphatase | Homo sapiens | |
3.6.1.7 | Zn2+ | DNAase activity, activation of nucleolytic activity, less effective compared with Mg2+ | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.6.1.7 | additional information | Meleagris gallopavo | nucleolytic activity of muscle and common type isoform acylphosphatase on RNA and DNA is possible physiological activity of these isoenzymes in the cell | ? | - |
? | |
3.6.1.7 | additional information | Homo sapiens | nucleolytic activity of muscle and common type isoform acylphosphatase on RNA and DNA is possible physiological activity of these isoenzymes in the cell | ? | - |
? | |
3.6.1.7 | additional information | Bos taurus | nucleolytic activity of muscle and common type isoform acylphosphatase on RNA and DNA is possible physiological activity of these isoenzymes in the cell | ? | - |
? | |
3.6.1.7 | additional information | Meleagris gallopavo | acylphosphatase is active as a nuclease at pH ranging from 5.5 to 6.8 suggests that enzymes could play some role in apoptotic mechanisms | ? | - |
? | |
3.6.1.7 | additional information | Homo sapiens | acylphosphatase is active as a nuclease at pH ranging from 5.5 to 6.8 suggests that enzymes could play some role in apoptotic mechanisms | ? | - |
? | |
3.6.1.7 | additional information | Bos taurus | acylphosphatase is active as a nuclease at pH ranging from 5.5 to 6.8 suggests that enzymes could play some role in apoptotic mechanisms | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.6.1.7 | Bos taurus | - |
bovine | - |
3.6.1.7 | Bos taurus | - |
common type, CT, isoenzyme | - |
3.6.1.7 | Homo sapiens | - |
human | - |
3.6.1.7 | Homo sapiens | - |
recombinant and mutants, R23Q mutant | - |
3.6.1.7 | Meleagris gallopavo | - |
turkey | - |
3.6.1.7 | Meleagris gallopavo | - |
muscle type, MT, isoenzyme | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.6.1.7 | recombinant muscle type and common type isoenzymes | Homo sapiens |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
3.6.1.7 | an acylphosphate + H2O = a carboxylate + phosphate | reaction mechanism | Homo sapiens | |
3.6.1.7 | an acylphosphate + H2O = a carboxylate + phosphate | reaction mechanism | Bos taurus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.6.1.7 | testis | - |
Homo sapiens | - |
3.6.1.7 | testis | common type enzyme | Bos taurus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.6.1.7 | 1,3-diphosphoglycerate + H2O | - |
Meleagris gallopavo | 3-phosphoglycerate + phosphate | - |
? | |
3.6.1.7 | 1,3-diphosphoglycerate + H2O | - |
Homo sapiens | 3-phosphoglycerate + phosphate | - |
? | |
3.6.1.7 | 1,3-diphosphoglycerate + H2O | - |
Bos taurus | 3-phosphoglycerate + phosphate | - |
? | |
3.6.1.7 | acylphosphate + H2O | specifically catalyzes the hydrolysis of the carboxyl-phosphate bond of various acylphosphates | Meleagris gallopavo | carboxylate + phosphate | - |
? | |
3.6.1.7 | acylphosphate + H2O | specifically catalyzes the hydrolysis of the carboxyl-phosphate bond of various acylphosphates | Homo sapiens | carboxylate + phosphate | - |
? | |
3.6.1.7 | acylphosphate + H2O | specifically catalyzes the hydrolysis of the carboxyl-phosphate bond of various acylphosphates | Bos taurus | carboxylate + phosphate | - |
? | |
3.6.1.7 | benzoyl phosphate + H2O | - |
Meleagris gallopavo | benzoate + phosphate | - |
? | |
3.6.1.7 | benzoyl phosphate + H2O | - |
Homo sapiens | benzoate + phosphate | - |
? | |
3.6.1.7 | benzoyl phosphate + H2O | - |
Bos taurus | benzoate + phosphate | - |
? | |
3.6.1.7 | carbamoyl phosphate + H2O | - |
Meleagris gallopavo | carbamate + phosphate | - |
? | |
3.6.1.7 | carbamoyl phosphate + H2O | - |
Homo sapiens | carbamate + phosphate | - |
? | |
3.6.1.7 | carbamoyl phosphate + H2O | - |
Bos taurus | carbamate + phosphate | - |
? | |
3.6.1.7 | DNA + H2O | muscle type and common type hydrolyze double stranded DNA, high molecular weight human genomic DNA | Homo sapiens | ? | - |
? | |
3.6.1.7 | DNA + H2O | DNAase activity, nucleolytic activity, exonucleolytic and endonucleolytic activity, in both muscle type, MT, and erythrocyte or common type, CT, isoenzymes | Meleagris gallopavo | ? | - |
? | |
3.6.1.7 | DNA + H2O | DNAase activity, nucleolytic activity, exonucleolytic and endonucleolytic activity, in both muscle type, MT, and erythrocyte or common type, CT, isoenzymes | Homo sapiens | ? | - |
? | |
3.6.1.7 | DNA + H2O | DNAase activity, nucleolytic activity, exonucleolytic and endonucleolytic activity, in both muscle type, MT, and erythrocyte or common type, CT, isoenzymes | Bos taurus | ? | - |
? | |
3.6.1.7 | DNA + H2O | endonucleolytic activity on plasmid DNA, pRcCMV plasmid DNA, closed circular plasmid DNA, exonucleolytic activity on linear plasmid DNA | Homo sapiens | ? | - |
? | |
3.6.1.7 | additional information | specifically catalyzes the hydrolysis of the carboxyl-phosphate bond of various acylphosphates | Meleagris gallopavo | ? | - |
? | |
3.6.1.7 | additional information | specifically catalyzes the hydrolysis of the carboxyl-phosphate bond of various acylphosphates | Homo sapiens | ? | - |
? | |
3.6.1.7 | additional information | specifically catalyzes the hydrolysis of the carboxyl-phosphate bond of various acylphosphates | Bos taurus | ? | - |
? | |
3.6.1.7 | additional information | nucleolytic, ribonucleolytic and deoxyribonucleolytic, activity, exonucleolytic and endonucleolytic activity, in both muscle type, MT, and erythrocyte or common type, CT, isoenzymes | Meleagris gallopavo | ? | - |
? | |
3.6.1.7 | additional information | nucleolytic, ribonucleolytic and deoxyribonucleolytic, activity, exonucleolytic and endonucleolytic activity, in both muscle type, MT, and erythrocyte or common type, CT, isoenzymes | Homo sapiens | ? | - |
? | |
3.6.1.7 | additional information | nucleolytic, ribonucleolytic and deoxyribonucleolytic, activity, exonucleolytic and endonucleolytic activity, in both muscle type, MT, and erythrocyte or common type, CT, isoenzymes | Bos taurus | ? | - |
? | |
3.6.1.7 | additional information | nucleolytic activity of muscle and common type isoform acylphosphatase on RNA and DNA is possible physiological activity of these isoenzymes in the cell | Meleagris gallopavo | ? | - |
? | |
3.6.1.7 | additional information | nucleolytic activity of muscle and common type isoform acylphosphatase on RNA and DNA is possible physiological activity of these isoenzymes in the cell | Homo sapiens | ? | - |
? | |
3.6.1.7 | additional information | nucleolytic activity of muscle and common type isoform acylphosphatase on RNA and DNA is possible physiological activity of these isoenzymes in the cell | Bos taurus | ? | - |
? | |
3.6.1.7 | additional information | acylphosphatase is active as a nuclease at pH ranging from 5.5 to 6.8 suggests that enzymes could play some role in apoptotic mechanisms | Meleagris gallopavo | ? | - |
? | |
3.6.1.7 | additional information | acylphosphatase is active as a nuclease at pH ranging from 5.5 to 6.8 suggests that enzymes could play some role in apoptotic mechanisms | Homo sapiens | ? | - |
? | |
3.6.1.7 | additional information | acylphosphatase is active as a nuclease at pH ranging from 5.5 to 6.8 suggests that enzymes could play some role in apoptotic mechanisms | Bos taurus | ? | - |
? | |
3.6.1.7 | nucleic acids + H2O | nucleolytic activity, in both muscle type, MT, and erythrocyte or common type, CT, isoenzymes | Meleagris gallopavo | ? | - |
? | |
3.6.1.7 | nucleic acids + H2O | nucleolytic activity, in both muscle type, MT, and erythrocyte or common type, CT, isoenzymes | Homo sapiens | ? | - |
? | |
3.6.1.7 | nucleic acids + H2O | nucleolytic activity, in both muscle type, MT, and erythrocyte or common type, CT, isoenzymes | Bos taurus | ? | - |
? | |
3.6.1.7 | poly (rA) + H2O | ribonucleolytic activity, in both muscle type, MT, and erythrocyte or common type, CT, isoenzymes | Meleagris gallopavo | ? | - |
? | |
3.6.1.7 | poly (rA) + H2O | ribonucleolytic activity, in both muscle type, MT, and erythrocyte or common type, CT, isoenzymes | Homo sapiens | ? | - |
? | |
3.6.1.7 | poly (rA) + H2O | ribonucleolytic activity, in both muscle type, MT, and erythrocyte or common type, CT, isoenzymes | Bos taurus | ? | - |
? | |
3.6.1.7 | RNA + H2O | RNAase activity, ribonucleolytic activity, in both muscle type, MT, and erythrocyte or common type, CT, isoenzymes | Meleagris gallopavo | ? | - |
? | |
3.6.1.7 | RNA + H2O | RNAase activity, ribonucleolytic activity, in both muscle type, MT, and erythrocyte or common type, CT, isoenzymes | Homo sapiens | ? | - |
? | |
3.6.1.7 | RNA + H2O | RNAase activity, ribonucleolytic activity, in both muscle type, MT, and erythrocyte or common type, CT, isoenzymes | Bos taurus | ? | - |
? | |
3.6.1.7 | RNA + H2O | Mg2+ dependent activity | Meleagris gallopavo | ? | - |
? | |
3.6.1.7 | RNA + H2O | Mg2+ dependent activity | Homo sapiens | ? | - |
? | |
3.6.1.7 | RNA + H2O | Mg2+ dependent activity | Bos taurus | ? | - |
? | |
3.6.1.7 | succinoyl phosphate + H2O | - |
Meleagris gallopavo | succinate + phosphate | - |
? | |
3.6.1.7 | succinoyl phosphate + H2O | - |
Homo sapiens | succinate + phosphate | - |
? | |
3.6.1.7 | succinoyl phosphate + H2O | - |
Bos taurus | succinate + phosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.6.1.7 | More | two isoenzymatic forms: one prevalent in skeletal and cardiac muscle named muscle type, the other in red blood cells named erythrocyte or common type, even if both isoforms are expressed in all tissues | Meleagris gallopavo |
3.6.1.7 | More | two isoenzymatic forms: one prevalent in skeletal and cardiac muscle named muscle type, the other in red blood cells named erythrocyte or common type, even if both isoforms are expressed in all tissues | Homo sapiens |
3.6.1.7 | More | two isoenzymatic forms: one prevalent in skeletal and cardiac muscle named muscle type, the other in red blood cells named erythrocyte or common type, even if both isoforms are expressed in all tissues | Bos taurus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.6.1.7 | 37 | - |
nucleolytic activity, assay at | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.6.1.7 | 5.5 | - |
nucleolytic activity, assay at | Homo sapiens |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
3.6.1.7 | 4.5 | 6.5 | Mg2+ dependent ribonucleolytic activity | Homo sapiens |
3.6.1.7 | 5 | 6.8 | Mg2+ dependent deoxyribonuclease and ribonuclease activity | Meleagris gallopavo |
3.6.1.7 | 5 | 6.8 | Mg2+ dependent deoxyribonuclease and ribonuclease activity | Homo sapiens |
3.6.1.7 | 5 | 6.8 | Mg2+ dependent deoxyribonuclease and ribonuclease activity | Bos taurus |
3.6.1.7 | 7 | - |
Mg2+ dependent ribonucleolytic and deoxyribonucleolytic activity: no activity above pH 7.0 | Homo sapiens |